Abstract
The field of aggression research would profit tremendously if research on animals and humans interacted as intensively as it happens in the field of anxiety, depression, epilepsy and other medically defined fields. The multiple emotional, political, and historical reasons why integration in the field of aggression research is comparatively modest, have been reviewed1. It is clear that the association between animal and human aggression in general is an emotional topic that raises a series of concerns. In contrast, pathological forms of human aggression are more easily perceived as being caused by “biological” malfunctions. Laboratory research has contributed substantially to the understanding of biological bases of aggressiveness. Aggression controlling brain centers, neurotransmitter systems, and hormonal factors have been identified2–9. Based on this information, procedures have been developed to “cure” pathological forms of violence including surgery5, 10, 11 and drug treatment12–16. We argue here for the involvement of stress hormones (glucocorticoids) in pathological forms of aggression in both animals and humans. We suggest that experimentally induced perturbations in glucocorticoid synthesis can be used as animal models for abnormal human violence. Such models can also be used for testing the anti-aggressive drugs.
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References
Blanchard D.C., Hebert, M. and Blanchard. R.J. 1999, Continuity vs. political correctness: animal models and human aggression. HFG Review 3: 3–12.
Simon, N.G. and Coccaro, E.F., 1999, Human aggression: what’s animal research got to do with it? HFG Review 3: 13–20.
Siegel, A., Roeling, T.A., Gregg, T.R. and Kruk, M.R., 1999, Neuropharmacology of brainstimulation-evoked aggression. Neurosci. Biobehay. Rev. 23: 359–389.
Roeling, T.A., Veening, J.G., Kruk, M.R-, Peters, J.P., Vermelis, M.E. and Nieuwenhuys, R. 1994, Efferent connections of the hypothalamic “aggression area” in the rat. Neuroscience 59: 1001–1024.
Ramamurthi, B., 1988, Stereotaxic operation in behaviour disorders. Amygdalectomy and hypothalatomy. Acta Neurochirurgica, Suppl. 44: 152–157.
Miczek, K.A., Mos, J. and Olivier, B., 1989, Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacol. Bull. 25: 399–403.
Haller, J., Makara, G.B. and Kruk, M.R., 1998, Catecholaminergic involvement in the control of aggression: hormones, the peripheral sympathetic, and central noradrenergic systems. Neurosci. Biobehay. Rev. 22: 85–97.
Gandelman, R., 1980, Gonadal hormones and the induction of intraspecific fighting in mice. Neurosci. Biobehay. Rev. 4: 133–140
Haller, J., Halasz, J., Makara, G.B. and Kruk, M.R, 1998, Acute effects of glucocorticoids: behavioral and pharmacological perspectives. Neurosci. Biobehay. Rev. 23: 337–344. l0. 10 Valenstein, E.S., 1973, Brain Control. Wiley, New York.
Sachdev, P., Smith, J.S., Matheson, J., Last, P. and Blumbergs, P., 1992, Amygdalohippocampectomy for pathological aggression. Australian New Zealand J. Psychiatr. 26: 671–676.
Sheard, M.J., Marini, J., Bridges, C. and Wapner, A., 1976, The effect of lithium on impulsive aggressive behavior in man. Amer..1. Psychiatry 13: 1409–1413.
Coccaro. E.F. and Kavoussi RJ., 1997, Fluoxetine and impulsive behavior in personality disordered subjects. Arch Gen. Psychiatry 54: 1081–1088.
Olivier, B., Mos, J. and Rasmussen, D., 1990, Behavioural pharmacology of the serenic, eltoprazine. Drug Metabol. Drug Interact. 8: 31–83.
Soloff, P.H., George, A., Nathan, RS., Schhultz, P.M. and Perd, J.M., 1986, Paradoxical effects of amitriptyline in borderline patients. Am. J Psychiatry. 143: 1603–1605.
Miczek, K.A., Weerts, E., Haney, M. and Tidey, J., 1994, Neurobiological mechanisms controlling aggression: preclinical developments for pharmacotherapeutic interventions. Neurosci. Biobehay. Rev. 18: 97–110.
Avanzino, G.L., Ermirion, R., Ruggieri, P. and Cogo, C.E., 1984, Effect of microelectrophoretically applied corticosterone on raphe neurons in the rat. Neurosci. Lett. 50: 307–311.
