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Fusion of Cytoplasts and Karyoplasts and How This Pertains to Research of Aging and Transformation

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Book cover Senescence

Part of the book series: Cellular Senescence and Somatic Cell Genetics ((CSSCG,volume 2))

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Abstract

Before describing a method for fusion of isolated karyoplasts and cytoplasts of the human diploid cell WI-38, I would like to review some of the previous techniques and research involving cell hybridization and nuclear transfer. After this introduction I will suggest ways in which I feel the technique which I have developed in the laboratory of Dr. L. Hayflick at Stanford University can overcome many of the drawbacks found with the earlier techniques, as well as ways in which this particular approach can be utilized to study aging and malignancy.

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References

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Author information

Authors and Affiliations

  1. Department of Medical Microbiology, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Audrey L. Muggleton-Harris

Authors
  1. Audrey L. Muggleton-Harris
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Editor information

Editors and Affiliations

  1. Institute for Medical Research, Camden, New Jersey, USA

    Warren W. Nichols

  2. National Institute on Aging, Bethesda, Maryland, USA

    Donald G. Murphy

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© 1977 Plenum Press, New York

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Muggleton-Harris, A.L. (1977). Fusion of Cytoplasts and Karyoplasts and How This Pertains to Research of Aging and Transformation. In: Nichols, W.W., Murphy, D.G. (eds) Senescence. Cellular Senescence and Somatic Cell Genetics, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2508-6_5

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  • DOI: https://doi.org/10.1007/978-1-4684-2508-6_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2510-9

  • Online ISBN: 978-1-4684-2508-6

  • eBook Packages: Springer Book Archive

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