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The Psychosomatic Interface: Hyperprolactinemia

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Prolactin

Part of the book series: Endocrine Updates ((ENDO,volume 12))

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Abstract

Prolactin is practically ignored in the chapter of psychosomatic disorders of textbooks of psychiatry (1). There are two valid reasons for this omission:

First, psychiatric difficulties associated with inappropriate lactation or hyperprolactinemia (except when induced by drugs) are uncommon. Second, there is no conceptual framework to accommodate such uncommon observations that, when reported, appear either as anecdoctal cases or as unexplained associations. For all practical and theoretical purposes the biology of “psychological stress” has been described exclusively in terms of the hypothalamic-pituitary-adrenal axis and/or the sympathetic nervous system.

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References

  1. Rubin RT, King BH Endocrine and metabolic disorders. In Kaplan H.I., Sadock B.J. eds. Comprehenive Textbook of Psychiatry, 6th ed., Baltimore, Williams & Wilkins, 1995: 1541–28.

    Google Scholar 

  2. Reichlin S. Prolactin and growth hormone in stress. In Chrousos GP, Loriaux DL, Gold PW eds. Mechanisms of physical and emotional stress. New York: Plenum Press, 1988: 353–76.

    Google Scholar 

  3. Sobrinho LG. Neuropsychiatry of prolactin: causes and effects. Bailli¨¨re’s Clinical Endocrinology and Metabolism 1991; 5:119–41.

    Article  CAS  Google Scholar 

  4. Zeitner RM, Frank MV, Freeman SMD. Pharmacogenic and psychogenic aspects of galactorrhea: a case report. Am J Psychiatry 1980; 137; 111–2.

    Article  PubMed  CAS  Google Scholar 

  5. Fava GA, Fava M, Kellner R, Serafini E, Mastrogiacomo I. Depression, hostility and anxiety in hyperprolactinemia. Psychoter Pychosom 1981; 36: 122–8.

    Article  CAS  Google Scholar 

  6. Kellner R, Buckman MT, Fava GA, Pathak D. Hyperprolactinemia, distress, and hostility. Am J Psychiatry 1984; 141: 759–63.

    PubMed  CAS  Google Scholar 

  7. Reavley S, Fisher AD, Owen D, Creed FH, Davis JRE. Psychological distress in patients with hyperprolactinemia. Clin Endocrinol 1997; 47: 343–8.

    Article  CAS  Google Scholar 

  8. Rothchild E. Psychologic aspects of galactorrhea. J Psychosom Obst Gynecol 1985; 4: 185–96.

    Article  Google Scholar 

  9. Nunes MCP, Sobrinho LG, Calhaz-Jorge C, Santos MA, Mauricio JC, Sousa MFF: Psychosomatic factors in patients with hyperprolactinemia and/or galactorrhea. Obstetrics & Gynecology 1980; 55: 591.

    CAS  Google Scholar 

  10. Assies J, Vingerhoets AJJM, Poppelaars K. Psychosocial aspects of hyperprolactinemia. Psychoneuroendocrinology 1992; 17: 673–9.

    Article  PubMed  CAS  Google Scholar 

  11. Jürgensen O, Bardé B. Psychodynamic findings in women with elevated serum prolactin. In Dennerstein L., De Senarclens M. eds. The Young Woman, Amsterdam, Excerpta Medica, 1983, 210–16.

    Google Scholar 

  12. Rojas LM, Sthory I, Canales ES, Zarate A Factores psicogénicos en el sindroma de amenorrea-galactorrea. Ginecologia y Obstetricia de México 1981; 49: 291–5.

    CAS  Google Scholar 

  13. Sobrinho LG, Nunes MCP, Calhaz-Jorge C, Afonso AM, Pereira MC, Santos MA Hyperprolactinemia in women with paternal deprivation during childhood. Obstetrics & Gynecology 1984; 64; 465–8.

    CAS  Google Scholar 

  14. Lozoff B, Felt BT, Nelson EC, Wolf AW, Meltzer HW, Jimenez E. Serum prolactin and behavior in infants. Biological Psychiatry 1995; 37; 4–12.

    Article  PubMed  CAS  Google Scholar 

  15. Theorell T. Prolactin - a hormone that mirrors passiveness in crisis situations. Integrative Physiological and Behavioral Science 1992; 27: 32–38.

