Abstract
Elasticity imaging is based on two processes. The first is the evaluation of the mechanical response of a stressed tissue using imaging modalities, e.g. ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) scans and Doppler ultrasound. The second step is depiction of the elastic properties of internal tissue structures by mathematical solution of the inverse mechanical problem. The evaluation of elastic properties of tissues has the potential for being an important diagnostic tool in the detection of cancer as well as other injuries and diseases. The success of breast self-examination in conjunction with mammography for detection and continuous monitoring of lesions has resulted in early diagnosis and institution of therapy. Self-examination is based on the manually palpable texture difference of the lesion relative to adjacent tissue and, as such, is limited to lesions located relatively near the skin surface and increased lesion hardness with respect to the surrounding tissue. Imaging of tissue “hardness” should allow more sensitive detection of abnormal structures deeper within tissue. Tissue hardness can actually be quantified in terms of the tissue elastic moduli and may provide good contrast between normal and abnormal tissues based on the large relative variation in shear (or Young’s) elastic modulus.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Potts RO, Chrisman DA, and Buras EM, Jr. 1983, The dynamic mechanical properties of human skin in vivo. J Biomechanics 16, 365–372.
Sarvazyan AP. 1983, Biophysical basis of ultrasonic medical diagnostics, In: Ultrasonic Diagnostic (Rus.), Institute of Applied Physics, Gorky, 80–94.
Madigosky WM, Lee GF, Haun J, Borkat F, and Kotaoka R. 1986, Acoustic surface wave measurement on live bottlenose dolphins, J Acoust Soc Am 79,153–159.
Dorogi PM, Dewitt GM, Stone BR, Buras EM, Jr. 1986, Viscoelastometry of skin in vivo using shear wave propagation, Bioeng Skin 2, 59–70.
Pereira JM, Mansour JM, Davis BR 1990, Analysis of shear wave propagation in skin; application to an experimental procedure, J Biomechanics 23(8), 745–751.
Pereira JM, Mansour JM, Davis BR 1991, The effects of layer properties on shear disturbance propagation in skin, J Biomechanics Engineering 113, 30–35.
Vucelic D, Sarvazyan AP. 1989, Surface acoustic waves in medical diagnostics. Procs. 13th Intl. Cong. Acoust., Belgrade, 4, 151–154.
von Gierke HE, Oestreicher HL, Franke EK, Parrack HO, and von Wittern WW. 1952, Physics of vibration in living tissues, J Appl Physiol 4, 886–900.
Pasechnik VL, Sarvazyan AP. 1969, On the possibility of examination of muscle contraction models by measuring the viscoelastic properties of the contracting muscle, Studia Biophys 13, 143–150.
Fung YC. 1981, Biomechanics-mechanical properties of living tissues, Springer-Verlag; New York.
Krouskop TA, Dougherty DR, Levinson SF. 1987, A pulsed Doppler ultrasonic system for making noninvasive measurements of the mechanical properties of soft tissue, J Rehabil Res Dev 24(2), 1–8.
Kazakov VV, Klochkov BN, Chichagov PK. 1989, The study of dispersive characteristics of a wave on a human body. In: Methods of vibrational diagnostics of rheological properties of soft materials and biological tissues, Ed. V.A. Antonets, Institute of Applied Physics publications, Gorky.
Mase GE. 1970, Theory and problems of continuum mechanics, In Schaum’s outline series, McGraw-Hill Book Company, New York.
Chivers RC, Parry RJ. 1978, Ultrasonic velocity and attenuation in mammalian tissues, J Acoust Soc Am 63(3), 940–953.
Goss SA, Johnson RL and Dunn F. 1978, Comprehensive compilation of empirical ultrasonic properties of mammalian tissues, J Acoust Soc Am 64, 423–457.
Duck FA. 1990, Physical properties of tissues. Academic Press.
Sarvazyan AP, Shnol SE, Pasechnic VL. 1969, Acoustical properties of gels and biological tissues in the low frequency sound fields. In: Properties and function of macromolecules and macromolecular systems Ed. G.M. Frank, Moscow, Nauka, 121–134.
Sarvazyan AP. 1969, Low velocity of sound in gels and biological tissues. PhD thesis, Pushchino, Institute of Biophysics, USSA Acad. Sei., 99.
