Abstract
Peptic ulcers, mucosal erosions, erosive esophagitis, Mallory-Weiss tear, angiodysplasias, gastric antral vascular ectasia, and tumors are common causes of non-variceal upper gastrointestinal bleeding (NVUGIB). Endoscopy is an integral part of the management algorithm for NVUGIB. Endoscopic modalities that have proven to be effective in achieving primary hemostasis and preventing rebleeding include injection therapy, thermal therapies, and mechanical devices, such as clips and bands. The identification of bleeding lesions that are suitable for endoscopic hemostasis, careful selection of specific device(s) for a particular lesion, and operator familiarity and dexterity in handling hemostatic devices are principal determinants for a successful endoscopic outcome.
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References
Hwang JH et al. The role of endoscopy in the management of acute non-variceal upper GI bleeding. Gastrointest Endosc. 2012;75(6):1132–8.
Rockall TA et al. Incidence of and mortality from acute upper gastrointestinal haemorrhage in the United Kingdom. Steering committee and members of the national audit of acute upper gastrointestinal haemorrhage. BMJ. 1995;311(6999):222–6.
Boonpongmanee S et al. The frequency of peptic ulcer as a cause of upper-GI bleeding is exaggerated. Gastrointest Endosc. 2004;59(7):788–94.
Chak A et al. Effectiveness of endoscopy in patients admitted to the intensive care unit with upper GI hemorrhage. Gastrointest Endosc. 2001;53(1):6–13.
Lin HJ et al. Early or delayed endoscopy for patients with peptic ulcer bleeding. A prospective randomized study. J Clin Gastroenterol. 1996;22(4):267–71.
Laine L, Jensen DM. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012;107(3):345–60. quiz 361.c.
Barkun AN et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010;152(2):101–13.
Laine L, McQuaid KR. Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials. Clin Gastroenterol Hepatol. 2009;7(1):33–47. quiz 1–2.
Gralnek IM, Barkun AN, Bardou M. Management of acute bleeding from a peptic ulcer. N Engl J Med. 2008;359(9):928–37.
Fordtman SA, editor. Sleisenger and Fordtran’s gastrointestinal and liver disease, vol. 1. 9th ed. Philadelphia: Saunders/Elsevier; 2010.
Masaoka T et al. Blatchford scoring system is a useful scoring system for detecting patients with upper gastrointestinal bleeding who do not need endoscopic intervention. J Gastroenterol Hepatol. 2007;22(9):1404–8.
Robins GG et al. Evaluation of the need for endoscopy to identify low-risk patients presenting with an acute upper gastrointestinal bleed suitable for early discharge. Postgrad Med J. 2007;83(986):768–72.
Stanley AJ et al. Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation. Lancet. 2009;373(9657):42–7.
Spiegel BM, Vakil NB, Ofman JJ. Endoscopy for acute nonvariceal upper gastrointestinal tract hemorrhage: is sooner better? A systematic review. Arch Intern Med. 2001;161(11):1393–404.
Tsoi KK, Ma TK, Sung JJ. Endoscopy for upper gastrointestinal bleeding: how urgent is it? Nat Rev Gastroenterol Hepatol. 2009;6(8):463–9.
Yen D et al. Arterial oxygen desaturation during emergent nonsedated upper gastrointestinal endoscopy in the emergency department. Am J Emerg Med. 1997;15(7):644–7.
Hearnshaw SA et al. Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut. 2011;60(10):1327–35.
Conway JD et al. Endoscopic hemostatic devices. Gastrointest Endosc. 2009;69(6):987–96.
Lin HJ et al. A prospective, randomized trial of large- versus small-volume endoscopic injection of epinephrine for peptic ulcer bleeding. Gastrointest Endosc. 2002;55(6):615–9.
Laine L. Therapeutic endoscopy and bleeding ulcers. Bipolar/multipolar electrocoagulation. Gastrointest Endosc. 1990;36(5 Suppl):S38–41.
Fullarton GM et al. Controlled trial of heater probe treatment in bleeding peptic ulcers. Br J Surg. 1989;76(6):541–4.
Ginsberg GG et al. The argon plasma coagulator: February 2002. Gastrointest Endosc. 2002;55(7):807–10.
Watson JP et al. The tissue effect of argon plasma coagulation on esophageal and gastric mucosa. Gastrointest Endosc. 2000;52(3):342–5.
Cipolletta L et al. Prospective comparison of argon plasma coagulator and heater probe in the endoscopic treatment of major peptic ulcer bleeding. Gastrointest Endosc. 1998;48(2):191–5.
Raju GS, Gajula L. Endoclips for GI endoscopy. Gastrointest Endosc. 2004;59(2):267–79.
Chuttani R et al. Endoscopic clip application devices. Gastrointest Endosc. 2006;63(6):746–50.
Banerjee S et al. Endoscopic closure devices. Gastrointest Endosc. 2012;76(2):244–51.
