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Genes, Oncogenes, and Hormones pp 413–431Cite as

Stromal-epithelial interactions in breast cancer

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 61))

Abstract

Breast malignancies are almost exclusively epithelial cancers. Epithelial cells that have undergone malignant transformation arise from ductal or lobular elements within the breast parenchyma. However, no breast cancer can grow beyond the microscopic level simply as a proliferation of malignant epithelium. Clinically significant breast tumors are a complex and heterogeneous mix of epithelium, stromal cells, matrix proteins, and vascular elements. The growth and dissemination of a breast cancer requires complex but poorly understood interactions between these various tumor elements. To grow beyond the microscopic level, a tumor must acquire a blood supply. To acquire invasive or metastatic potential, a tumor must be able to manipulate and degrade surrounding basement membrane and intercellular matrix to escape into lymphatic or vascular channels. These same properties may be necessary for a metastatic tumor focus to develop at a distance from the primary tumor.

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Authors
  1. Kevin J. Cullen
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  2. Marc E. Lippman
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Editors and Affiliations

  1. Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington, D.C., USA

    Robert B. Dickson  & Marc E. Lippman  & 

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Cullen, K.J., Lippman, M.E. (1991). Stromal-epithelial interactions in breast cancer. In: Dickson, R.B., Lippman, M.E. (eds) Genes, Oncogenes, and Hormones. Cancer Treatment and Research, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3500-3_20

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