Chapter

The Immune Response to Viral Infections

Volume 257 of the series Advances in Experimental Medicine and Biology pp 3-7

CD4 as the Receptor for Retroviruses of the HTLV Family: Immunopathogenetic Implications

  • M. CarbonariAffiliated withDepartment of Allergy and Clinical Immunology, University of Rome “La Sapienza”
  • , M. FiorilliAffiliated withDepartment of Allergy and Clinical Immunology, University of Rome “La Sapienza”
  • , I. MezzaromaAffiliated withDepartment of Allergy and Clinical Immunology, University of Rome “La Sapienza”
  • , M. CherchiAffiliated withDepartment of Allergy and Clinical Immunology, University of Rome “La Sapienza”
  • , F. AiutiAffiliated withDepartment of Allergy and Clinical Immunology, University of Rome “La Sapienza”

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Abstract

CD4 is the HIV (Human immunodeficiency virus type I) receptor, and the virus seems to bind to it through the Leu3a/0KT4a epitope (Klatzmann et al., 1985), HIV infection may lead to the destruction of CD4+ cells both by direct and indirect mechanisms. Direct mechanisms include the formation of syncitia among infected cells (Lifson et al., 1936). Indirect mechanisms may involve autoimmune reactions, of both cell mediated and humoral types (Klatzmann and Montagnier, 1986).