    Article  PubMed  CAS  Google Scholar 

  16. Lökk J Arnetz B. Psychophysiological concomitants of organizational change in health care personnel: effects of controlled intervention study. Psychoter Psychosom 1997; 66: 74–7.

    Article  Google Scholar 

  17. Grossi G, Theorell T, Jürisoo M, Setterlind S. Psychophysiological correlates of organizational change of unemployment among police inspectors. Integr Physiol Behav Sci 1999; 34:30–42.

    Article  PubMed  CAS  Google Scholar 

  18. Di Carlo R, Muccioli G, Papotti M, Bussolati G: Characterization of prolactin receptor in human brain and choroid plexus. Brain Res 1992; 570: 341–6.

    Article  PubMed  Google Scholar 

  19. Dutt A, Kaplitt MG, Kow L-M, Pfaff DW: Prolactin, central nervous system and behavior: a critical review. Neuroendocrinology 1994; 59: 413–9.

    Article  PubMed  CAS  Google Scholar 

  20. Pi XJ; Grattan DR Distribution of prolactin receptor immunoreactivity in the brain of estrogen-treated, ovariectomized rats. J Comp Neurol, 1998; 394: 462–74.

    Article  PubMed  CAS  Google Scholar 

  21. Assies J, Schellekens APM, Touber JL. Protein hormones in cerebrospinal fluid: Evidence for retrograde transport of prolactin from the pituitary to the brain in man. Clin Endocrinol 1978; 8: 887–91.

    Article  Google Scholar 

  22. Herbert J. Peptides in the limbic system: neurochemical codes for co-ordinated adaptive responses to behavioural and physiological demand. Progress in Neurobiology 1993 41: 723–91.

    Article  PubMed  CAS  Google Scholar 

  23. Emanuele NV, Jurgens JK, Halloran MM, Tentler JJ, Lawrence Am, Kelley MR. The rat prolactin gene is expressed in brain tissue; detection of normal and alternatively spliced prolactin messenger. Mol Endocrinol 1992; 2: 35–42.

    Article  Google Scholar 

  24. Massara F, Camanni F, Martra M, Dolfin GC, Muller EE, Molinatti GM Reciprocal pattern of the TSH and PRL responses to dopamine receptor blockade in women with physiological or pathological hyperprolactinaemia. Clin Endocrinol 1983; 18: 103–10.

    Article  CAS  Google Scholar 

  25. Seki K, Kato K. Luteinizing hormone response to domperidone in hyperprolactinaemic women with pituitary microadenomas. Clin Endocrinol 1988; 28: 271–5.

    Article  CAS  Google Scholar 

  26. Drago F, D’Agata V, Iacona T, Spadaro F, Grassi M, Valerio C, Raffaele R, Astuto C, Lauria N, Vitetta M. Prolactin as a protective factor in stress induced biological changes. J Clin Lab Anal 1989; 3: 340–4.

    Article  PubMed  CAS  Google Scholar 

  27. Keverne EB. Central mechanisms underlying the neural and neuroendocrine determinants of maternal behaviour. Psychoneuroendocrinology 1988; 13: 127–41.

    Article  PubMed  CAS  Google Scholar 

  28. Bridges RS, Mann PE. Prolactin-brain interactions in the induction of maternal behavior in rats. Psychoneuroendocrinology 1994;19: 611–22.

    Article  PubMed  CAS  Google Scholar 

  29. Mc Carthy MM, Curran GH, Siegel HI. Evidence for the involvement of prolactin in the maternal behavior of the hamster. Physiology & Behavior 1994; 55: 181–4.

    Article  CAS  Google Scholar 

  30. Lucas BK, Ormandy CJ, Binart N, Bridges RS, Kelly PA. Null mutation of the prolactin receptor gene produces a defect in maternal behavior. Endocrinology 1998; 139: 4102–7.

    Article  PubMed  CAS  Google Scholar 

  31. Numan M: Neural basis of maternal behavior in the rat. Psychoneuroendocrinology 1988; 13: 47–62.

    Article  PubMed  CAS  Google Scholar 

  32. Byatt JC, Staten NR, Salsgiver WJ, Kostelc JG, Collier RJ. Stimulation of food intake and weight gain in mature female rats by bovine prolactin and bovine growth hormone. Am J Physiol (Endocrinol Metab 27) 1993; 264: E968–92.

