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Treatment of gallbladder cancer

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Book cover Hepatobiliary Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 69))

Abstract

Although an uncommon malignancy, carcinoma of the gallbladder is the fifth most common cancer of the gastrointestinal tract and the most common cancer of the biliary tract [1]. The diagnosis of gallbladder carcinoma is made incidentally at the time of exploration in 1% of patients undergoing surgical treatment for cholelithiasis [1,2]. Carcinoma of the gallbladder is more common in females, three fourths of the patients being women with a median age in the seventh decade. In most patients, the disease is advanced and unresectable. The overall prognosis, therefore, is rather dismal, with 5year survival rates of less than 5% reported in most large published series [1–27]. However, in a small group of early lesions, surgery provides a reasonable probability of long-term survival. Radiation and chemotherapy have mostly a palliative role in the treatment of gallbladder carcinoma, and the experience with these treatment modalities is derived from their use in a rather limited number of patients.

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References

  1. Piehler JM, Crichlow RW. 1978. Primary carcinoma of the gallbladder. Surg Gynecol Obstet 147:929–942.

    PubMed  CAS  Google Scholar 

  2. Hamrick RE, Liner J, Hastings PR, et al. 1982. Primary carcinoma of the gallbladder. Ann Surg 195:270–273.

    Article  PubMed  Google Scholar 

  3. Adson MA. 1973. Carcinoma of the gallbladder. Surg Clin North Am 53:1203–1216.

    PubMed  CAS  Google Scholar 

  4. Beltz WR, Condon RE. 1974. Primary carcinoma of the gallbladder. Ann Surg 180: 180–184.

    Article  PubMed  CAS  Google Scholar 

  5. Bossart PA, Patterson AH, Zintel HA. 1962. Carcinoma of the gallbladder: A report of seventy-six cases. Am J Surg 103:366–369.

    Article  PubMed  CAS  Google Scholar 

  6. Chandler JJ, Fletcher WS. 1963. A clinical study of primary carcinoma of the gallbladder. Surg Gynecol Obstet 117:297–300.

    PubMed  CAS  Google Scholar 

  7. Donaldson LA, Busuttil A. 1975. A clinicopathological review of 68 carcinomas of the gallbladder. Br J Surg 62:26–32.

    Article  PubMed  CAS  Google Scholar 

  8. Keill RH, DeWeese MS. 1973. Primary carcinoma of the gallbladder. Am J Surg 125: 726–729.

    Article  PubMed  CAS  Google Scholar 

  9. Litwin MS. 1967. Primary carcinoma of the gallbladder: A review of 78 patients. Arch Surg 95:236–240.

    Article  PubMed  CAS  Google Scholar 

  10. Moossa AR, Anagnost M, Hall AW, et al. 1975. The continuing challenge of gallbladder cancer: Survey of thirty years’ experience at the University of Chicago. Am J Surg 130:57–62.

    Article  PubMed  CAS  Google Scholar 

  11. Nevin JE, Moran TJ, Kay S, et al. 1976. Carcinoma of the gallbladder. Cancer 37:141–148.

    Article  PubMed  CAS  Google Scholar 

  12. Robertson WA, Carlisle BB. 1967. Primary carcinoma of the gallbladder: Review of fifty-two cases. Am J Surg 113:738–742.

    Article  PubMed  CAS  Google Scholar 

  13. Thorbjarnarson B, Glenn F. 1959. Carcinoma of the gallbladder. Cancer 12:1009–1015.

    Article  PubMed  CAS  Google Scholar 

  14. Vaittinen E. 1970. Carcinoma of the gallbladder: A study of 390 cases diagnosed in Finland 1953–1967. Ann Chir Gynaecol (Suppl) 168:7–81.

    Google Scholar 

  15. Wanebo HJ, Castle WN, Fechner RE. 1982. Is carcinoma of the gallbladder a curable lesion? Ann Surg 195:624–631.

    Article  PubMed  CAS  Google Scholar 

  16. Barr LH, Wright FH. 1984. Carcinoma of the gallbladder. Am Surg 50:275–276.

    PubMed  CAS  Google Scholar 

  17. Morrow CE, Sutherland DE, Florack G, et al. 1983. Primary gallbladder carcinoma: Significance of subserosal lesions and results of aggressive surgical treatment and adjuvant chemotherapy. Surgery 94:709–714.

