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Polynucleotide Immunization for Cancer Therapy

  • Chapter
Book cover Cancer Gene Therapy

Part of the book series: Contemporary Cancer Research ((CCR))

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Abstract

The limitations of conventional cancer therapy (surgery, radiation, and chemotherapy) combined with a better understanding of the molecular mechanisms regulating the immune system have led to increasing attention focused on the development of immunotherapies for cancer. Active immunotherapy approaches seek to eliminate tumor cells by eliciting immune responses directed against tumor-associated antigens. Gene transfer techniques have expanded the potential opportunities in this area by providing new methods for stimulating the immune response. Among the array of techniques under development for clinical application, nucleic acid or polynucleotide vaccines have emerged as a novel and effective method of inducing tumor antigen-specific immune responses.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    Theresa V. Strong

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  1. Theresa V. Strong
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Editors and Affiliations

  1. Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

  2. Division of Human Gene Therapy, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

  3. Division of Human Gene Therapy, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

  4. Division of Human Gene Therapy, Department of Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

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© 2005 Humana Press Inc., Totowa, NJ

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Strong, T.V. (2005). Polynucleotide Immunization for Cancer Therapy. In: Curiel, D.T., Douglas, J.T. (eds) Cancer Gene Therapy. Contemporary Cancer Research. Humana Press. https://doi.org/10.1007/978-1-59259-785-7_12

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