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Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes

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Discovering and Developing Molecules with Optimal Drug-Like Properties

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 15))

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Abstract

The discovery environment is characterized by short timelines, scarce supplies of drug, a wide range of chemical space, suboptimal compounds, and the need to execute in a parallel fashion. These realities in turn can place severe restrictions on the options available to the development and implementation of drug delivery strategies. While one would expect the contrary, these realities do not preclude the use of development-stage formulation technologies, however. The key to success is to adapt the approach appropriately and to recognize that some requirements (e.g., stability, safety, scalability, etc.) are actually relaxed. This chapter shows that in some cases the adaptation is a miniaturization of process and characterization, whereas in other instances it involves using a technology in a less commonly encountered form. The chapter begins by describing the unique requirements of discovery, and how they differ from those in later development. A number of drug formulation and delivery approaches are then introduced, and their application to discovery described in some detail.

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Authors and Affiliations

  1. Discovery Pharmaceutics, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT, 06492, USA

    Roy J. Haskell

  2. Discovery Pharmaceutics, Bristol-Myers Squibb, Lawrenceville, NJ, USA

    Kimberly A. Foster & Ching Kim Tye

  3. Bend Research, A Division of Capsugel Dosage Form Solutions, Bend, OR, USA

    Michael Morgen

Authors
  1. Roy J. Haskell
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  2. Kimberly A. Foster
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  3. Ching Kim Tye
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  4. Michael Morgen
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Corresponding author

Correspondence to Roy J. Haskell .

Editor information

Editors and Affiliations

  1. Pharmaceutical Sciences & Clinical Supply, Merck & Co, Inc., West Point, Pennsylvania, USA

    Allen C Templeton

  2. Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, USA

    Stephen R. Byrn

  3. Discovery Pharmaceutics, Bristol-Myers Squibb, Wallingford, Connecticut, USA

    Roy J Haskell

  4. Department of Medicinal Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas, USA

    Thomas E. Prisinzano

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Haskell, R.J., Foster, K.A., Tye, C.K., Morgen, M. (2015). Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes. In: Templeton, A., Byrn, S., Haskell, R., Prisinzano, T. (eds) Discovering and Developing Molecules with Optimal Drug-Like Properties. AAPS Advances in the Pharmaceutical Sciences Series, vol 15. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1399-2_3

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