    Google Scholar 

  33. Heil SH. Sex-specific effects of prolactin on food intake in rats. Horm Behav 1999; 35: 47–54.

    Article  PubMed  CAS  Google Scholar 

  34. Sobrinho LG, Sá-Melo P, Nunes MCP, Barroco LE, Calhaz-Jorge C, Oliveira LC, Santos MA. Sexual dysfunction in hyperprolactinemic women. Effect of bromocriptine. J Psychosomatic Obstetrics and Gynecology 1987; 6; 43–8.

    Article  Google Scholar 

  35. Berezin M, Shimon I, Hadani M. Prolactinoma iin 53 men: Clinical characteristics and modes of treatment (male prolactinoma). Clin Endocrinol 1995; 18: 436–41.

    CAS  Google Scholar 

  36. Laan E., van Lunsen RH. Hormones and sexuality in postmenopausal women: a psycho-physiological study.JPsychosom Obstet Gynecol 1997; 18: 126–33.

    Article  CAS  Google Scholar 

  37. Matera C, Freda PU, Ferin M, Wardlaw SL: Effect of chronic opioid antagonism on the hypothalamic-pituitary-ovarian axis in hyperprolactinemic women. J Clin Endocrinol Metab 1995; 80: 540–5.

    Article  PubMed  CAS  Google Scholar 

  38. Terkel J: Neuroendocrine processes in the establishment of pregnancy and pseudopregnancy in rats. Psychoneuroendocrinology 1988; 13: 5–28.

    Article  PubMed  CAS  Google Scholar 

  39. Wieschhoff HA. Artificial stimulation of lactation in primitive cultures. Bulletin of the History of Medicine 1940; 8: 1403–15.

    Google Scholar 

  40. Scarpa A. Etnomedicina. Milan, Franco Lucisano, 1979: 475–86.

    Google Scholar 

  41. Auerbach KG and Avery JL. Induced lactation American Journal of Diseases in Children 1981; 135: 340–3.

    CAS  Google Scholar 

  42. Bowman LA, Dilley SR, Keverne EB. Suppression of estrogen-induced LH surges by social subordination in talapoin monkeys. Nature 1978; 275: 56–8.

    Article  PubMed  CAS  Google Scholar 

  43. Dixon AF, George L Prolactin and parental behavior in a male New World primate. Nature 1982; 299: 551–553.

    Article  Google Scholar 

  44. Ziegler TE, Wegner FH, Snowdon CT. Hormonal responses to parental and non-parental conditions in male cotton-top tamarins, Saguinus oedipus, a New World primate. Horm Behav 1996; 30: 287–297.

    Google Scholar 

  45. Reburn CJ, Wynne-Edwards KE Hormonal changes in males of a naturally biparental and a uniparental mammal. Horm Behav 1999; 35: 163–176.

    Article  PubMed  CAS  Google Scholar 

  46. La Fuente JR, Rosenbaum AH. Prolactin in psychiatry. Am J Psychiatry 1981; 138: 1154–60.

    PubMed  Google Scholar 

  47. Nicholas L, Dawkins K, Golden RN. Psychoneuroendocrinology of depression. Prolactin. Psychiatr Clin N Am 1998; 21: 341–58.

    Article  CAS  Google Scholar 

  48. Chesson A, Levine S, Kong L, Lee S. Neuroendocrine evaluation in Kleine-Levin syndrome: evidence of reduced dopaminergic tone during periods of hypersomnolence. Sleep 1991; 14:226–32.

    PubMed  Google Scholar 

  49. Bamford CR. Menstrual-associated sleep disorder: an unusual hypersomniac variant associated with both menstruation and amenorrhea with a possible link to prolactin and metoclopramide. Sleep 1993; 16: 484–6.

    PubMed  CAS  Google Scholar 

  50. Oribe E, Amini R, Nissenbaum E, Boat B: Serum prolactin concentrayios are elevated after syncope. Neurology 1996; 47: 60–2.

    Article  PubMed  CAS  Google Scholar 

  51. Meierkord H, Shorvon S, Lightman SL. Plasma concentrations of prolactin, noradrenalin, vasopressin and oxytocin during and after a prolonged epileptic seizure. Acta Neurol Scand 1994; 90: 73–7.

