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Transplantation of the Pancreas pp 11–27Cite as

Diabetes Mellitus: Pathogenesis and Natural History

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Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia arising as a consequence of a relative or absolute deficiency of insulin secretion, resistance to insulin action, or both.1,2 Although diabetes mellitus is recognized by its characteristic hyperglycemia, the metabolic derangements are more pervasive, involving altered metabolism of carbohydrates, fats, and proteins. As a function of time and consequent to the metabolic disruption, diabetic patients may suffer the tragic ravages of long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels.

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Authors
  1. Jay S. Skyler
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Editors and Affiliations

  1. Department of Surgery, University of Minnesota, 55455, Minneapolis, Minnesota, USA

    Rainer W. G. Gruessner MD (Professor) & David E. R. Sutherland MD, PhD (Professor) (Professor) &  (Professor)

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Skyler, J.S. (2004). Diabetes Mellitus: Pathogenesis and Natural History. In: Gruessner, R.W.G., Sutherland, D.E.R. (eds) Transplantation of the Pancreas. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4371-5_2

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  • DOI: https://doi.org/10.1007/978-1-4757-4371-5_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-1830-7

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