Kennett, G.A., Chaouloff, F., Marcou, M. and Curzon, G., 1986, Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin. Brain Res. 382: 416–421
Liu, X., Chun-An, W. and Chen, Y.-Z., 1995, Nongenomic effect of glucocorrticoid on the release of arginine vasopressin from hypothalamic slices in rats. Neuroendocrinology 62: 628–633.
Meijer, O.C. and de Kloet, E.R., 1998, Corticosterone and serotonergic neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity. Crit. Rev. Neurobiol. 12: 1–20.
Miczek, K.A., Thompson, M.L. and Tomatzky, W., 1991, Subordinate animals. Behavioral and physiological adaptations and opioid tolerance. In: Stress. Neurobiology and Neuroendocrinology. ( M.R. Brown, G.F. Koob, C. Rivier, eds.) Dekker, New York, pp. 323–355.
Neckers, L. and Sze, P.Y., 1975, Regulation of 5-hydroxytryptamine metabolism in mouse brain by adrenal glucocorticoids. Brain Res. 93: 123–132.
Sandi, C., Venero, C. and Guaza, C., 1996, Novelty-related rapid locomotor effects of corticosterone in rats. Eur. J Neurosci. 8: 794–800.
Sandi, C., Venero, C. and Guam, C., 1996, Nitric oxide synthesis inhibitors prevent rapid behavioral effects of corticosterone in rats. Neuroendocrinology 63: 446–453.
Scott, L.V. and Dinan, T.G., 1998, Vasopressin and the regulation of hypothalamicpituitary-adrenal axis function: implications for the pathophysiology of depression. Life Sci. 62: 1985–1998.
Sze, P.Y. and lqbal, Z., 1994, Glucocorticooid action on depolarization-dependent calcium influx in brain synaptosomes. Neuroendocrinology 59: 457–465.
Werkman, T.R., Van der Linden, S. and Joels, M., 1997, Corticosteroid effects on sodium and calcium currents in acutelydissociated rat CAI hippocampal neurons. Neuroscience 78: 663–672.
Schuurman, T., 1980, Hormonal correlates of agonistic behaviour in adult male rats. Prog. Brain Res. 53: 415–420.
Haller, J., Kiem, D.T. and Makara, G.B., 1996, The physiology of social conflict in rats: what is particularly stressful? Behay. Neurosci. 110: 353–359.
Brain, P.F., Nowell, N.W. and Wouters, A., 1971, Some relationships between adrenal function and isolation-induced intermale aggression in albino mice. Physiol. Behay. 6: 2729.
Poole, A.E. and Brain, P.F., 1974, Effects of adrenalectomy and treatments of ACTH and glucocorticoids on isolation-induced aggressive behaviour in male albino mice. In: Recent Progress in Brain Research (D.F. Swaab and J.P. Schade, eds.) Elsevier/ North Holland, Amsterdam, Vol 41 pp. 465–472.
Haller, J., Albert I., and Makara, G.B., 1997, Acute Behavioral effects of corticosterone lack specificity but show marked context dependency. J Neuroendocrinol, 9: 515–518.
Hayden-Hixson, D.M. and Ferris, C.F., 1991, Steroid-specific regulation of agonistic responding in the anterior hypothalamus of male hamsters. Physiol Behay. 50: 793–799.
Hayden-Hixson, D.M. and Ferris, C.F., 1991, Cortisol exerts site-, context-and dose-dependent effects on agonistic responding in hamsters. J. Neuroendocrinol. 3: 613–622.
Haller, J., Halasz, J., Mikics, É., Kruk, M.R. and Makara, G.B., 2000, Ultradian corticosterone rhythm and the propensity to behave aggressively in male rats. J Neuroendocrinol. 12: 937–941.
Politch, J.A. and Leshner, Al.,. 1977, Relationship between plasma corticosterone levels and levels of aggressiveness in mice. Physiol. Behay. 19: 775–780.
Leshner, A.L and Politch, J.A., 1979, Hormonal control of submissiveness in mice: irrelevance of the androgens and relevance of the pituitary-adrenal hormones. Physiol. Behay. 22: 531–534.
Haller, J., 1995, Biochemical backgrounds for cost-benefit interrelations in aggression. Neurosci. Biobehay. Rev. 19: 599–604.
