Abstract
Somatostatin, like many other peptide systems, is a multigene family with two principal bioactive forms corresponding to somatostatin-14 (S-14) and somatostatin-28 (S-28) (1).
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References
Patel YC, Zingg HH, Srikant CB. Somatostatin-14 like immunoreactive forms in the rat: characterization, distribution and biosynthesis. In: Patel YC, Tannenbaum GS, eds. Somatostatin. New York: Plenum Press, 1985.
Dixon JE, Andrews PC. Somatostatins of the channel catfish. In: Patel YC, Tannenbaum GS, eds. Somatostatin. New York: Plenum Press, 1985.
Spiess J, Noe BD. Processing of an anglerfish somatostatin precursor to a hydroxylysine containing somatostatin-28. Proc Natl Acad Sci USA 1985; 82: 277.
Hobart P, Crawford R, Shen LP, Raymond P, Rutter WJ. Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish. Nature 1980; 288: 137.
Noe BD, Debo G, Spiess J. Comparison of prohormone-processing activities in islet microsomes and secretory granules: evidence for distinct converting enzymes for separate islet prosomatostatins. J Cell Biol 1984; 99: 578.
Montminy MR, Goodman RH, Horovitch SJ, Habener JF. Primary structure of the gene encoding rat preprosomatostatin. Proc Natl Acad Sci USA 1984; 81: 3337.
Tavianini MA, Hayes TE, Magazin MD, Minth CD, Dixon JE. Isolation, characterization, and DNA sequence of the rat somatostatin gene. J Biol Chem 1984; 259: 1 1798.
Ravazzola M, Benoit R, Ling N, Guillemin R, Orci L. Immunocytochemical localization of prosomatostatin fragments in maturing and mature secretory granules of pancreatic and gastrointestinal D cells. Proc Natl Acad Sci USA 1983; 80: 215.
Reichlin S. Somatostatin. N Engl J Med 1983; 309: 1495.
Brown MR, Rivier C, Vale W. Central nervous system regulation of adrenocorticotropin secretion: role of somatostatins. Endocrinology 1984; 114: 1546.
Brazeau P, Ling N, Esch F, Bohlen P, Benoit R, Guillemin R. High biological activity of the synthetic replicates of somatostatin-28 and somatostatin-25. Regul Pept 1981; 1: 255.
Klaff LJ, Barron JL, Levitt NS, Ling N, Millar RP. Somatostatin-28 inhibits thyroid-stimulating hormone release in man. S Afr Med J 1982; 62: 929.
Konturek SJ, Tasler J, Jaworek J, et al. Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin. Proc Natl Acad Sci USA 1981; 78: 1967.
Mandarino L, Stenner D, Blanchard W, et al. Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion. Nature 1981; 291: 76.
Seal A, Yamada T, Debas H, et al. Somatostatin-14 and -28: clearance and potency on gastric function in dogs. Am J Physiol 1982; 243: G97.
Susini C, Esteve JP, Vaysse N, Pradayrol L, Ribet A. Somatostatin28: effects on exocrine pancreatic secretion in conscious dogs. Gastroenterology 1979; 79: 720.
Srikant CB, Patel YC. Somatostatin receptors. In: Patel YC, Tannenbaum GS, eds. Somatostatin. New York: Plenum Press, 1985.
Schonbrunn A, Tashjian A Jr. Characterization of functional receptors for somatostatin in rat pituitary cells in culture. J Biol Chem 1978; 253: 6473.
Srikant CB, Patel YC. Identification and characterization of Somatostatin receptors in rat brain synaptosomal membranes. Proc Natl Acad Sci USA 1981; 78: 3930.
Srikant CB, Patel YC. Characterization of pituitary membrane receptors for somatostatin in the rat. Endocrinology 1982; 110: 2138.
Aguilera G, Parker DS, Catt KJ. Characterization of somatostatin receptors in the rat adrenal glomerulosa zone. Endocrinology 1982; 111: 1376.
Reubi J-C, Perrin M, Rivier J, Vale W. High affinity binding sites for somatostatin to rat pituitary. Biochem Biophys Res Commun 1982; 105: 1538.
Enjalbert A, Tapia-Arancibia L, Rieutort M, Brazeau P, Kordon C, Epelbaum J. Somatostatin receptors in rat anterior pituitary membranes. Endocrinology 1982; 110: 1634.
