Abstract
Neural tissues have a complex microstructure, and this is reflected in their mechanical properties. Both brain and spinal cord tissues are heterogeneous, with white and grey matter regions having different constituents and structural arrangements. This gives rise to the complex, non-linearly viscoelastic mechanical behaviour of these tissues.
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References
Assaf Y, Pasternak O. Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J Mol Neurosci. 2008;34(1):51–61.
Bain AC, Shreiber DI, Meaney DF. Modeling of microstructural kinematics during simple elongation of central nervous system tissue. J Biomech Eng. 2003;125:798.
Bilston LE, editor. Neural tissue biomechanics. Studies in mechanobiology, tissue engineering and biomaterials. Berlin: Springer; 2011.
Bilston LE, Thibault LE. The mechanical properties of the human cervical spinal cord in vitro. Ann Biomed Eng. 1996;24(1):67–74.
Bilston LE, Liu Z, Phan-Thien N. Linear viscoelastic properties of bovine brain tissue in shear. Biorheology. 1997;34(6):377–85.
Bilston LE, Liu Z, Phan-Thien N. Large strain behaviour of brain tissue in shear: some experimental data and differential constitutive model. Biorheology. 2001;38(4):335–45.
Brands DWA, Peters GWM, Bovendeerd PHM. Design and numerical implementation of a 3-D non-linear viscoelastic constitutive model for brain tissue during impact. J Biomech. 2004;37(1):127–34.
Cater HL, Sundstrom LE, Morrison B. Temporal development of hippocampal cell death is dependent on tissue strain but not strain rate. J Biomech. 2006;39(15):2810–8.
Cheng S, Bilston LE. Unconfined compression of white matter. J Biomech. 2007;40(1):117–24.
Cheng S, Bilston LE. Computational model of the cerebral ventricles in hydrocephalus. J Biomech Eng. 2010;132:054501.
Cheng S, Clarke EC, Bilston LE. Rheological properties of the tissues of the central nervous system: a review. Med Eng Phys. 2008;30(10):1318–37.
Chinzei K, Miller K. Compression of swine brain tissue: experiment in vitro. J Mech Eng Lab. 1996;50(4):106–15.
Clarke EC, Bilston LE. Contrasting biomechanics and neuropathology of spinal cord injury in neonatal and adult rats following vertebral dislocation. J Neurotrauma. 2008;25(7):817–32.
Clarke EC, McNulty PA, Macefield VG, Bilston LE. Mechanically evoked sensory and motor responses to dynamic compression of the ulnar nerve. Muscle Nerve. 2007;35(3):303–11.
Clarke EC, Choo AM, Liu J, Lam CK, Bilston LE, Tetzlaff W, et al. Anterior fracture-dislocation is more severe than lateral: a biomechanical and neuropathological comparison in rat thoracolumbar spine. J Neurotrauma. 2008;25(4):371–83.
Clarke EC, Cheng S, Bilston LE. The mechanical properties of neonatal rat spinal cord in vitro, and comparisons with adult. J Biomech. 2009;42(10):1397–402.
Clarke E, Cheng S, Green M, Sinkus R, Bilston L. Using static preload with magnetic resonance elastography to estimate large strain viscoelastic properties of bovine liver. J Biomech. 2011;44(13):2461–5.
Cloots RJH, van Dommelen JAW, Nyberg T, Kleiven S, Geers MGD. Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy. Biomech Model Mechanobiol. 2011;10(3):413–22.
Coats B, Margulies SS. Material properties of porcine pariet al cortex. J Biomech. 2006;39(13):2521–5.
Darvish KK, Crandall JR. Nonlinear viscoelastic effects in oscillatory shear deformation of brain tissue. Med Eng Phys. 2001;23(9):633–45.
Dilley A, Lynn B, Pang SJ. Pressure and stretch mechanosensitivity of peripheral nerve fibres following local inflammation of the nerve trunk. Pain. 2005;117(3):462–72.
Elkin BS, Azeloglu EU, Costa KD, Morrison 3rd B. Mechanical heterogeneity of the rat hippocampus measured by atomic force microscope indentation. J Neurotrauma. 2007;24(5):812–22.
