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Ovarian Cancer pp 61–97Cite as

Early Detection of Ovarian Cancer: Promise and Reality

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 107))

Abstract

One of the most promising approaches to the control of many epithelial malignancies is to detect cancers before they have metastasized. Effective screening strategies have been developed and are widely utilized in clinical practice to detect cervical, breast, prostate and colorectal cancers. In the case of epithelial ovarian cancer, the ability to cure early stage disease provides an attractive rationale for the development of similarly effective screening strategies. Despite the improvement in median survival achieved with contemporary cytoreductive surgery and combination chemotherapy, ovarian cancer that has spread beyond the pelvis at the time of diagnosis can be cured in no more than 20% of cases. By contrast, when ovarian cancer is detected in Stage I, before it has spread from the ovaries, 90% of women can be cured with currently available therapy. At present, however, only 25% of ovarian cancers are diagnosed in Stage I (Ries et. al, 1999). Consequently, detection of preclinical disease at an earlier stage in a larger fraction of women might improve overall survival.

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  1. Departments of Experimental Therapeutics, Molecular Therapeutics, Gynecologic Oncology, Anatomic Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA

    Robert C. Bast Jr., Nicole Urban, Viji Shridhar, David Smith, Zhen Zhang, Steven Skates, Karen Lu, Jinsong Liu, David Fishman & Gordon Mills

  2. Departments of Experimental Therapeutics, Molecular Therapeutics, Gynecologic Oncology, Anatomic Pathology, The Fred Hutchinson Cancer Center, Seattle, WA, 98101, USA

    Robert C. Bast Jr., Nicole Urban, Viji Shridhar, David Smith, Zhen Zhang, Steven Skates, Karen Lu, Jinsong Liu, David Fishman & Gordon Mills

  3. Departments of Experimental Therapeutics, Molecular Therapeutics, Gynecologic Oncology, Anatomic Pathology, Mayo Clinic, Rochester, MN, 55905, USA

    Robert C. Bast Jr., Nicole Urban, Viji Shridhar, David Smith, Zhen Zhang, Steven Skates, Karen Lu, Jinsong Liu, David Fishman & Gordon Mills

  4. Departments of Experimental Therapeutics, Molecular Therapeutics, Gynecologic Oncology, Anatomic Pathology, Medical University of South Carolina, Charleston, SC, 29425, USA

    Robert C. Bast Jr., Nicole Urban, Viji Shridhar, David Smith, Zhen Zhang, Steven Skates, Karen Lu, Jinsong Liu, David Fishman & Gordon Mills

  5. Departments of Experimental Therapeutics, Molecular Therapeutics, Gynecologic Oncology, Anatomic Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA

    Robert C. Bast Jr., Nicole Urban, Viji Shridhar, David Smith, Zhen Zhang, Steven Skates, Karen Lu, Jinsong Liu, David Fishman & Gordon Mills

  6. Departments of Experimental Therapeutics, Molecular Therapeutics, Gynecologic Oncology, Anatomic Pathology, Northwestern University Medical School, Chicago, IL, 60611, USA

    Robert C. Bast Jr., Nicole Urban, Viji Shridhar, David Smith, Zhen Zhang, Steven Skates, Karen Lu, Jinsong Liu, David Fishman & Gordon Mills

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Bast, R.C. et al. (2002). Early Detection of Ovarian Cancer: Promise and Reality. In: Ovarian Cancer. Cancer Treatment and Research, vol 107. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3587-1_3

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