Kirschniak A et al. A new endoscopic over-the-scope clip system for treatment of lesions and bleeding in the GI tract: first clinical experiences. Gastrointest Endosc. 2007;66(1):162–7.
Monkemuller K et al. Utility of the “bear claw”, or over-the-scope clip (OTSC) system, to provide endoscopic hemostasis for bleeding posterior duodenal ulcers. Endoscopy. 2012;44(Suppl 2 UCTN):E412–3.
Alis H et al. Is endoscopic band ligation superior to injection therapy for Dieulafoy lesion? Surg Endosc. 2009;23(7):1465–9.
Gralnek IM et al. Capsule endoscopy in acute upper gastrointestinal hemorrhage: a prospective cohort study. Endoscopy. 2013;45(1):12–9.
Sung JJ et al. Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding. Endoscopy. 2011;43(4):291–5.
Giday SA et al. Long-term randomized controlled trial of a novel nanopowder hemostatic agent (TC-325) for control of severe arterial upper gastrointestinal bleeding in a porcine model. Endoscopy. 2011;43(4):296–9.
Alpay A et al. Use of a novel haemostatic agent: ankaferd blood stopper in conjunctival incisions. Clin Exp Ophthalmol. 2011;39(8):793–8.
Barkun AN, Moosavi S, Martel M. Topical hemostatic agents: a systematic review with particular emphasis on endoscopic application in GI bleeding. Gastrointest Endosc. 2013;77(5):692–700.
Baykul T, Alanoglu EG, Kocer G. Use of Ankaferd blood stopper as a hemostatic agent: a clinical experience. J Contemp Dent Pract. 2010;11(1):E088–94.
Huri E et al. First clinical experience of Ankaferd BloodStopper as a hemostatic agent in partial nephrectomy. Kaohsiung J Med Sci. 2010;26(9):493–5.
Leblebisatan G et al. Topical Ankaferd hemostat application for the management of oral cavity bleedings in children with hemorrhagic diathesis. Blood Coagul Fibrinolysis. 2012;23(6):494–7.
Teker AM et al. Prospective, controlled clinical trial of Ankaferd Blood Stopper in children undergoing tonsillectomy. Int J Pediatr Otorhinolaryngol. 2009;73(12):1742–5.
Laine L, Peterson WL. Bleeding peptic ulcer. N Engl J Med. 1994;331(11):717–27.
Enestvedt BK et al. An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium. Gastrointest Endosc. 2008;67(3):422–9.
Sung JJ et al. Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding: a randomized trial. Ann Intern Med. 2009;150(7):455–64.
Chung SC et al. Endoscopic injection of adrenaline for actively bleeding ulcers: a randomised trial. Br Med J (Clin Res Ed). 1988;296(6637):1631–3.
Bharucha AE, Gostout CJ, Balm RK. Clinical and endoscopic risk factors in the Mallory-Weiss syndrome. Am J Gastroenterol. 1997;92(5):805–8.
Gunay K et al. Endoscopic ligation for patients with active bleeding Mallory-Weiss tears. Surg Endosc. 2001;15(11):1305–7.
Huang SP et al. Endoscopic hemoclip placement and epinephrine injection for Mallory-Weiss syndrome with active bleeding. Gastrointest Endosc. 2002;55(7):842–6.
Morales P, Baum AE. Therapeutic alternatives for the Mallory-Weiss Tear. Curr Treat Options Gastroenterol. 2003;6(1):75–83.
Myung SJ, Kim HR, Moon YS. Severe Mallory-Weiss tear after endoscopy treated by endoscopic band ligation. Gastrointest Endosc. 2000;52(1):99–101.
Yamaguchi Y et al. Endoscopic hemoclipping for upper GI bleeding due to Mallory-Weiss syndrome. Gastrointest Endosc. 2001;53(4):427–30.
Gadenstatter M et al. Dieulafoy’s disease of the large and small bowel. J Clin Gastroenterol. 1998;27(2):169–72.
Norton ID et al. Management and long-term prognosis of Dieulafoy lesion. Gastrointest Endosc. 1999;50(6):762–7.
Wong RM et al. Endoscopic ligation for non-esophageal variceal upper gastrointestinal hemorrhage. Endoscopy. 1998;30(9):774–7.
Sebastian S, O'Morain CA, Buckley MJ. Review article: current therapeutic options for gastric antral vascular ectasia. Aliment Pharmacol Ther. 2003;18(2):157–65.
Pavey DA, Craig PI. Endoscopic therapy for upper-GI vascular ectasias. Gastrointest Endosc. 2004;59(2):233–8.
Savides TJ et al. Severe upper gastrointestinal tumor bleeding: endoscopic findings, treatment, and outcome. Endoscopy. 1996;28(2):244–8.
Loftus EV et al. Endoscopic treatment of major bleeding from advanced gastroduodenal malignant lesions. Mayo Clin Proc. 1994;69(8):736–40.