    Article  PubMed  CAS  Google Scholar 

  52. Lin YY, Su MS, Yiu CH, Shih YH, Yen DJ, Kwan SY, Wu ZA, Chan SHH. Relationship between mesial temporal seizure focus and elevated serum prolactin in temporal lobe epilepsy. Neurology 1997; 49: 528–32

    Google Scholar 

  53. Devane GW, Vera MI, Buhl WC, Kalra PS. Opioid peptides in pseudocyesis. Obstet Gynecol 1985; 65: 183–8.

    PubMed  CAS  Google Scholar 

  54. Osotimehin BO, Ladipo AO, Adejuwon CA, Otolorin EO. Int J Gynaecology and Obstetrics 1981; 19: 399–402.

    CAS  Google Scholar 

  55. Yen SSC, Rebar RW, Quesenberry W. Pituitary function in pseudocyesis. J Clin Endocrinol Metab 1976; 43: 132–6.

    Article  PubMed  CAS  Google Scholar 

  56. Zarate A, Canales ES, Soria J, Jacobs LS, Daughaday WH, Kastin Ai, Schally AV. Gonadotropin and prolactin secretion in human pseudocyesis. Annales d’Endocrinologie (Paris) 1974; 35: 445–50.

    CAS  Google Scholar 

  57. Bray MA, Muneyyirci-Delale O, Kofinas G, Reyes FI. Circadian, ultradian, and episodic gonadotropin and prolactin secretion in human pseudocyesis. Acta Endocrinol 1991; 124: 501–9.

    PubMed  CAS  Google Scholar 

  58. Starkman M, Marshall JC, La Ferla J, Kelch RP. Pseudocyesis: psychologic and neuroendocrine relationships. Psychosomatic Medicine 1985; 47: 46–57.

    PubMed  CAS  Google Scholar 

  59. Tulandi T, McInnes RA, Lal S. Altered pituitary hormone secretion in patients with pseudocyesis. Fertil & Steril 1983; 40: 637–41.

    CAS  Google Scholar 

  60. Aruffo RN. Lactation as a denial of separation. Psychoanal Quart 1971;40: 100–22.

    CAS  Google Scholar 

  61. Briehl W, Kulka W. Lactation in a virgin. Psychoanal Quart 1935; 4: 484–511.

    Google Scholar 

  62. Corenblum B, Whitaker M. Inhibition of stress-induced hyperprolactinemia. Brit Med J 1977;2:1328.

    Article  PubMed  CAS  Google Scholar 

  63. Biondi M, Picardi A. Psychological stress and neuroendocrine function in humans: the last two decades of research. Psychoter Psychosom 1999; 68: 114–50.

    Article  CAS  Google Scholar 

  64. Ratner A, Yelvington DB, Rosenthal M. Prolactin and corticosterone response to repeated footshock stress in male rats. Psychoneuroendocrinology 1989; 14: 393–6.

    Article  PubMed  CAS  Google Scholar 

  65. Krüger T, Exton MS, Pawlak C, von zur Mühlen A, Hartman U, Schedlowski M. Neuroendocrine and cardiovascular response to sexual arousal and orgasm in men. Psychoneuroendocrinology 1998; 23: 401–11.

    Article  PubMed  Google Scholar 

  66. Exton MS, Bindert A, Krüger T, Scheirer F, Hartman U, Schledowski M. Cardiovascular and endocrine alterations after masturbation-induced orgasm in women. Psychosomatic Medicine 1999; 61: 280–9.

    PubMed  CAS  Google Scholar 

  67. Buckman MT, Kellner R. Reduction of distress in hyperprolactiemia with bromocriptine. Am J Psychiatry 1985; 142: 242–4.

    PubMed  CAS  Google Scholar 

  68. Sonino N, Fava GA, Boscaro M: A role for life-events in the pathogenesis of Cushing’s disease. Clin Endocrinol 1993; 38: 261–4.

    Article  CAS  Google Scholar 

  69. Burrow GN, Wortzman G, Rewcastle RB, Holgate RC, Kovacs K. Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N. Engl. J Med 1981; 304: 156–8.

    Article  PubMed  CAS  Google Scholar 

  70. Studer H, Derwhal M. Mechanisms of nonneoplastic endocrine hyperplasia.a changing concept: a review focused on the thyroid gland. End Rev 1995; 16: 411.