Fallenstein GT, Hulce VD, Melvin JW. Dynamic mechanical properties of human brain tissue. JBiomech. 1969;2(3):217–26.
Ferry J. Viscoelastic properties of polymers. New York: Wiley; 1980.
Fiford RJ. Biomechanics of spinal cord injury in a novel rat model. PhD thesis, University of Sydney; 2006.
Fiford RJ, Bilston LE. The mechanical properties of rat spinal cord in vitro. J Biomech. 2005;38(7):1509–15.
Fiford RJ, Bilston LE, Waite P, Lu J. A vertebral dislocation model of spinal cord injury in rats. JNeurotrauma. 2004;21(4):451–8.
Franceschini G, Bigoni D, Regitnig P, Holzapfel GA. Brain tissue deforms similarly to filled elastomers and follows consolidation theory. J Mech Phys Solids. 2006;54(12):2592–620.
Galford JE, McElhaney JH. A viscoelastic study of scalp, brain, and dura. J Biomech. 1970;3: 211–21.
García J, Smith J. A biphasic hyperelastic model for the analysis of fluid and mass transport in brain tissue. Ann Biomed Eng. 2009;37(2):375–86.
Gennarelli TA, Thibault LE. Biomechanics of acute subdural hematoma. J Trauma. 1982;22(8):680–6.
Gennarelli TA, Thibault LE, Adams JH, Graham DI, Thompson CJ, Marcincin RP. Diffuse axonal injury and traumatic coma in the primate. Ann Neurol. 1982;12(6):564–74.
Green MA, Bilston LE, Sinkus R. In vivo brain viscoelastic properties measured by magnetic resonance elastography. NMR Biomed. 2008;21(7):755–64.
Green MA, Bilston LE, van Houten E, Sinkus R, editors. In-vivo brain viscoelastic anisotropic properties using DTI and MR-elastography. In: Proceedings of the 17th ISMRM; Honolulu, HI; 2009.
Han SE, Lin CSY, Boland RA, Bilston LE, Kiernan MC. Changes in human sensory axonal excitability induced by focal nerve compression. J Physiol. 2010;588(10):1737–45.
Hollander Y, Durban D, Lu X, Kassab GS, Lanir Y. Experimentally validated microstructural 3D constitutive model of coronary arterial media. J Biomech Eng. 2011a;133(3):031007.
Hollander Y, Durban D, Lu X, Kassab GS, Lanir Y. Constitutive modeling of coronary arterial media—comparison of three model classes. J Biomech Eng. 2011b;133(6):061008.
Horowitz A, Lanir Y, Yin FC, Perl M, Sheinman I, Strumpf RK. Structural three-dimensional constitutive law for the passive myocardium. J Biomech Eng. 1988;110(3):200–7.
Hrapko M, van Dommelen JAW, Peters GWM, Wismans JSHM. The mechanical behaviour of brain tissue: large strain response and constitutive modelling. Biorheology. 2006;43(5): 623–36.
Hubbard RD, Chen Z, Winkelstein BA. Transient cervical nerve root compression modulates pain: load thresholds for allodynia and sustained changes in spinal neuropeptide expression. J Biomech. 2008;41(3):677–85.
Ichihara K, Taguchi T, Shimada Y, Sakuramoto I, Kawano S, Kawai S. Gray matter of the bovine cervical spinal cord is mechanically more rigid and fragile than the white matter. JNeurotrauma. 2001;18(3):361–7.
Jamin Y, Boult JK, Bamber JC, Sinkus R, Robinson SP, editors. High resolution magnetic resonance elastography of orthotopic murine glioma in vivo. Montreal: ISMRM; 2011.
Kruse SA, Rose GH, Glaser KJ, Manduca A, Felmlee JP, Jack Jr CR, et al. Magnetic resonance elastography of the brain. Neuroimage. 2008;39(1):231–7.
Kwan MK, Wall EJ, Weiss JA, Rydevik BL, Garfin SR, Woo SL-Y. Biomechanical analysis of rabbit peripheral nerve: in situ stresses and strains. ASME Biomech Symp AMD. 1989;98: 109–12.
