Monomers and Polymers from Nalidixic Acid — Synthesis, Characterization and Hydrolysis Study
- Malay GhoshAffiliated withDepartment of Chemistry and Chemical Engineering, Stevens Institute of Technology
Over the past few years, quinolone derivatives, in particular nalidixic acid and its structural analogues have proven themselves as potential antibacterial agents. These compounds are highly effective against gram negative bacteria in addition to their activity against gram positive organisms. The synthesis of polymeric derivatives of quinolone antibacterials and their biological activities are not available in the literature. In order to prepare safer, potential antibacterial agents, we planned to prepare macromolecules containing quinolones as pendent moieties. This paper will report the synthesis of three new monomers and polymers from nalidixic acid. Their characterization and hydrolysis study at pH 7.4 will also be described.
- Monomers and Polymers from Nalidixic Acid — Synthesis, Characterization and Hydrolysis Study
- Book Title
- Progress in Biomedical Polymers
- pp 335-345
- Print ISBN
- Online ISBN
- Springer US
- Copyright Holder
- Springer Science+Business Media New York
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- Editor Affiliations
- 1. Department of Chemistry, Youngstown State University
- 2. Atrix Laboratories, Inc.
- Malay Ghosh (3)
- Author Affiliations
- 3. Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Hoboken, NJ, 07030, USA
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