Abstract
Traumatic brain injury (TBI) is a dynamic process, and pathology evolves over time. Despite its frequent occurrence with significant personal and socioeconomic impact, our understanding of TBI is still limited. In the acute phase of TBI, CT scanning is of great value because it permits fast detection of lesions that may require urgent surgical treatment. However, it only captures limited information on the full extent of structural damage and does not provide any insight into function.
Specific MRI sequences, i.e., susceptibility weighted imaging (SWI) and diffusion weighted imaging (DWI), are more sensitive for detecting structural changes in the brain, particularly smaller lesions, such as microhemorrhages, and traumatic or diffuse axonal injury (TAI/DAI). Diffusion tensor imaging (DTI) can provide valuable additional information about both white matter lesions and structural damage, which can be used for better characterization and to establish more accurate prognosis.
This chapter will elaborate on the role of diffusion tensor imaging in traumatic brain injury for research and clinical practice.
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References
Menon DK, Schwab K, Maas AIR. Demographics and Clinical Assessment Working Group of the international and interagency initiative toward common data elements for Research on Traumatic Brain Injury and Psychological Health; Position statement: definition of traumatic brain injury. Arch Phys Med Rehabil. 2010;91(11):1637–40.
Finkelstein EA, Corso PS, Miller TR. The incidence and economic burden of injuries in the United States. New York, NY, USA: Oxford University Press; 2006. Xiii. p. 187.
Marshall LF, Bowers Marshall S, Klauber MR, Van Berkum Clark M, Eisenberg HM, Jane JA, Luerssen TG, Marmarou A, Foulkes MA. A new classification of head injury based on computerised tomography. Spec Suppl. 1991;75(1s):S14–20.
Saatman KE, Duhaime A-C, Bullock R, Maas AIR, Valadka A, Manley GT. Workshop scientific team and advisory panel members. Classification of traumatic brain injury for targeted therapies. J Neurotrauma. 2008;25:719–39.
Maas AIR, Hukkelhoven CWPM, Marshall LF, Steyerberg EW. Prediction of outcome in traumatic brain injury with computed tomographic characteristics: a comparison between the computed tomographic classification and combinations of computed tomographic predictors. Neurosurgery. 2005;57:1173–82.
Sener S, Rozenbeek B, Maas AIR. Surgical management of traumatic brain injury—evidences, controversies and perspectives for the futures. Eur Neurol Rev. 2011;6(3):196–201.
Shenton ME, Hamoda HM, Schneiderman JS, Bouix S, Pasternak O, Rathi Y, Vu M-A, Purohit MP, Helmer K, Koerte I, Lin AP, Kikinis R, Kubicki M, Stern RA, Zafonte R. A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging Behav. 2012;6:137–92.
Lee B, Newberg A. Neuroimaging in traumatic brain imaging. NeuroRx. 2005;2:372–83.
Mittle RL, Grossman RI, Hiehle JF, Hurst RW, Kauder DR, Gennarelli RA, et al. Prevalence of MR evidence of diffuse axonal injury in patients with mild head injury and normal head CT findings. Am J Neuroradiol. 1994;15:1583–9.
Hammoud DA, Wasserman BA. Diffuse axonal injuries: pathophysiology and imaging. Neuroimaging Clin N Am. 2002;12(2):205–16.
Ezaki Y, Tsutsumi K, Morikawa M, Nagata I. Role of diffusion-weighted magnetic resonance imaging in diffuse axonal injury. Acta Radiol. 2006;47:733–40.
Kelly AB, Zimmerman RD, Snow RB, Gandy SE, Heier LA, Deck MDF. Head trauma: comparison of MR and CT—experience in 100 patients. AJNR Am J Neuroradiol. 1988;9(4):699–708.
Murray JG, Gean AD, Evans SJ. Imaging of acute head injury. Semin Ultrasound CT MR. 1996;17:185–205.
Shaefer PW, Huisman TAGM, Sorensen AG, Gonzalez RG, Schwamm LH. Diffusion weighted MR Imaging in closed head injury: high correlation with initial Glasgow Coma Scale score and score on Modified Rankin scale at discharge. Radiology. 2004;233(1):58–66.
Smith DH, Meaney DF, Shull WH. Diffuse axonal injury in head trauma. J Head Trauma Rehabil. 2003;18:307–16.
Scheid R, Walther K, Guthke T, Preul C, von Cramon Y. Cognitive sequelae of diffuse axonal injury. Arch Neurol. 2006;63:418–24.
Skandsen T, Kvistad KA, Solheim O, Haavde Strand I, Folvik M, Vik A. Prevalence and impact of diffuse axonal injury in patients with moderate and severe head injury: a cohort study of early magnetic resonance imaging findings and 1-year outcome. J Neurosurg. 2010;113:556–63.
