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Studies in Diabetes pp 237–261Cite as

Oxidative Stress in Diabetes Mellitus and Possible Interventions

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Abstract

A substantial amount of evidence has demonstrated that diabetes is highly associated with oxidative stress. The unifying theory that hyperglycemia-induced elevations in superoxide production underlie the activation of many pathways involved in the onset, progression, and pathological consequences of diabetes naturally raised an interest in the role of antioxidant treatment. In this chapter, after analyzing the molecular mechanisms of the excessive oxidative stress in diabetes, we will discuss the potential therapeutic interventions including pharmaceutical agents, diet, and exercise.

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Author information

Authors and Affiliations

  1. Diabetes Center, First Propeudetic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, American Hellenic Educational Progressive Association Hospital, S. Kyriakidi 1, 54636, Thessaloniki, Greece

    Triantafyllos Didangelos

  2. Internal Medicine and Diabetes Department, Salamis Naval Hospital, Salamis, Greece

    John Doupis

  3. Microcirculation Laboratory and Joslin-Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center and Harvard Medical School, West Campus, One Deaconess Road, Boston, MA, 02215, USA

    Aristidis Veves

Authors
  1. Triantafyllos Didangelos
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  2. John Doupis
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  3. Aristidis Veves
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Corresponding author

Correspondence to Aristidis Veves .

Editor information

Editors and Affiliations

  1. Louisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA

    Irina Obrosova

  2. Centre for Endocrinology and Metabolism, University of Brimingham, School of Clinical and Experimental Medicine, Birmingham, United Kingdom

    Martin J. Stevens

  3. Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa, USA

    Mark A. Yorek

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Didangelos, T., Doupis, J., Veves, A. (2014). Oxidative Stress in Diabetes Mellitus and Possible Interventions. In: Obrosova, I., Stevens, M., Yorek, M. (eds) Studies in Diabetes. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4899-8035-9_12

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