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Genetics of Prolactinomas

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Book cover Prolactin

Part of the book series: Endocrine Updates ((ENDO,volume 12))

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Abstract

Prolactinomas are tumors of lactotroph cells in the anterior pituitary that hypersecrete prolactin, resulting in amenorrhea and galactorrhea in women and reduced sexual function in males. Macroadenomas cause additional symptoms, including visual defects and severe headaches, and are present in 90% of males with prolactinomas (1). Prolactinomas are the most common of all pituitary adenomas and occur more frequently in females, with a 3:1 preponderance (2). Mixed tumors expressing both prolactin and growth hormone also occur, and are derived from the earlier precursor mammosomatotrophs, which diverge into lactotroph and somatotroph lineages in normal development.

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  1. Cedars-Sinai Medical Center & UCLA School of Medicine, Los Angeles, CA, USA

    Toni R. Prezant

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  1. University of Cincinnati, USA

    Nelson D. Horseman

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Prezant, T.R. (2001). Genetics of Prolactinomas. In: Horseman, N.D. (eds) Prolactin. Endocrine Updates, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1683-5_7

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  • DOI: https://doi.org/10.1007/978-1-4615-1683-5_7

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