Abstract
Lack of agreement in defining 4-aminoquinoline retinopathy has impeded progress in understanding and preventing the condition. There are stages of retinopathy, but unclear boundaries separate them. An international working group to standardize definitions would help lay the foundation for clearer communication and synthesis of knowledge.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- 4AQ:
-
4-Aminoquinoline (chloroquine or hydroxychloroquine)
- 4AQR:
-
4-Aminoquinoline retinopathy
- FA:
-
Fluorescein angiography
- HC:
-
Hydroxychloroquine
- mfERG:
-
Multifocal electroretinogram
- RPE:
-
Retinal pigment epithelium
- SAP:
-
Standard automated perimetry
- SD-OCT:
-
Spectral domain optical coherence tomography
References
Bergholz R, Schroeter J, Ruther K. Evaluation of risk factors for retinal damage due to chloroquine and hydroxychloroquine. Br J Ophthalmol. 2010;94:1637–42.
Easterbrook M. Long-term course of antimalarial maculopathy after cessation of treatment. Can J Ophthalmol. 1992;27:237–9.
Hanna B, Holdeman NR, Tang RA, Schiffman JS. Retinal toxicity secondary to Plaquenil therapy. Optometry. 2008;79:90–4.
Maksymowych W, Russell AS. Antimalarials in rheumatology: efficacy and safety. Semin Arthritis Rheum. 1987;16:206–21.
Dubois EL. Antimalarials in the management of discoid and systemic lupus erythematosus. Semin Arthritis Rheum. 1978;8:33–51.
Marmor MF. The dilemma of hydroxychloroquine screening: new information from the multifocal ERG. Am J Ophthalmol. 2005;140:894–5.
Morsman CDG, Livesey SJ, Richards IM, Jessop JD, Mills PV. Screening for hydroxychloroquine retinal toxicity: is it necessary? Eye. 1990;4:572–6.
Henkind P, Carr RE, Siegel IM. Early chloroquine retinopathy: clinical and functional findings. Arch Ophthalmol. 1964;71:157–65.
Okun E, Gouras P, Bernstein H, von Sallmann L. Chloroquine retinopathy-A report of eight cases with ERG and Dark-Adaptation findings. Arch Ophthalmol. 1963;63:93–105.
Browning DJ. Reply to Impact of the revised American Academy of Ophthalmology guidelines regarding hydroxychloroquine screening on actual practice. Am J Ophthalmol. 2013;156:410–1.
Lyons JS, Severns ML. Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity: a review. Doc Ophthalmol. 2009;118:29–36.
Browning DJ. Impact of the revised American academy of ophthalmology guidelines regarding hydroxychloroquine screening on actual practice. Am J Ophthalmol. 2013;155:418–28.
Marmor MF. Efficient and effective screening for hydroxychloroquine toxicity. Am J Ophthalmol. 2013;155:413–4.
Jones SK. Ocular toxicity and hydroxychloroquine: guidelines for screening. Br J Dermatol. 1999;140:3–7.
Mititelu M, Wong BJ, Brenner M, Bryar PJ, Jampol LM, Fawzi AA. Progression of hydroxychloroquine toxic effects after drug therapy cessation. New evidence from multimodal imaging. Arch Ophthalmol. 2013;131:1187–97.
Neubauer AS, Samari-Kermani K, Schaller U, Welge-Luben U, Rudolph G, Berninger T. Detecting chloroquine retinopathy: electro-oculogram versus color vision. Br J Ophthalmol. 2003;87:902–8.
Kellner U, Kraus H, Foerster MH. Multifocal ERG in chloroquine retinopathy: regional variance in retinal dysfunction. Graefes Arch Clin Exp Ophthalmol. 2000;238:94–7.
Angi M, Romano V, Valldeperas X, Romano F, Romano M. Macular sensitivity changes for detection of chloroquine toxicity in asymptomatic patient. Int Ophthalmol. 2010;30:195–7.
Michaelides M, Stover NB, Francis PJ, Weleber RG. Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy. Arch Ophthalmol. 2011;129:30–9.
Rosenthal AR, Kolb H, Bergsma D, Huxsoll D, Hopkins JL. Chloroquine retinopathy in the rhesus monkey. Invest Ophthalmol Vis Sci. 1978;17:1158–75.
Kobak S, Deveci H. Retinopathy due to antimalarial drugs in patients with connective tissue diseases: are they so innocent? A single center retrospective study. Int J Rheum Dis. 2010;13:e11–5.
Sataline LR, Farmer H. Medical Intelligence-Impaired vision after prolonged chloroquine therapy. N Engl J Med. 1962;266:346–7.
Marks JS, Power BJ. Is chloroquine obsolete in treatment of rheumatic disease? Lancet. 1979;1:371–3.
Mills PV, Beck M, Power BJ. Assessment of the retinal toxicity of hydroxychloroquine. Trans Ophthalmol Soc U K. 1981;101:109–13.
Shinjo SK, Junior OOM, Tizziani VAP, Morita C, Kochen JAL, Takahashi WY, Laurindo IMM. Chloroquine-induced bull’s eye maculopathy in rheumatoid arthritis: related to disease duration? Clin Rheumatol. 2007;26:1248–53.