Chelly H, Chaari A, Daoud E, Dammak H, Medhioub F, Mnif J, Ben Hamida C, Bahloul M, Bouaziz M. Diffuse axonal injury in patients with head injuries: an epidemiologic and prognosis study of 124 cases. J Trauma. 2011;71:838–46.
Lipton ML, Gulko E, Zimmerman ME, Friedman BW, Kim M, Gellella E, Gold T, Shifteh K, Ardekani BA, Branch CA. Diffusion-tensor imaging implicates prefrontal axonal injury in executive function impairment following very mild traumatic brain injury. Radiology. 2009;252(3):816–24.
Dinkel J, Drier A, Khalilzadeh O, Perlbarg V, Czernecki V, Gupta R, Gomas F, Sanchze P, Dormont D, Galanaud D, Stevens RD, Puybasset L. for NICER (Neuro Imaging for Coma Emergence and Recovery) Consortium. Long-term white matter changes after severe traumatic brain injury: a 5-year prospective cohort. Am J Neuroradiol. 2014;35:23–9.
Newcombe VF, Williams GB, Nortje J, et al. Analysis of acute traumatic axonal injury using diffusion tensor imaging. Br J Neurosurg. 2007;21(4):340–8.
Aoki Y, Inokuchi R, Gunshin M, Yahagi N, Suwa H. Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis. J Neurol Neurosurg Psychiatry. 2012;83:870–6.
Rutgers DR, Toulgoat F, Cazejust J, Fillard P, Lasjaunias P, Ducreaux D. White matter abnormalities in mild traumatic brain injury: a diffusion tensor imaging study. Am J Neuroradiol. 2008;29:514–9.
Kraus MF, Susmaras T, Caughlin BP, Walker CJ, Weeney JA, Little DM. White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain. 2007;130:2508–19.
Van der Eerden AW, Khalilzadeh O, Perlbarg V, Dinkel J, Sanchez P, Vos PE, Luyt C-E, Stevens RD, Menjot de Champfleur N, Delmaire C, Tollard E, Gupta R, Dormont D, Laureys S, Benali H, Vanhaudenhuyse A, Galanaud D, Puybasset L. For NICER (Neuro Imaging for Coma Emergence and Recovery) Consortium. White matter changes in comatose survivors of anoxic ischemic encephalopathy and traumatic brain injury: comparative diffusion-tensor imaging study. Radiology. 2014;270:506–16.
Kasahara K, Hashimoto K, Abo M, Senoo A. Voxel- and atlas-based analysis of diffusion tensor imaging may reveal focal axonal injuries in mild traumatic brain injury—comparison with diffuse axonal injury. Magn Reson Imaging. 2012;30:496–505.
Perlbarg V, Puybasset L, Tollard E, Lehéricy S, Benali H, Galanaud D. Relation between brain lesion location and clinical outcome in patients with severe traumatic brain injury: a diffusion tensor imaging study using voxel-based approaches. Hum Brain Mapp. 2009;30:3924–33.
Tollard E, Galanaud D, Perlbarg V, Sancez-Pena P, Le Fur Y, Abdennour L, Cozzone P, Lehericy S, Chiras J, Puybasset L. Experience of diffusion tensor imaging and 1H spectroscopy for outcome prediction in severe traumatic brain injury: preliminary results. Crit Care Med. 2009;37:1448–55.
Parmentier-Decrucq E, Poissy J, Favory R, Nseir S, Onimus T, Guerry M-J, Durocher A, Mathieu D. Adverse events during intrahospital transport of critically ill patients: incidence and risk factors. Ann Intensive Care. 2013;3:10.
Le Bihan D, Poupon C, Amadon A, Lethimonnier F. Artefacts and pitfalls in diffusion MRI. J Magn Reson Imaging. 2006;24:478–88.
Suggested Reading
Yeh P-H, Oakes TR, Riedy G. Diffusion tensor imaging and its application to traumatic brain injury: basic principles and recent advances. Open J Med Imaging. 2012;2:137–61.
Hulkower MB, Poliak DB, Rosenbaum SB, Zimmerman ME, Lipton ML. A decade of DTI in traumatic brain injury: 10 years and 100 articles later. AJNR Am J Neuroradiol. 2013;34(11):2064–74.
Xiong K, Zhu Y, Zhang W. Diffusion tensor imaging and magnetic resonance spectroscopy in traumatic brain injury: a review of recent literature. Brain Imaging Behav. 2014;8(4):487–96. doi:10.1007/s11682-013-9288-2 [Epub ahead of print].
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Sener, S., Parizel, P.M., Maas, A.I.R. (2016). Diffusion Tensor Imaging in Traumatic Brain Injury. In: Van Hecke, W., Emsell, L., Sunaert, S. (eds) Diffusion Tensor Imaging. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3118-7_19
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