Duval, D., Durant, S. and Homo-Delerche F., 1983, Non-genomic effects of steroids. Interactions of steroid molecules with membrane structures and functions. Biochim. Biophys. Acta 737: 409–442.
Falkenstein, E., Norman, A.W. and Wehling, M., 2000, Mannheim classification of nongenomically initiated (rapid) glucocorticoid steroid action(s). J. Clin. Endocrinol. Metab. 85: 2072–2075.
Schmidt, B.M.W., Gerdes, D., Feuring, M., Falkenstein, E., Christ, M. and Wehling, M., 2000, Rapid, nongenomic steroid actions: a new age? Front. Neuroendocrinol. 21: 57–94.
Salvadora, A., Suay, F., Martinez-Sanchis, S., Simon, V.M. and Brain, P.F., 1999, Correlating testosterone and fighting in male participants in judo contests. Physiol. Behay. 68: 205–209.
McBurnett, K., Lahey, B.B., Rathouz, P.J. and Loeber, R., 2000, Low salivary cortisol and persistent aggression in boys referred for disruptive behavior. Arch Gen Psychiatry. 57: 38–43.
van Goozen, S.H., Matthys, W., Cohen-Kettenis, P.T., Gispen-de Wied, C., Wiegant, V.M. and van Engeland, H., 1998, Salivary cortisol and cardiovascular activity during stress in oppositional-defiant disorder boys and normal controls. BioL Psychiatry 43: 53 1539.
Vanyukov, M.M., Moss, H.B., Plail, J.A., Blackson, T., Mezzich, A.C. and Tarter, R.E. Antisocial symptoms in preadolescent boys and in their parents: associations with cortisol. Psychiatry Res. 46: 9–17.
Virkkunen, M., 1985, Urinary free cortisol secretion in habitually violent offenders. Acta Psychiatr. Scand 72: 40–44.
Raine, A., 1993, The Psychopathology of Crime. Academic Press, San Diego.
Banks, T. and Dabbs, J.M. Jr., 1996, Salivary testosterone and cortisol in a delinquent and violent urban subculture. J Soc. Psychos. 136: 49–56.
Dabbs, J.M. Jr., Jurkovic, G.J. and Frady, R.L., 1991, Salivary testosterone and cortisol among late adolescent male offenders. J Abnorm. Child Psycho!. 19: 469–478.
Gerra, G., Avanzini, P., Zaimovic, A., Fertonani, G., Caccavari, R., Delsignore, R, Gardini, F., Talarico, E., Lecchini, R., Maestri, D. and Brambilla, F., 1996, Neurotransmitter and endocrine modulation of aggressive behavior and its components in normal humans. Behay. Brain Res. 81: 19–24.
Gerra, G., Zaimovic, A., Avanzini, P., Chittolini, B., Giucastro, G., Caccavari, R., Palladino, M., Maestri, D., Monica, C., Delsignore, R. and Brambilla, F., 1997, Neurotransmitter-neuroendocrine responses to experimentally induced aggression in humans: influence of personality variable. Psychiatry Res. 66: 33–43.
Haller, J., Schraaf, J. van de and Kruk, M.R., 2001, Deviant forms of aggression in glucocorticoid hyporeactive rats. A model for “pathological” aggression?J Neuroendocrinol in press.
Blanchard, D.C., Hori, K., Rodgers, R.J., Hendrie, C.A. and Blanchard, R.J., 1989, Attenuation of defensive threat and attack in wild rats (Rattus rattus) by benzodiazepines. Psychopharmacology 97: 392–401.
Blanchard, R.J. and Blanchard, D.C., 1981, The organization and modeling of animal aggression. In: The Biology of Aggression ( P.F. Brain, D. Benton, eds.), Sijthoff et Noordhoff, Alphen aan den Rijn (The Netherlands), pp. 529–563.
Parmigiani, S., Brain, P.F., Mainardi, D. and Brunoni, V., 1988, Different patterns of biting attack employed by lactating female mice (Mus domesticus) in encounters with male and female conspecific intruders. J. Comp. Psycho/ 102: 287–293.
Parmigiani, S., Ferrari, P.F. and Palanza, P., 1998, An evolutionary approach to behavioral pharmacology: using drugs to understand proximate and ultimate mechanisms of different forms of aggression in mice. Neurosci. Biobehay. Rev. 23: 143–153.