Kwan MK, Wall EJ, Massie J, Garfin SR. Strain, stress and stretch of peripheral nerve rabbit experiments in vitro and in vivo. Acta Orthop. 1992;63(3):267–72.
Lanir Y. Biaxial stress-relaxation in skin. Ann Biomed Eng. 1976;4(3):250–70.
Lanir Y. Structure-strength relations in mammalian tendon. Biophys J. 1978;24(2):541–54.
Lanir Y. A structural theory for the homogeneous biaxial stress-strain relationships in flat collagenous tissues. J Biomech. 1979;12(6):423–36.
Lanir Y. A microstructure model for the rheology of mammalian tendon. J Biomech Eng. 1980;102(4):332–9.
Lanir Y. Constitutive equations for the lung tissue. J Biomech Eng. 1983a;105(4):374–80.
Lanir Y. Constitutive equations for fibrous connective tissues. J Biomech. 1983b;16(1):1–12.
Lanir Y. Plausibility of structural constitutive equations for swelling tissues—implications of the C-N and S-E conditions. J Biomech Eng. 1996;118(1):10–6.
Lanir Y. Physical mechanisms of soft tissues rheological properties. In: Chien S, editor. Biomechanics: from molecules to man: tributes to Yuan-Cheng Fung on his 90th birthday. Singapore: World Scientific; 2009. p. 1–12.
Lokshin O, Lanir Y. Viscoelasticity and preconditioning of rat skin under uniaxial stretch: microstructural constitutive characterization. J Biomech Eng. 2009;131(3):031009.
Lu Y-B, Franze K, Seifert G, Steinhäuser C, Kirchhoff F, Wolburg H, et al. Viscoelastic properties of individual glial cells and neurons in the CNS. Proc Natl Acad Sci. 2006;103(47):17759–64.
Miller K. Constitutive model of brain tissue suitable for finite element analysis of surgical procedures. J Biomech. 1999;32(5):531–7.
Miller K, Chinzei K. Mechanical properties of brain tissue in tension. J Biomech. 2002;35(4): 483–90.
Miller K, Chinzei K, Orssengo G, Bednarz P. Mechanical properties of brain tissue in-vivo: experiment and computer simulation. J Biomech. 2000;33(11):1369–76.
Murphy MC, Huston J, Jack CR, Glaser KJ, Manduca A, Felmlee JP, et al. Decreased brain stiffness in Alzheimer’s disease determined by magnetic resonance elastography. J Magn Reson Imaging. 2011;34(3):494–8.
Nicholson KJ, Winkelstein BA. Nerve and nerve root biomechanics. In: Bilston LE, editor. Neural tissue biomechanics. Studies in mechanobiology, tissue engineering and biomaterials. Springer: Berlin; 2011. p. 203–29.
Nicolle S, Lounis M, Willinger R, Palierne JF. Shear linear behavior of brain tissue over a large frequency range. Biorheology. 2005;42(3):209–23.
Ning X, Zhu Q, Lanir Y, Margulies SS. A transversely isotropic viscoelastic constitutive equation for brainstem undergoing finite deformation. J Biomech Eng. 2006;128(6):925–33.
Pena A, Bolton MD, Whitehouse H, Pickard JD. Effects of brain ventricular shape on periventricular biomechanics: a finite-element analysis. Neurosurgery. 1999;45(1):107.
Phillips JB, Smit X, De Zoysa N, Afoke A, Brown RA. Peripheral nerves in the rat exhibit localized heterogeneity of tensile properties during limb movement. J Physiol. 2004;557(3):879–87.
Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology. 1996;201(3):637–48.
Povlishock JT, Christman CW. The pathobiology of traumatically induced axonal injury in animals and humans: a review of current thoughts. J Neurotrauma. 1995;12(4):555–64.
Prange MT, Margulies SS. Regional, directional, and age-dependent properties of the brain undergoing large deformation. J Biomech Eng. 2002;124(2):244–52.