Sarvazyan AP. 1975, Low frequency acoustical characteristics of biological tissues, Mechanics of Polymers 4, 691–695.
Frizzell LA, Carstensen EL, Franke EK, Parrack HO, and von Wittern WW. 1952, Physics of vibration in living tissues, J Appl Physiol 4, 886–900.
Madsen EL, Sathoff HJ, Zagzebski JA. 1983, Ultrasonic shear wave properties of soft tissues and tissuelike materials, J Acoust Soc Am 74, 1346–1355.
Malenkov AG, Asoian KV. 1983, Correlation of acoustic characteristics and probable origin of a mouse liver tumor, Biofizika 28(2), 326–329.
Pashovkin TN, Sarvazyan AP. 1989, Mechanical characteristics of soft biological tissue. In: Methods of vibrational diagnostic of rheological properties of soft materials and biological tissues. Ed. V.A. Antonents, Institute of Applied Physics publication, Gorky, 105.
Burke TM, Blankenberg TA, Sui AKQ, Blankenberg FG, Jensen HM. 1990, Preliminary results for shear wave speed of sound and attenuation coefficients from excised specimens of human breast tissue, Ultrasonic Imaging 12, 99–118.
Parker KJ, Huang SR, Musulin RA, Lerner RM. 1990, Tissue reponse to mechanical vibrations for “sonoelasticity imaging”, Ultrasound Med Biol 16(3), 241–246.
Sarvazyan AP, Skovoroda AR, Vucelic D. 1992, Utilization of surface acoustic waves and shear acoustic properties for imaging and tissue characterization, in Acoustic Imaging, Ermert, H, Harjes, HP, (eds) v. 19, 463–467, Plenum Press, New York.
Sarvazyan AP, Kiemin VI. 1979, Unpublished results.
Sadowsky M. 1928, Z Angew Math Mech 8, 107.
Sarvazyan AP, Ponomarjev V, Vucelic D, Popovic G, Veksler A. 1990, Method and device for acoustic testing of elasticity of biological tissues. United States Patent #4,957,851, August 14, 1990.
Modjanova EA. 1974, Ontogenez 7, 1022.
Modjanova EA, Malenkov AG. 1973, Alteration of properties of cell contacts during progression of hepatomas, Experimental Cell Research 76(2), 305–314.
Dickinson RJ and Hill CR. 1982, Measurement of soft tissue motion using correlation between A-scans. Ultrasound Med Biol 8, 263–271.
Tristam M, Barbosa DC, Cosgrove DO, Nassiri DK, Bamber JC, Hill CR. 1986, Ultrasonic study of in vivo kinetic characteristics of human tissue. Utrasound Med Biol 12, 927–937.
Tristam M, Barbosa DC, Cosgrove DO, Bamber JC, Hill CR. 1988, Application of fourier analysis to clinical study of patterns of tissue movement. Ultrasound Med Biol 14(8), 695–707.
Lerner RM and Parker KJ. 1987, Sono-elasticity in ultrasonic tissue characterization and echographic imaging. Procs. 7th Eur. Comm. Workshop, JM Thijssen, ed., October 1987, Nijmegen, The Netherlands.
Lerner RM, Parker KJ, Holen J, Gramiak R, Waag RC 1988, Sono-elasticity: Medical elasticity images derived from ultrasound signals in mechanically vibrated targets. Acoust Imaging 16, 317–327.
Lerner RM, Huang SR, Parker KJ. 1990, “Sonoelasticity” images derived from ultrasound signals in mechanically vibrated tissues, Ultrasound Med Biol 16(3), 231–239.
Yamakoshi Y, Sato J, Sato T. 1990, Ultrasonic imaging of the internal vibration of soft tissue under forced vibration, IEEE Trans Ultras. Ferro. Freq. Cont., UFFC-37, 45–53.
Ishihara K, Tanouchi J, Kitabatake A, Uematsu M, Masuyma T, Yoshida Y, Doi Y, Kondo H, Kamada T, Kishimoto S, Ogawa T, Yokozawa N, Mulai H, Kodama M. 1990, High speed digital subtraction echography: principle and preliminary application to arteriosclerosis, arythmia and blood flow visualization, Proceedings of 1990 IEEE Ultrasonic Symposium, 2, 1473-1476.