Aguilera G, Parker DS. Pituitary somatostatin receptors: characterization by binding with a non-degradable peptide analogue. J Biol Chem 1982; 257: 1134.
Srikant CB, Patel YC. Somatostatin receptors in rat adrenal cortex: characterization and comparison with brain and pituitary receptors. Endocrinology 1985; 116: 1717.
Srikant CB, Patel YC. Somatostatin receptors on rat pancreatic acinar cells: pharmacological and structural characterization and demonstration of down-regulation in streptozotocin diabetes. J Biol Chem 1986; 261: 7690.
Esteve JP, Susini C, Vaysse N, et al. Binding of somatostatin to pancreatic acinar cells. Am J Physiol 1984; 247: G62.
Sakamoto C, Goldfine ID, Williams JA. The somatostatin receptor on isolated pancreatic acinar cell plasma membranes: identification of subunit structure and direct regulation by cholecystokinin. J Biol Chem 1984; 259: 9623.
Beal MF, Tran VT, Mazurek MF, Chaltha G, Martin JB. Somatostatin binding sites in human and monkey brain: localization and characterization. J Neurochem 1986; 46: 359.
Richardson UI, Schonbrunn A. Inhibition of adrenocorticotropin secretion by somatostatin in pituitary cells in culture. Endocrinology 1981; 108: 281.
Srikant CB, Heisler S. Relationship between receptor binding and biopotency of somatostatin-14 and somatostatin-28 in mouse pituitary tumor cells. Endocrinology 1985; 117: 271.
Bhathena SJ, Oie HK, Gazdar AF, Voyler NR, Wilkins SD, Recant L. Insulin, glucagon and somatostatin receptors in cultured cells and clones from rat islet cell tumor. Diabetes 1982; 31: 521.
Reubi J-C, Rivier J, Perrin M, Brown M, Vale W. Specific high affinity binding sites for somatostatin-28 on pancreatic B-cells: differences with brain somatostatin receptors. Endocrinology 1982; 110: 1049.
Reubi J-C, Landolt AM. High density of somatostatin receptors in pituitary tumors from acromegalic patients. J Clin Endocrinol Metab 1984; 59: 1148.
Moyse E, Le Dafniet M, Epelbaum J, et al. Somatostatin receptors in human growth hormone and prolactin-secreting pituitary adenomas. J Clin Endocrinol Metab 1985; 61: 98.
Reubi J-C, Maurer R, Klijin JGM, et al. High incidence of somatostatin receptors in human meningioma: biochemical characterization. J Clin Endocrinol Metab 1986; 63: 433.
Elde R, Johansson 0, Hokfelt T. Immunocytochemical studies of somatostatin neurons in brain. In: Patel YC, Tannenbaum GS, eds. Somatostatin. New York: Plenum Press, 1985.
Morel G, Mesguich P, Dubois MP, Dubois PM. Ultrastructural autoradiographic localization of somatostatin-28 in the rat pituitary gland. Endocrinology 1985; 116: 1615.
Patel YC, Baquiran G, Srikant CB, Peer BI11 Quantitative in vivo auto§adiograpc h§alizaHon of [I-Tyr] somatostatin-14 and [Leu, D-Trp, I-Tyr] somatostatin-28 binding sites in rat brain. Endocrinology 1986; 119: 2262.
Maurer R, Reubi J-C. Distribution and coregulation of three peptide receptors in adrenals. Eur J Pharmacol 1986; 125: 241.
Patel YC, Amherdt M, Orci L. Quantitative electron microscopic radiography of insulin, glucagon and somatostatin binding sites on islets. Science 1982; 217: 1155.
Draznin B, Leitner JW, Sussman KE. Kinetics of somatostatin receptor migration in isolated pancreatic islets. Diabetes 1982; 31: 467.
Reyl FJ, Lewin MJM. Intracellular receptor for somatostatin in gastric mucosal cells: decomposition and reconstitution of somatostatin-stimulated phosphoprotein phosphate. Proc Natl Acad Sci USA 1982; 79: 978.
Reyl FJ, Lewin MJM. Evidence for an intracellular somatostatin receptor in pancreas: a comparative study with reference to gastric mucosa. Biochem Biophys Res Commun 1982; 109: 1324.
Arilla E, Lopez-Ruiz MP, Guijarro LG, Prieto JC, Gomez-Pan A, Hirst B. Characterization of somatostatin binding sites in cytosolic fraction of rat intestinal mucosa. Biochem Biophys Acta 1984; 802: 203.