    PubMed  CAS  Google Scholar 

  18. Friedman RB, Anderson RE, Gilchrist KW, et al. 1983. Prognostic factors in invasive gallbladder carcinoma. J Surg Oncol 23:189–194.

    Article  PubMed  CAS  Google Scholar 

  19. Klamer TW, Max MH. 1983. Carcinoma of the gallbladder. Surg Gynecol Obstet 156: 641–645.

    PubMed  CAS  Google Scholar 

  20. Dunbar LL, Adkins RB, Farringer J, et al. 1983. Carcinoma of the gallbladder and bile ducts: A retrospective review. Am Surg 49:94–104.

    PubMed  CAS  Google Scholar 

  21. Nagashima H, Watanabe A, Hayashi S, et al. 1982. Primary carcinoma of the gallbladder and the extrahepatic bile duct. Gastroenterology 17:246–253.

    CAS  Google Scholar 

  22. Tashiro S, Konno T, Mochinaga M, et al. 1982. Treatment of carcinoma of the gallbladder in Japan. Jpn J Surg 12:98–104.

    Article  PubMed  CAS  Google Scholar 

  23. Albores-Saavedra J, Cruz-Ortiz H, Alcantra-Vazquez A, et al. 1981. Unusual types of gallbladder carcinoma: A report of 16 cases. Arch Pathol Lab Med 105:287–293.

    PubMed  CAS  Google Scholar 

  24. Koo J, Wong J, Cheng FC, et al. 1981. Carcinoma of the gallbladder. Br J Surg 68: 161–165.

    Article  PubMed  CAS  Google Scholar 

  25. Evander A, Ihse I. 1981. Evaluation of intended radical surgery in carcinoma of the gallbladder. Br J Surg 68:158–160.

    Article  PubMed  CAS  Google Scholar 

  26. Gupta S, Udupa KN, Gupta S. 1980. Primary carcinoma of the gallbladder: A review of 328 cases. J Surg Oncol 14:35–44.

    Article  PubMed  CAS  Google Scholar 

  27. Bergdahl L. 1980. Gallbladder carcinoma first diagnosed at microscopic examination of gallbladder removed for presumed benign disease. Ann Surg 191:19–22.

    Article  PubMed  CAS  Google Scholar 

  28. Gall FP, Kockerling F, Scheele J, et al. 1991. Radical operations for carcinoma of the gallbladder: Present status in Germany. World J Surg 15:328–336.

    Article  PubMed  CAS  Google Scholar 

  29. Tashiro S, Konno T, Mochinaga M, et al. 1982. Treatment of carcinoma of the gallbladder in Japan. Jpn J Surg 12:98–104.

    Article  PubMed  CAS  Google Scholar 

  30. Donohue JH, Nagorney DM, Grant CS, et al. 1990. Carcinoma of the gallbladder. Does radical resection improve outcome? Arch Surg 125:237–241.

    Article  PubMed  CAS  Google Scholar 

  31. Opura Y, Mizuraoto R, Isaji S, et al. 1991. Radical operations for carcinoma of the gallbladder: Present status in Japan. World J Surg 15:337–343.

    Article  Google Scholar 

  32. Gagner M, Rossi R. 1991. Radical operations for carcinoma of the gallbladder: Present study in North America. World J Surg 15:344–347.

    Article  PubMed  CAS  Google Scholar 

  33. Shirai Y, Yoshida K, Tsukada K, et al. 1992. Inapparent carcinoma of the gallbladder. An appraisal of a radical second operation after simple cholecystectomy. Ann Surg 215: 326–331.

    Article  PubMed  CAS  Google Scholar 

  34. Fahim RB, McDonald JR, Richard JC, et al. 1962. Carcinoma of the gallbladder: A study of its modes of spread. Ann Surg 156:114–124.

    Article  PubMed  CAS  Google Scholar 

  35. Kopelson G, Harisiadis L, Tretter P, et al. 1977. The role of radiation therapy in cancer of the extra-hepatic biliary system: An analysis of thirteen patients and a review of the literature of the effectiveness of surgery, chemotherapy and radiotherapy. Int J Radiat Oncol Biol Phys 2:883–894.