Mathus-Vliegen EM, Tytgat GN. Analysis of failures and complications of neodymium: YAG laser photocoagulation in gastrointestinal tract tumors. A retrospective survey of 18 years’ experience. Endoscopy. 1990;22(1):17–23.
Suzuki H et al. Endoscopic laser therapy in the curative and palliative treatment of upper gastrointestinal cancer. World J Surg. 1989;13(2):158–64.
Chen YI et al. Use of the endoscopically applied hemostatic powder TC-325 in cancer-related upper GI hemorrhage: preliminary experience (with video). Gastrointest Endosc. 2012;75(6):1278–81.
Lin HJ et al. Natural history of bleeding peptic ulcers with a tightly adherent blood clot: a prospective observation. Gastrointest Endosc. 1996;43(5):470–3.
Laine L, Stein C, Sharma V. A prospective outcome study of patients with clot in an ulcer and the effect of irrigation. Gastrointest Endosc. 1996;43(2 Pt 1):107–10.
Sung JJ et al. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison. Ann Intern Med. 2003;139(4):237–43.
Lau JY et al. The evolution of stigmata of hemorrhage in bleeding peptic ulcers: a sequential endoscopic study. Endoscopy. 1998;30(6):513–8.
Bleau BL et al. Recurrent bleeding from peptic ulcer associated with adherent clot: a randomized study comparing endoscopic treatment with medical therapy. Gastrointest Endosc. 2002;56(1):1–6.
Jensen DM et al. Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots. Gastroenterology. 2002;123(2):407–13.
Kahi CJ et al. Endoscopic therapy versus medical therapy for bleeding peptic ulcer with adherent clot: a meta-analysis. Gastroenterology. 2005;129(3):855–62.
Hay JA et al. Prospective evaluation of a clinical guideline recommending hospital length of stay in upper gastrointestinal tract hemorrhage. JAMA. 1997;278(24):2151–6.
Lai KC et al. A retrospective and prospective study on the safety of discharging selected patients with duodenal ulcer bleeding on the same day as endoscopy. Gastrointest Endosc. 1997;45(1):26–30.
Moreno P et al. Efficacy and safety of an early discharge protocol in low-risk patients with upper gastrointestinal bleeding. Am J Med. 1998;105(3):176–81.
Lee JG et al. Endoscopy-based triage significantly reduces hospitalization rates and costs of treating upper GI bleeding: a randomized controlled trial. Gastrointest Endosc. 1999;50(6):755–61.
Cipolletta L et al. Outpatient management for low-risk nonvariceal upper GI bleeding: a randomized controlled trial. Gastrointest Endosc. 2002;55(1):1–5.
Marmo R et al. Outcome of endoscopic treatment for peptic ulcer bleeding: Is a second look necessary? A meta-analysis. Gastrointest Endosc. 2003;57(1):62–7.
Tsoi KK et al. Second-look endoscopy with thermal coagulation or injections for peptic ulcer bleeding: a meta-analysis. J Gastroenterol Hepatol. 2010;25(1):8–13.
Chiu PW et al. Effect of scheduled second therapeutic endoscopy on peptic ulcer rebleeding: a prospective randomised trial. Gut. 2003;52(10):1403–7.
El Quali S et al. Is routine second-look endoscopy effective after endoscopic hemostasis in acute peptic ulcer bleeding? A meta-analysis. Gastrointest Endosc. 2012;76(2):283–92.
Spiegel BM et al. Minimizing recurrent peptic ulcer hemorrhage after endoscopic hemostasis: the cost-effectiveness of competing strategies. Am J Gastroenterol. 2003;98(1):86–97.
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Electronic Supplementary Material
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Actively bleeding gastric ulcer treated with epinephrine injection and heater probe coagulation (MP4 47696 kb)
Gastric antral vascular ectasia treated with argon plasma coagulation (MP4 22551 kb)
Actively oozing gastric ulcer treated with clip placement (MP4 14076 kb)
Salvage over-the-scope clip placement for recurrent post-polypectomy duodenal bleeding (MP4 14046 kb)
Gastric Dieulafoy lesion treated with endoscopic band ligation (MP4 20681 kb)
Persistent peptic ulcer bleeding treated with a hemostatic spray (MP4 16773 kb)
Ulcer and bleeding stigmata unsuitable for endoscopic therapy (MP4 14764 kb)
Mallory-Weiss tear treated with clip placement (MP4 24503 kb)
Endoscopic management of a peptic ulcer with an adherent clot (MP4 22987 kb)
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Klein, A., Gralnek, I.M. (2016). Hemostasis of Acute Nonvariceal Upper Gastrointestinal Bleeding. In: Wong Kee Song, L., Gorospe, E., Baron, T. (eds) GI Endoscopic Emergencies. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3085-2_11
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DOI: https://doi.org/10.1007/978-1-4939-3085-2_11
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