Abstract
Epidemiological studies from a variety of countries throughout the world have clearly established a relationship between smoking cigarettes and the development and/or progression of the atherosclerotic process (1). Although the epidemiologic evidence which correlates smoking and atherosclerosis is extensive, and thereby convincing, from a rigorous scientific point of view there are confounding variables in such studies which need further clarification. These confounding variables are life-style factors which predispose the individual to atherosclerotic disease in general (and coronary heart disease in particular), and are typified by sedentary living habits; obesity and/or unrestrained weight gain; a dietary intake which contains an excessive number of calories, fat, saturated fat, cholesterol, and salt; personal stress that is not modified; as well as cigarette smoking. It is not clear just how all of these risk factors interrelate among or between each other as variables in the pathogenesis of atherosclerosis. Analytical models which can unambiguously discriminate between such risk factors for a weighting of their contribution to the overall atherosclerotic process have yet to be developed.
Keywords
- Arterial Wall
- High Density Lipoprotein
- Atherosclerotic Process
- Mainstream Smoke
- High Density Lipoprotein Level
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
U.S. Office on Smoking and Health, “ The Health Consequences of Smoking: Cardiovascular Disease; a Report of the Surgeon General.” Washington, D.C., U.S. Government Printing Office, pp. 179–203, 1989.
Berg, Kare. Impact of medical genetics on research and practices in the area of cardiovascular disease. Clinical Genetics, 36: 299–312, 1989.
Ross, R. and A. Glomset. The pathogenesis of atherosclerosis. New Eng. J. Med. 295: 369–432, 1976.
Haust, M.D. Injury and repair in the pathogenesis of atherosclerotic lesions. In: Atherosclerosis, (R.J. Jones, Ed.) Springer-Verlag, New York, pp. 12–20, 1970.
Brown, M.S. and J.L. Goldstein. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Proc. Nat. Acad. Sci. USA 70: 1753–1756, 1983.
Carotid Artery Plaques: Pathogenesis, Development, Evaluation, Treatment (M. Hennerici, G. Sitzer, H-D Weger, Eds). Bertelsmann Foundation, S. Karger, Publishing Co., New York, N.Y. Basel, 1988.
Chemistry and Analysis of Tobacco Smoke. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Tobacco Smoking. International Agency for Research on Cancer, Publisher, Vol. 38: 83–126, 1986.
Brischetto, C.S., W.B. Connor, S.L. Connor, and J.D. Matarazzo. Plasma lipid and lipoprotein profiles of cigarette smokers from randomly selected families: enhancement of hyperlipidemia and depression of high density lipoprotein. Am. J. Cardiol. 62: 675–681, 1983.
Barrett, T.B. and E.P. Benditt. Platelet-derived growth factor gene expression in human atherosclerotic plaques and normal artery wall. Proc. Natl. Acad. Sci. 85: 2810–2814, 1988.
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© 1990 Plenum Press, New York
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Diana, J.N. (1990). Tobacco Smoking and Atherosclerosis: Overview. In: Diana, J.N. (eds) Tobacco Smoking and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 273. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5829-9_1
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DOI: https://doi.org/10.1007/978-1-4684-5829-9_1
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