    Article  PubMed  CAS  Google Scholar 

  36. Nagashima H, Watanabe A, Hayashi S, et al. 1982. Primary carcinoma of the gallbladder and the extrahepatic bile duct. Gastroenterology 17:246–253.

    CAS  Google Scholar 

  37. Hanna SS, Ride WD. 1978. Carcinoma of the gallbladder or extrahepatic bile ducts: The role of radiotherapy. Can Med Assoc J 118:59–61.

    PubMed  CAS  Google Scholar 

  38. Pilepich MV. 1978. Radiotherapy in carcinoma of the gallbladder. In: HJ Wanebo (ed): Hepatic and Biliary Cancer. New York, Marcel Dekker, pp 447–452.

    Google Scholar 

  39. Treadwell TA, Harding WJ. 1976. Primary carcinoma of the gallbladder. The role of adjunctive therapy in its treatment. Am J Surg 132:703–706.

    Article  PubMed  CAS  Google Scholar 

  40. Todoroki T, Iwasaki Y, Orii K, et al. 1991. Resection combined with intraoperative radiation therapy (IORT) for Stage IV (TNM) gallbladder carcinoma. World J Surg 15:356–366.

    Article  Google Scholar 

  41. Busse PM, Cady B, Bothe A Jr., et al. 1991. Intraoperative radiation therapy for carcinoma of the gallbladder. World J Surg 15:352–356.

    Article  PubMed  CAS  Google Scholar 

  42. Davis HL, Jr. Ramirez G, Ansfield FJ. 1974. Adenocarcinoma of stomach, pancreas, liver and biliary tree. Cancer 33:193–197.

    Article  PubMed  Google Scholar 

  43. Haskell CM. 1980. Cancer of the liver. In: CM Haskell (ed): Cancer Treatment. Philadelphia: WB Saunders, pp 319–357.

    Google Scholar 

  44. Falkson G, MacIntyre JM, Moertel CG. 1984. Eastern Cooperative Oncology Group experience with chemotherapy for inoperable gallbladder and bile duct cancer. Cancer 54:965–969.

    Article  PubMed  CAS  Google Scholar 

  45. Crooke ST, Bradner WT. 1976. Mitomycin-C: A review. Cancer Treat Rev 3:121–139.

    Article  PubMed  CAS  Google Scholar 

  46. von Eyben F, Hellekant C, Mattson M, et al. 1980. Mitomycin-C in advanced gallbladder carcinoma. Acta Radiol (Oncol) 19:81–84.

    Article  Google Scholar 

  47. Adolphson CC, Carpenter JT Jr. 1982. Response to doxorubicin and mitomycin in cholangiocarcinoma: A case report. Cancer Treat Rep 66:209–210.

    PubMed  CAS  Google Scholar 

  48. Misra NC, Jaiswal MSD, Singh RV, et al. 1977. Intrahepatic arterial infusion of combination mitomycin-C and 5-fluorouracil in treatment of primary and metastatic liver carcinoma. Cancer 39:1425–1429.

    Article  PubMed  CAS  Google Scholar 

  49. Schmeck HJ, Bartels E, Viets CH, et al. 1986. Intraductale Chemotherapie eines gallen-gagskarcinoms mit 5-fluorouracil. Klin Wochenschr 64:713–716.

    Article  PubMed  CAS  Google Scholar 

  50. Oswalt CE, Cruz AB. 1977. Effectiveness of chemotherapy in addition to surgery in treating carcioma of the gallbladder. Rev Surg 34:436–438.

    PubMed  CAS  Google Scholar 

  51. Polk HC. 1966. Carcinoma of the calcified gallbladder. Gastroenterology 50:582–585.

    PubMed  Google Scholar 

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© 1994 Springer Science+Business Media Dordrecht

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Wanebo, H.J., Vezeridis, M.P. (1994). Treatment of gallbladder cancer. In: Sugarbaker, P.H. (eds) Hepatobiliary Cancer. Cancer Treatment and Research, vol 69. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2604-9_10

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  • DOI: https://doi.org/10.1007/978-1-4615-2604-9_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6115-2

  • Online ISBN: 978-1-4615-2604-9

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