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New Cytokines and their Clinical Application

  • Chapter
Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 101))

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Abstract

The production of mature blood cells is controlled by a network of proteins called hematopoietic growth factors (HGFs). A number of HGFs were identified by their ability to stimulate colony formation in semi solid agar culture of normal bone marrow (1-2), and were called colony stimulating factors (3). It was shown that colonies of mature granulocytes were formed in the presence of granulocyte colony stimulating factor (G-CSF) (4), colonies of mature macrophages were formed in the presence of macrophage colony stimulating factor (M-CSF or CSF-1) (5) and mixed colonies of macrophages and granulocytes were formed in the presence of granulocyte-macrophage colony stimulating factor (GM-CSF) (6). Subsequently, some of the CSFs have been taken to clinical trials and are now used routinely in clinical treatments. G-CSF for example has been shown to stimulate recovery of neutrophils after chemotherapy and is used clinically to shorten the period of neutropenia after chemotherapy (7,8). Both G-CSF and GM-CSF are routinely used alone or in combination with chemotherapy to mobilize peripheral blood progenitor cells (PBPC) from the bone marrow to the peripheral circulation (9,10). The use of PBPC has replaced the use of bone marrow for cellular support following high dose chemotherapy, due to more rapid recovery in neutrophils and platelets resulting in a considerable decrease in overall costs of the transplant (11).

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  1. Bone Marrow Transplant Unit, University of Colorado Health Sciences Center, Denver, 80262, CO, USA

    Ian K. McNiece Ph.D

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  1. Northwestern University Medical Center, Chicago, USA

    Richard K. Burt  & Mary M. Brush  & 

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McNiece, I.K. (1999). New Cytokines and their Clinical Application. In: Burt, R.K., Brush, M.M. (eds) Advances in Allogeneic Hematopoietic Stem Cell Transplantation. Cancer Treatment and Research, vol 101. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4987-1_18

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