Chapter

Metabolic Syndrome and Diabetes

pp 111-123

Obesity and Cancer

  • Robert W. O’RourkeAffiliated withDepartment of Surgery, University of Michigan Email author 

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Abstract

Obesity is a strong risk factor for multiple types of cancer. The mechanisms underlying this association are multiple and include increased systemic inflammation, increased alterations in the systemic hormonal milieu, and direct paracrine tumor-promoting effects of adipose tissue, adipose tissue stem cells, and mature adipocytes. These complex mechanisms generate a carcinogenic milieu in multiple tissues in obesity.

Keywords

Obesity Risk factor Cancer Systemic inflammation Systemic hormonal milieu Adipose tissue Adipocytes