Benton, L.A. and Yates, F.E., 1990, Ultradian adrenocortical and circulatory oscillations in conscious dogs. Am. J. Physiol. 258: R578 - R590.
Fulkerson, W.J. and Tang, B.Y., 1979, Ultradian and circadian rhythms in the plasma concentration of cortisol in sheep. J. Endocrinol. 81: 135–141.
Holaday, J.W., Martinez, H.M. and Natelson, B.H., 1977, Synchronised ultradian cortisol rhythms in monkeys: persistence during corticotropin infusion. Science 198: 19–21.
Ingram, J.R., Crockford, J.N. and Mathews, L.R., 1999, Ultradian, circadian and seasonal rhythms in cortisol secretion and adrenal responsiveness to ACTH and yarding in unrestrained red deer (Cervus elaphus) stags. J Endocrinos. 162: 289–300.
Lefcourt, A.M., Bitman, J., Kahl, S. and Wood, D.L., 1993, Circadian and ultradian rhythms of peripheral cortisol concentrations in lactating dairy cows. J. Dairy Sci. 76: 2607–2612.
Stupfel, M. and Pavely, A., 1990, Ultradian, circahoral and circadian structures in endothermic vertebrates and humans. Comp. Biochem. Physiol. A 96: 1–1I.
Vance, M.L. and Thomer, M.O., 1989, Fasting alters pulsatile and rhythmic cortisol release in normal man. J. Clin. Endocrinol. Metab. 68: 1013–1018.
Windle, R.J., Wood, S.A., Lightman, S.L. and Ingram, C.D., 1998, The pulsatile characteristics of hypothalamo-pituitary-adrenal activity in female Lewis and Fischer 344 rats and its relationship to differential stress responses. Endocrinology 139: 4044–4052.
Windle, R.J., Wood, S.A., Shanks, N., Lightman, S.L. and Ingram, C.D., 1998, Ultradian rhythm of basal corticosterone release in the female rat: dynamic interaction with the response to acute stress. Endocrinology 139, 443–450.
McElroy, S.L., 1999, Recognition and treatment of DSM-IV intermittent explosive disorder. J. Clin Psychiatry. 60 Supplement: 12–16.
Abelson, J.L. and Curtis, G.C., 1996, Hypothalamic-pituitary-adrenal axis activity in panic disorder. 24-hour secretion of corticotropin and cortisol. Arch. Gen. Psychiatry 53: 323–331.
Branchey, L., Weinberg, U., Branchey, M., Linkowski, P. and Mendlewitz, J., 1982, Simultaneous study of 24-h patterns of melatonin and cortisol secretion in depressed patients. Neuropsychobiology 8: 225–232.
Meier-Koll, A., Bohl, E., Schardl, B. and Novacek, F., 1995, The adaptive significance of social synchronisation of ultradian behavior cycles: a computer model. J Biosoc. Sci. 27: 285–299.
Stutzmann, G.E., McEwen, B.S. and LeDoux, J.E., 1998, Serotonin modulation of sensory inputs to the lateral amygdala: dependency on corticosterone. J. Neurosci. 18: 9529–9538.
Kruk, M.R., 1991, Ethology and pharmacology of hypothalamic aggression in the mt. Neurosci. Biobehay. Rev. 15: 527–538.
Wallman, J., 1999, Serotonin and impulsive aggression: not so fast. HFG Review 3: 21–24.
Colvard, K., 1999, Introduction: The biology of aggression. HFG Review 3: 1–2.
Kuper, A., 1994, The Chosen primate: Human nature and cultural diversity, Harvard University Press, Cambridge (Massachusetts).
Cronk, L., 1999, That complex whole: Culture and the evolution of human behavior. Westview Press, Boulder (Colorado).
Low, B.S., 1999, Why sex matters: A Darwinian look at human behavior. Princeton University Press, Princeton (New Jersey).
Widom, C.S., 1989, The cycle of violence. Science 244: 160–166.
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Haller, J., Kruk, M.R. (2001). Stress hormones and aggression. In: Martinez, M. (eds) Prevention and Control of Aggression and the Impact on its Victims. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6238-9_6
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DOI: https://doi.org/10.1007/978-1-4757-6238-9_6
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