Yamashita Y, and Kubota M, 1990, Tissue characterization from ultrasonic imaging of movement and deformation, Procs. of the 1990 Ultrasonics Symposium, 2, 1371–1375.
Meunier J, Bertrand M, Mailloux G, Petitclerc R. 1988 Assessing local myocardial deformation from speckle tracking in echography, SPIE Proc. Medical Imaging II 914, 20–29.
Ophir J, Cespedes I, Ponnekanti H, Yazdi Y, Li X. 1991, Elastography: a quantitative method for imaging the elasticity of biological tissues, Ultrasonic Imag. 13, 111–134.
Parker KJ and Lerner RM. 1992, Sonoelasticity of Organs: Shear Waves Ring a Bell, J Ultrasound Med 11(8), 387–392.
Ponnekanti H, Ophir J, Cespedes I. 1992, Axial stress distributions compressors in elastography: an analytical model,” Ultrasound Med Biol 18(8), 667–673.
Truong XT, Jarrett SR, Nguyen MC. 1978, A method for deriving viscoelastic modulus from transient pulse propagation, IEEE Trans Biomed Eng 24(4), 382–385.
O’Donnell M, Skovoroda AR, Shapo BM. 1991, Measurement of arterial wall motion using fourier based speckle tracking algorithms, Procs. of the 1991 IEEE Ultrasonics Symposium, 2, 1101–1104
Yemelyanov SY, Skovoroda AR, Lubinski MA, Shapo BM and O’Donnell M. 1992, Ultrasound elasticity imaging using Fourier based speckle tracking algorithm, Procs. of the 1992 IEEE Ultrasonics Symposium, 2, 1065–1068.
Adler RS, Rubin JM, Bland PH, Carson PL. 1989, Characterization of transmitted motion in fetal lung: Quantitative analysis, Med Phys 16(3), 333–337.
Adler RS, Rubin JM, Bland PH, Carson PL. 1990, Quantitative tissue motion analysis of digitized M-mode images: Gestational differences of fetal lung, Ultrasound Med Biol 16(6), 561–569.
Horn KP, Schunck BG. 1981, Determining Optical Flow, Artificial Intelligence 17, 185–203.
Feinberg DA, Crooks LE, Sheldon P, Hoenninger J, Watts J, Arakawa M. 1985, Magnetic resonance imaging the velocity vector components of fluid flow, Magn Reson Med 2(6), 555–566.
Feinberg DA, Jakab PD. 1990, Tissue perfusion in humans studied by Fourier velocity distribution, line scan, and echo-planar imaging, Magn Reson Med 16(2), 280–93.
Decorps M and Gourgeois D. 1991, Very Slow Flow Imaging, Magn Reson Med 19(2), 270.
Zerhouni EA, Parish DM, Rogers WJ, Yang A, and Shapiro EP. 1988, Human heart: tagging with MR imaging - a method for noninvasivee assessment of mycardial motion, Radiology 169, 164–172.
Axel L, Dougherty L. 1988, Heart wall motion: improved method of spatial modulation of magnetization for MR imaging, Radiology 169, 59–63.
Pipe JG, Boes JL, Chenevert TL. 1991, Method for measuring three-dimensional motion with tagged MR imaging, Radiology 181, 591–595.
Fowlkes JB, Emelianov SY, Pipe JG, Skovoroda AR, Adler RS, Carson PL and Sarvazyan AP. 1994, The possibility of cancer detection based on remote MRI measurements of tissue elasticity, submitted for publication in Medical Physics.
Landau LD and Liftshitz EM, 1965, Theory of elasticity, Moscow, Nauka.
Samarskii AA, Nikolaev ES. 1978, Methods of the solution of the net equations, Nauka, Moscow.
Skovoroda AR. 1992, About the diagnosis of the local pathologies in the elastic medium (3D approach), Preprint, Pushchino Scientific Center of Russian Acad. Sci., Pushchino.
Skovoroda AR, 1992, About the diagnosis of the local pathologies in the elastic medium (2D approach), Preprint, Pushchino Scientific Center of Russian Acad. Sci., Pushchino.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Sarvazyan, A.P. et al. (1995). Biophysical Bases of Elasticity Imaging. In: Jones, J.P. (eds) Acoustical Imaging. Acoustical Imaging, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1943-0_23
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1943-0_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5797-1
Online ISBN: 978-1-4615-1943-0
eBook Packages: Springer Book Archive