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Intermediate filament protein expression in normal and malignant human mammary epithelial cells

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Book cover Genes, Oncogenes, and Hormones

Part of the book series: Cancer Treatment and Research ((CTAR,volume 61))

Abstract

The proteins that make up the intermediate filaments of mammalian cells have in the last 10 years or so been defined in detail at the biochemical and structural level, while the profile of expression of these proteins has been monitored in a wide variety of cells and tissues. The various classes of intermediate filament proteins (IFPs), listed in Table 1, show considerable structural similarities but are antigenically distinguishable, so that monoclonal antibodies can be developed that exclusively recognize a single species. In studying the expression of IFPs at the cellular level, particularly in complex tissues, it is these monospecific antibodies that have proved to be extremely useful.

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Authors
  1. J. Taylor-Papadimitriou
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  2. R. Wetzels
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  3. F. Ramaekers
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Editors and Affiliations

  1. Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington, D.C., USA

    Robert B. Dickson  & Marc E. Lippman  & 

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© 1991 Springer Science+Business Media New York

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Taylor-Papadimitriou, J., Wetzels, R., Ramaekers, F. (1991). Intermediate filament protein expression in normal and malignant human mammary epithelial cells. In: Dickson, R.B., Lippman, M.E. (eds) Genes, Oncogenes, and Hormones. Cancer Treatment and Research, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3500-3_17

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  • DOI: https://doi.org/10.1007/978-1-4615-3500-3_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6552-5

  • Online ISBN: 978-1-4615-3500-3

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