Guijarro LG, Arilla E, Lopez-Ruiz MP, Prieto JC, Whitford C, Hirst BH. Somatostatin binding sites in cytosolic fraction isolated from rabbit antral and fundic gastric mucosa. Regul Pept 1985; 10: 207.
Arilla E, Colas B, Prieto JC. Specific somatostatin-binding to cytosol of bovine gallbladder mucosa. Biosci Rep 1986; 6: 283.
Srikant CB, Patel YC. Somatostatin analogs: dissociation of brain receptor binding affinities and pituitary actions in the rat. Endocrinology 1981; 108: 341.
Reubi J-C. Evidence for two somatostatin-14 receptor types in rat brain cortex. Neurosci Lett 1984; 49: 259.
Tran V, Beal MF, Martin JB. Two types of somatostatin receptors differentiated by cyclic somatostatin analogs. Science 1985; 228: 492.
Reubi J-C. Novel selective radioligand for one population of rat cortex somatostatin receptors. Life Sci 1985; 36: 1829.
Reubi J-C, Maurer R. Different ionic requirements for somatostatin receptor subpopulations in the brain. Regul Pept 1986; 14: 301.
Srikant CB, Patel YC. Chemical cross-linking of somatostatin receptors in rat adrenal cortex. Biochem Biophys Res Commun 1986; 139: 757.
Srikant CB, Patel YC. Cysteamine-induced depletion of brain somatostatin is associated with up-regulation of cerebrocortical somatostatin receptors. Endocrinology 1984; 115: 990.
Srikant CB, Patel YC. Receptor binding of somatostatin-28 is tissue specific. Nature 1981; 294: 259.
Schonbrunn A, Rorstad OP, Westendrog JM, Martin JM. Somatostatin analogs: correlation between receptor binding affinity and biological potency in GH pituitary cells. Endocrinology 1983; 113: 1559.
Reubi J-C, Rivier J, Perrin M, Brown M, Vale W. High affinity binding sites for a somatostatin-28 analog in rat brain. Life Sci 1981; 28: 2191.
Rodbell M, Krans HM, Pohl SL, Birnhaumer L. The glucagon-sensitive adenylcyclase system in plasma meanes of rat liver: effects of guanyl nucleotides on binding of I-glucagon. J Biol Chem 1971; 246: 1872.
Kent RS, De Lean A, Lefkowitz RJ. A quantitative analysis of betaadrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modelling of ligand binding data. Mol Pharmacol 1980; 17: 14.
Smith KE, Floss WP. Guanine nucleotides regulate 3H-substance P binding in rat small intestine. Regul Pept 1985; 11: 275.
Dahan A, Srikan LLB. iifferential effe is of anii and adenine nucleotides on ~2’I-T ~I g ~g 25[y] S-14 and [Leu, D-Trp, I-Tyr] S-28 binding sites in rat brain [Abstract]. International Conference on Somatostatin, Washington, DC, 1986.
Enjalbert A, Rasolonjanahary R, Moyy E, Kordon C, Epelbaum J. Guanine nucleotide sensitivity of [I] iodo N-Tyr somatostatin binding in rat adenohypophysis and cerebral cortex. Endocrinology 1983; 113: 822.
Koch BD, Schonbrunn A. The somatostatin receptor is directly coupled to adenylate cyclase in GH4C1 pituitary cell membranes. Endocrinology 1984; 114: 1784.
Koch BD, Dorflinger LJ, Schonbrunn A. Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. J Biol Chem 1985; 260: 13138.
Susini C, Esteve JP, Vaysse N, Ribet A. Calcium-dependence of somatostatin binding to receptors. Peptides 1985; 6: 831.
Leroux P, Quirion R, Pelletier G. Localization and characterization of brain somatostatin receptors studied with somatostatin-14 and somatostatin-28 receptor radioautography. Brain Res 1985; 347: 74.
Amherdt M, Patel YC, Orci L. Selective binding of somatostatin-14 and somatostatin-28 to islet cells revealed by quantitative electron microscopic autoradiography. Science 1986 (submitted).
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Srikant, C.B., Patel, Y.C. (1987). Somatostatin Receptor: Evidence for Functional and Structural Heterogeneity. In: Reichlin, S. (eds) Somatostatin. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5326-3_9
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DOI: https://doi.org/10.1007/978-1-4684-5326-3_9
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