Post-transcriptional and post-translational modifications
Purchase on Springer.com
$29.95 / €24.95 / £19.95*
* Final gross prices may vary according to local VAT.
Transcription and translation are regarded as the central events in gene expression. However, they are rarely sufficient on their own to result in the synthesis of a functional protein. Two important additional processes are needed. The first is mRNA processing orpost-transcriptional modification. It occurs between transcription and translation in eukaryotes, but does not occur in bacteria. The process involves a series of modifications that the RNA transcript (hnRNA) must undergo before it can be translated (Fig. 5.1). The second process is protein processing orpost-translational modification. This second type of modification occurs in all organisms and converts the polypeptide synthesized by translation into a functional protein.
- Darnell, J.E., Philipson, L., Wall, R., and Adesnik, M. (1971) Polyadenylic acid sequences: role in the conversion of nuclear RNA into messenger RNA. Science 174, 507–10. One of the first papers to connect the poly(A) found in the hnRNA with that in the mRNA. CrossRef
- Humphrey, T. and Proudfoot, N. J., (1988) A begining to the biochemistry of polyadenylation. Trends in Genetics 4, 243–4. An update on possible roles for the poly(A) sequence. CrossRef
- Chambon, P. (1981) Split genes. Scientific American 244(11), 48–59 is a review describing the discovery of discontinuous genes and a description of the splicing pathway for the chicken ovalbumin pre-mRNA.
- Sharp, P. A. (1987) Splicing of messenger RNA precursors. Science 235, 766–71, CrossRef
- and Padgett, R. A. et al. (1985) Splicing messenger RNA precursors: branch sites and lariat RNAs. Trends in Biochemical Sciences 10, 154–7. Two scholarly reviews describing how splicing occurs. CrossRef
- Wold, F. (1981) In vivo chemical modification of proteins (post-translational modification). Annual Review of Biochemistry 50, 783–814. A comprehensive description of various chemical modifications of amino acid residues. CrossRef
- Carraway, K.L. and Hall, S.R. (1989) O-Glycosylation pathway for mucin-type glycoproteins. BioEssays 10, 117–21. Excellent essay giving an overview of the synthesis of O-linked glycans. CrossRef
- Kornfeld, R. and Kornfeld, S. (1985) Assembly of asparagine-linked oligosaccharides. Annual Review of Biochemistry 45, 631–64. A full description of the biosynthesis of N-linked oligosaccharides. CrossRef
- Cole, C.R. and Smith, C.A. (1989) Glycoprotein biochemistry (structure and function). Biochemical Education 17, 179–89. CrossRef
- Cole, C.R. and Smith, C.A. (1990) Glycoprotein biochemistry (biosynthesis). Biochemical Education, 18, 110–22. Two recent reviews on the biochemistry and molecular biology of glycoproteins. CrossRef
- Towler, D.A. et al. (1988) The biology and enzymology of eukaryotic protein acylation. Annual Review of Biochemistry 57, 69–99. This is currently the best description of protein acylation. CrossRef
- Steiner, D.F. et al. (1980) Processing mechanisms in the biosynthesis of proteins. Annals of the New York Academy of Sciences 343, 1–16. Gives a good general overview of proteolytic processing of proteins. CrossRef
- Neurath, H. (1986) The versatility of proteolytic enzymes. Journal of Cellular Biochemistry 32, 35–49. An introductory review on the role of proteolytic processing as a post-translational modification. CrossRef
- Post-transcriptional and post-translational modifications
- Book Title
- Molecular Biology and Biotechnology
- pp 88-111
- Print ISBN
- Online ISBN
- Springer US
- Copyright Holder
- Chapman & Hall Limited
- Additional Links
- eBook Packages
To view the rest of this content please follow the download PDF link above.