CD4 as the Receptor for Retroviruses of the HTLV Family: Immunopathogenetic Implications

  • M. Carbonari
  • M. Fiorilli
  • I. Mezzaroma
  • M. Cherchi
  • F. Aiuti
Conference paper

DOI: 10.1007/978-1-4684-5712-4_2

Volume 257 of the book series Advances in Experimental Medicine and Biology (AEMB)
Cite this paper as:
Carbonari M., Fiorilli M., Mezzaroma I., Cherchi M., Aiuti F. (1989) CD4 as the Receptor for Retroviruses of the HTLV Family: Immunopathogenetic Implications. In: Askonas B.A., Moss B., Torrigiani G., Gorini S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA

Abstract

CD4 is the HIV (Human immunodeficiency virus type I) receptor, and the virus seems to bind to it through the Leu3a/0KT4a epitope (Klatzmann et al., 1985), HIV infection may lead to the destruction of CD4+ cells both by direct and indirect mechanisms. Direct mechanisms include the formation of syncitia among infected cells (Lifson et al., 1936). Indirect mechanisms may involve autoimmune reactions, of both cell mediated and humoral types (Klatzmann and Montagnier, 1986).

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • M. Carbonari
    • 1
  • M. Fiorilli
    • 1
  • I. Mezzaroma
    • 1
  • M. Cherchi
    • 1
  • F. Aiuti
    • 1
  1. 1.Department of Allergy and Clinical ImmunologyUniversity of Rome “La Sapienza”RomeItaly