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Abnormal Organogenesis in the Cardiovascular System

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Abstract

The relative importance of genetic and environmental factors in cardiovascular development has been long debated (cf. Goerttler, 1958, 1970). In a review of the experimental production of cardiovascular defects, Wilson (1960) stressed the importance of nongenetic hemodynamic factors. Analyses of the etiology of congenital heart disease (Nora, 1968; Nora et al., 1970; Neill, 1972) have shown that a clearly defined genetic etiology is demonstrable in only a small proportion of the victims (<5%); these analyses were interpreted in terms of a multifactorial theory, which assumes that environmental stresses produced congenital heart disease to the greatest extent in those individuals most predisposed genetically.

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Author information

Authors and Affiliations

  1. Department of Biology, University of Dayton, Dayton, Ohio, 45469, USA

    Oscar C. Jaffee

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  1. Oscar C. Jaffee
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Editors and Affiliations

  1. The Children’s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA

    James G. Wilson

  2. Departments of Biology and Paediatrics, McGill University and The Montreal Children’s Hospital, Montreal, Canada

    F. Clarke Fraser

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© 1977 Plenum Press, New York

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Jaffee, O.C. (1977). Abnormal Organogenesis in the Cardiovascular System. In: Wilson, J.G., Fraser, F.C. (eds) Handbook of Teratology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8933-4_14

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  • DOI: https://doi.org/10.1007/978-1-4615-8933-4_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8935-8

  • Online ISBN: 978-1-4615-8933-4

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