Qin EC, Sinkus R, Geng G, Cheng S, Green M, Rae CD, Bilston LE. Combining MR elastography and diffusion tensor imaging for the assessment of anisotropic mechanical properties: a phantom study. J Magn Reson Imaging. 2013;37:217–26.
Rothman SM, Winkelstein BA. Chemical and mechanical nerve root insults induce differential behavioral sensitivity and glial activation that are enhanced in combination. Brain Res. 2007;1181:30–43.
Rothman SM, Nicholson KJ, Winkelstein BA. Time-dependent mechanics and measures of glial activation and behavioral sensitivity in a rodent model of radiculopathy. J Neurotrauma. 2010;27(5):803–14.
Sack I, Beierbach B, Hamhaber U, Klatt D, Braun J, Sack I, et al. Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography. NMR Biomed. 2008;21(3): 265–71.
Sack I, Beierbach B, Wuerfel J, Klatt D, Hamhaber U, Papazoglou S, et al. The impact of aging and gender on brain viscoelasticity. Neuroimage. 2009;46(3):652–7.
Schregel K, Wuerfel née Tysiak E, Garteiser. P, Gemeinhardt I, Prozorovski T, Aktas O, et al. Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography. Proc Natl Acad Sci U S A. 2012;109(17):6650–5.
Shreiber D, Hao H, Elias R. Probing the influence of myelin and glia on the tensile properties of the spinal cord. Biomech Model Mechanobiol. 2009;8(4):311–21.
Singh A, Lu Y, Chen C, Cavanaugh JM. Mechanical properties of spinal nerve roots subjected to tension at different strain rates. J Biomech. 2006;39(9):1669–76.
Singh A, Kallakuri S, Chen C, Cavanaugh JM. Structural and functional changes in nerve roots due to tension at various strains and strain rates: an in-vivo study. J Neurotrauma. 2009;26(4): 627–40.
Streitberger K-J, Wiener E, Hoffmann J, Freimann FB, Klatt D, Braun J, et al. In vivo viscoelastic properties of the brain in normal pressure hydrocephalus. NMR Biomed. 2011;24(4):385–92.
Tanoue M, Yamaga M, Ide J, Takagi K. Acute stretching of peripheral nerves inhibits retrograde axonal transport. J Hand Surg Br. 1996;21(3):358–63.
Tsuchiya K, Katase S, Fujikawa A, Hachiya J, Kanazawa H, Yodo K. Diffusion-weighted MRI of the cervical spinal cord using a single-shot fast spin-echo technique: findings in normal subjects and in myelomalacia. Neuroradiology. 2003;45(2):90–4.
Velardi F, Fraternali F, Angelillo M. Anisotropic constitutive equations and experimental tensile behavior of brain tissue. Biomech Model Mechanobiol. 2006;5(1):53–61.
Wang C, Garcia M, Lu X, Lanir Y, Kassab GS. Three-dimensional mechanical properties of porcine coronary arteries: a validated two-layer model. Am J Physiol Heart Circ Physiol. 2006;291(3):H1200–9.
Wittek A, Hawkins T, Miller K. On the unimportance of constitutive models in computing brain deformation for image-guided surgery. Biomech Model Mechanobiol. 2009;8(1):77–84.
Yang KH, Mao H, Wagner C, Zhu F, Chou CC, King AI. Modeling of the brain for injury prevention. In: Bilston LE, editor. Neural tissue biomechanics. Studies in mechanobiology, tissue engineering and biomaterials. Berlin: Springer; 2011. p. 69–120.
Zhang J, Green MA, Sinkus R, Bilston LE. Viscoelastic properties of human cerebellum using magnetic resonance elastography. J Biomech. 2011;44(10):1909–13.
Acknowledgment
Lynne Bilston is supported by a National Health and Medical Research Council of Australia Senior Research Fellowship.
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Bilston, L.E. (2016). The Influence of Microstructure on Neural Tissue Mechanics. In: Kassab, G., Sacks, M. (eds) Structure-Based Mechanics of Tissues and Organs. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7630-7_1
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DOI: https://doi.org/10.1007/978-1-4899-7630-7_1
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