Banks CN. Melanin: blackguard or red herring? Another look at chloroquine retinopathy. Aust N Z J Ophthalmol. 1987;15:365–70.
Rynes RI. Ophthalmologic safety of long-term hydroxychloroquine sulfate treatment. Am J Med. 1983;75:35–9.
Wolfe F, Marmor MF. Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Care Res. 2010;62:775–84.
Shearer RV, Dubois EL. Ocular changes induced by long-term hydroxychloroquine (Plaquenil) therapy. Am J Ophthalmol. 1967;64:245–52.
Yam JCS, Kwok AKH. Ocular toxicity of hydroxychloroquine. Hong Kong Med J. 2006;12:294–304.
Warner AE. Early hydroxychloroquine macular toxicity. Arthritis Rheum. 2001;44:1959–61.
Graniewski-Wijnands HS, Van Lith GHM, Vijfvinkel-Bruinenga S. Ophthalmological examination of patients taking chloroquine. Doc Ophthalmol. 1979;48:231–4.
Weise EE, Yannuzzi LA. Ring maculopathies mimicking chloroquine retinopathy. Am J Ophthalmol. 1974;78:204–10.
Araiza-Casillas R, Cardenas F, Morales Y, Cardiel MH. Factors associated with chloroquine-induced retinopathy in rheumatic diseases. Lupus. 2004;13:119–24.
Maturi RK, Yu M, Weleber RG. Multifocal electroretinographic evaluation of long-term hydroxychloroquine users. Arch Ophthalmol. 2004;122:973–81.
Carr RE, Henkind P, Rothfield N, Siegel IM. Ocular toxicity of antimalarial drugs-long-term follow-up. Am J Ophthalmol. 1968;66:738–44.
Easterbrook M. The ocular safety of hydroxychloroquine. Semin Arthritis Rheum. 1993;23:62–7.
Easterbrook M. Ocular effects and safety of antimalarial agents. Am J Med. 1988;85:23–9.
Finbloom DS, Silver K, Newsome DA, Gunkel R. Comparison of hydroxychloroquine and chloroquine use and the development of retinal toxicity. J Rheumatol. 1985;12:692–4.
Johnson MW, Vine AK. Hydroxychloroquine therapy in massive total doses without retinal toxicity. Am J Ophthalmol. 1987;104:139–44.
Bernstein H. Ocular safety of hydroxychloroquine sulfate (Plaquenil). South Med J. 1992;85:274–9.
Mavrikakis I, Sfikakis PP, Mavrikakis E, Rougas K, Nikolaou A, Kostopoulos C, Mavrikakis M. The incidence of irreversible retinal toxicity in patients treated with hydroxychloroquine—a reappraisal. Ophthalmology. 2003;110:1321–6.
Elder M, Rahman AMA. Early paracentral visual field loss in patients taking hydroxychloroquine. Arch Ophthalmol. 2006;124:1729–33.
Lyons JS, Severns ML. Detection of early hydroxychloroquine retinal toxicity enhanced by ring ratio analysis of multifocal electroretinography. Am J Ophthalmol. 2007;143:801–9.
Ruther K, Foerster J, Berndt S, Schroeter J. Chloroquine/hydroxychloroquine: variability of retinotoxic cumulative doses. Ophthalmologe. 2007;104:875–80.
Anderson C, Blaha GR, Marx JL. Humphrey visual field findings in hydroxychloroquine toxicity. Eye. 2011;25:1535–45.
Chen E, Brown DM, Benz MS, Fish RH, Wong TP, Kim RY, Major JC. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy (the “flying saucer” sign). Clin Ophthalmol. 2010;4:1151–8.
Missner S, Kellner U. Comparison of different screening methods for chloroquine/hydroxychloroquine retinopathy: multifocal electroretinography, color vision, perimetry, ophthalmoscopy, and fluorescein angiography. Graefes Arch Clin Exp Ophthalmol. 2012;250:319–25.
Adam MK, Covert DJ, Stepien KE, Han DP. Quantitative assessment of the 103 hexagon multifocal electroretinogram in detection of hydroxychloroquine retinal toxicity. Br J Ophthalmol. 2012;96:723–9.
Reed H, Campbell AA. Central scotomata following chloroquine therapy. Can Med Assoc J. 1962;86:176–8.
Bernstein HN, Ginsberg J. The pathology of chloroquine retinopathy. Arch Ophthalmol. 1964;71:238–45.
Jabs DA, Nussenblatt RB, Rosenbaum JT, Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005;140:509–16.
Clemons TE, Gillies MC, Chew EY, Bird AC, Peto T, Figueroa M, Harrington MW, The Mac Tel Research Group. The National Eye Institute visual function questionnaire in the Macular Telangiectasia (MacTel) project. Invest Ophthalmol Vis Sci. 2008;49:4340–6.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Browning, D.J. (2014). Definitions of Hydroxychloroquine and Chloroquine Retinopathy. In: Hydroxychloroquine and Chloroquine Retinopathy. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0597-3_4
Download citation
DOI: https://doi.org/10.1007/978-1-4939-0597-3_4
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-0596-6
Online ISBN: 978-1-4939-0597-3
eBook Packages: MedicineMedicine (R0)