Cytokine Induced Regulation of 15-Lipoxygenase and Phospholipid Hydroperoxide Glutathione Peroxidase in Mammalian Cells

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Abstract

Lipid peroxidation has been implicated in the pathogenesis of various diseases such as cancer, atherosclerosis, and neurodegenarative disorders (Louvel et al., 1997). Under resting conditions the intracellular peroxide level of mammalian cells is rather low (Weitzel and Wendel, 1993) and this may be due to the high reducing capacity of most mammalian cells. However, during cell activation the cellular peroxide tone may be increased leading to membrane damage and even cell death. The cellular peroxide tone is a steady state concentration which depends inter alia on the expression of pro- and anti-oxidative enzymes. With respect to lipid peroxidation 15-lipoxygenases (15-LO’s) and the phospholipid hydroperoxide glutathione peroxidase (PH-GPx) constitute opposite enzymes in the cellular metabolism of hydroperoxy ester lipids.