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Studies in Diabetes pp 37–47Cite as

Complications in the Coronary Circulation Associated with Diabetes

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Abstract

Diabetes substantially increases the risk of developing coronary disease. Several factors associated with diabetes promote increased oxidative stress and endothelial dysfunction. In the coronary microcirculation, endothelial dysfunction causes chronic vasodilation that leads to increased capillary pressure and hyperperfusion, which in turn leads to morphologic changes that narrow the lumen, and limits the ability of the diabetic coronary circulation to increase myocardial perfusion to meet an increase in myocardial nutrient demand. This chapter summarizes some of the key areas of diabetic complications associated with diabetes in the coronary circulation. A better understanding of underlying microvascular and endothelial pathophysiology associated with diabetes would advance development of new targets for prevention and treatment of vascular complications associated with the disease. Future research should focus on areas to improve strategies to prevent and treat diabetes and its complications at the molecular, cellular, organ, animal, and population levels.

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Author information

Authors and Affiliations

  1. Iowa City Veteran Affairs Health Care System and Cardiovascular Diseases Division, Department of Internal Medicine, University of Iowa, Iowa City, IA, 52246, USA

    Christine L. Oltman

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  1. Christine L. Oltman
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Editor information

Editors and Affiliations

  1. Louisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA

    Irina Obrosova

  2. Centre for Endocrinology and Metabolism, University of Brimingham, School of Clinical and Experimental Medicine, Birmingham, United Kingdom

    Martin J. Stevens

  3. Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa, USA

    Mark A. Yorek

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Oltman, C.L. (2014). Complications in the Coronary Circulation Associated with Diabetes. In: Obrosova, I., Stevens, M., Yorek, M. (eds) Studies in Diabetes. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4899-8035-9_3

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