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Sex Steroids and Endothelin

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Book cover Endocrinology of Cardiovascular Function

Part of the book series: Endocrine Updates ((ENDO,volume 1))

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Abstract

Cardiovascular mortality is the major cause of death in both men and women in the United States. However, epidemiological studies have shown that the prevalence cf cardiovascular disease is significantly less in premenopausal women than inagematched men. There is an approximate 10 year time lag in the development of coronary artery disease in premenopausal women compared to men, however, this gap appears to narrow after the menopause (1, 2). Such data would suggest that E, when produced at much higher levels during the reproductive years has a cardioprotective effect in women (3). Numerous studies have suggested that estrogen (E) replacement therapy reduces morbidity and mortality in postmenopausal women, largely by preventing the development of coronary artery disease (4). However, a paucity of data precludes conclusions about the effects of progesterone (P).

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  1. Anjali K. Morey Ph.D
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  2. Ellis R. Levin M.D.
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Editors and Affiliations

  1. DVA Medical Center and University of California, Irvine, USA

    Ellis R. Levin M.D.

  2. City of Hope Medical Center, Duarte, California, USA

    Jerry L. Nadler M.D.

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Morey, A.K., Levin, E.R. (1998). Sex Steroids and Endothelin. In: Levin, E.R., Nadler, J.L. (eds) Endocrinology of Cardiovascular Function. Endocrine Updates, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5569-8_2

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