Abstract
Parathyromatosis is a rare cause of persistent or recurrent hyperparathyroidism. It is characterized by small nodules and nests of hyperfunctioning parathyroid tissue in soft tissue caused by seeding or implantation of parathyroid tissue during surgical removal or by overgrowth of embryologic nests of parathyroid tissue left behind in development. Parathyromatosis is more common in females, in the fifth to sixth decade, and in end-stage renal disease. Differentiating parathyromatosis from parathyroid carcinoma may be difficult, but patients with parathyroid carcinoma usually have higher serum calcium levels (≥14 mg/dL) and may have a palpable neck mass. Serum calcium levels may overlap in benign and malignant parathyroid disease; thus, careful histologic examination is required to separate these entities.
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Fernandez-Ranvier GG, et al. Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis? Cancer. 2007;110(2):255–64.
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© 2014 Springer Science+Business Media New York
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Erickson, L.A. (2014). Parathyromatosis. In: Atlas of Endocrine Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0443-3_18
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DOI: https://doi.org/10.1007/978-1-4939-0443-3_18
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