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Steroid Receptors in Health and Disease pp 177–186Cite as

The Mammalian Progesterone Receptor: Cloning, Immunolocalization and Mechanism of Interaction with DNA

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Abstract

Steroid hormone receptors have two essential functions: hormone binding, then DNA binding and transcription modulation. Although these two properties have been thoroughly characterized (review in 1), their structural basis has been only recently unraveled. The obtention of monoclonal antibodies against purified receptor and the subsequent cloning of receptor cDNA has been the key to the recent progress in the case of the progesterone receptor (2) as well as other steroid receptors (3–5).

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Authors and Affiliations

  1. Hormones et Reproduction (INSERM U. 135), Faculte de Medecine Paris-Sud, 94275, Le Kremlin-Bicetre Cedex, France

    Jean-Francois Savouret, Hugues Loosfelt, Micheline Misrahi, Michel Atger, Alain Bailly, Martine Perrot-Applanat, Anne Guiochon-Mantel, Michel Rauch & Edwin Milgrom

Authors
  1. Jean-Francois Savouret
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  2. Hugues Loosfelt
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  3. Micheline Misrahi
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  4. Michel Atger
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  5. Alain Bailly
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  6. Martine Perrot-Applanat
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  7. Anne Guiochon-Mantel
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  8. Michel Rauch
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  9. Edwin Milgrom
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Editors and Affiliations

  1. Oakland University, Rochester, Michigan, USA

    Virinder K. Moudgil (Chairman) (Chairman)

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© 1988 Plenum Press, New York

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Savouret, JF. et al. (1988). The Mammalian Progesterone Receptor: Cloning, Immunolocalization and Mechanism of Interaction with DNA. In: Moudgil, V.K. (eds) Steroid Receptors in Health and Disease. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5541-0_13

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  • DOI: https://doi.org/10.1007/978-1-4684-5541-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5543-4

  • Online ISBN: 978-1-4684-5541-0

  • eBook Packages: Springer Book Archive

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