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Bone Drugs in Pediatrics pp 37–65Cite as

Paediatric Bone Physiology and Monitoring the Safety and Efficacy of Bone Drugs in Children

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Abstract

Many childhood diseases and their treatments can have adverse effects on the developing skeleton and the accrual of bone mass essential for normal adult bone health. Treatment with anti-resorptive and bone anabolic drugs can reduce such detrimental effects, but may also adversely affect bone development. Thus, in paediatric patients it is prudent to assess the skeleton carefully prior to commencing treatment, and to perform regular re-evaluation to monitor skeletal responses and to rapidly identify adverse events. The longitudinal follow-up of adult patients is relatively straightforward but similar longitudinal evaluation of the developing skeleton in paediatric patients is significantly more difficult and the data interpretation complex. This chapter highlights the underlying physiological basis for these difficulties and describes the modalities used for monitoring the efficacy and safety of skeletal pharmacology in paediatric patients.

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Acknowledgements

Many thanks to Dr. F. Rauch, Dr. J. Allgrove and Dr. C. Wei for reading the manuscript and their helpful suggestions.

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Authors and Affiliations

  1. Department of Medicine, Molecular Endocrinology Group, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK

    John G. Logan Ph.D. & J. H. Duncan Bassett M.D.

  2. Department of Endocrinology, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1N 3JH, UK

    Moira S. Cheung MBBS, MRCPCH, MSc, PhD

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  1. John G. Logan Ph.D.
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  2. J. H. Duncan Bassett M.D.
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  3. Moira S. Cheung MBBS, MRCPCH, MSc, PhD
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Correspondence to John G. Logan Ph.D. .

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Editors and Affiliations

  1. Department of Orthopaedic Surgery, University of Texas Medical Branch, Galveston, Texas, USA

    Gordon L. Klein

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Logan, J.G., Bassett, J.H.D., Cheung, M.S. (2014). Paediatric Bone Physiology and Monitoring the Safety and Efficacy of Bone Drugs in Children. In: Klein, G. (eds) Bone Drugs in Pediatrics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7436-5_4

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  • DOI: https://doi.org/10.1007/978-1-4899-7436-5_4

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