    CAS  Google Scholar 

  71. Asa S, Kovacs K, Stefaneau L, Horvath E, Billestrup N, Gonzalez-Manchon C, Vale W. Pituitary mammosomatotroph adenomas develop on old mice transgenic for growth-hormone releasing hormone. Proc Soc Exptl Biol Med 1990; 193: 232–5.

    CAS  Google Scholar 

  72. Zimmerman D, Young WF, Ebersold MJ, Scheithauer BW, Kovacs K, Horvath E, Whitaker MD, Eberhardt NL, Down TR, Frohman LA: Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. J Clin Endocrinol Metab 1993; 76: 216–22

    Google Scholar 

  73. Saiardi A; Bozzi Y; Baik JH; Borrelli E. Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia. Neuron 1997; 19, 115–26.

    Article  PubMed  CAS  Google Scholar 

  74. Gooren LJG, Assies J, Asscheman H, De Siegte R, Van Kessel H. Estrogen-induced prolactinoma in a man. J Clin Endocrinol Metab 1988; 66.444–6.

    Article  PubMed  CAS  Google Scholar 

  75. Kovacs K, Stefaneau L, Ezzat S, Smyth HS. Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study. Arch Path Lab Med 1994; 118: 562–5.

    PubMed  CAS  Google Scholar 

  76. Serri O, Noiseux D, Robert F, Hardy J. Lactotroph hyperplasia in an estrogen treated male-to-female transexual patient. J Clin Endocrinol Metab 1996; 81; 3177–9.

    Article  PubMed  CAS  Google Scholar 

  77. Scheithauer BW, Sano T, Kovacs KT, Young Jr WF, Ryan N, Randall RV. The pituitary gland in pregnancy: a clinicopathologic and immunocytochemical study of 69 cases. Mayo Clinic Proceedings 1990; 65: 461–74.

    PubMed  CAS  Google Scholar 

  78. Pituitary adenoma study group. Pituitary adenomas and oral contraceptives: a multicenter case-control study. Fertil Steril 1983; 39: 753–60.

    Google Scholar 

  79. Ferreira MF, Sobrinho LG, Pires JS, Silva MES, Santos MA, Sousa MFF. Endocrine and psychological evaluation of women with recent weight gain. Psychoneuroendocrinology 1995; 20: 53–63.

    Article  PubMed  CAS  Google Scholar 

  80. Ferreira MF, Sobrinho LG, Santos MA, Sousa MFF, Uvnäs-Moberg K. Weight gain, at least in some women, is an expression of a neuroendocrine state characterized by reduced hypothalamic dopaminergic tone. Psychoneuroendocrinology 1998; 23:1005–13.

    Article  PubMed  CAS  Google Scholar 

  81. Uvnäs-Moberg K. Role of efferent and afferent vagal nerve activity during reproduction: integrating function of oxytocin on metabolism and behavior. Psychoneuroendocrinology 1994; 19: 687–695.

    Article  PubMed  Google Scholar 

  82. Liu JW, Ben Jonathan N. Prolactin-releasing activity of neurohypophysial hormones: structure-function relationship. Endocrinology 1994; 134: 114–8.

    Article  PubMed  CAS  Google Scholar 

  83. Dépôt M, Caillé G, Mukherjee J, Katzman MA, Cadieux A, Bradwejn J. Acute and chronic role of 5-HT3 neuronal system on behavioral and neuroendocrine changes induced by intravenous cholecystokinin tetrapeptide administration in humans. Neuropsychopharmacology 1999; 20: 177–87.

    Article  PubMed  Google Scholar 

  84. Sorensen RL. Lactogen control of pancreatic islet cells. This book.

    Google Scholar 

  85. Sandler J, Dare C, Holder A. The patient and the analyst. London, Allen and Unwin, 1973: 73.

    Google Scholar 

  86. Sobrinho LG, Almeida-Costa JM. Hyperpprolactinemia as a result of immaturity or regression: the concept of maternal subroutine. Psychoter Psychosom 1992; 57: 128–32.

    Article  CAS  Google Scholar 

  87. Akistal HS Mood disorders: clinical features. In: Kaplan H.I., Sadock B.J. eds. Comprehensive Textbook of Psychiatry, 6th ed., Baltimore, Williams & Wilkins, 1995: 1123–52.

    Google Scholar 

  88. Lam RW and Stewart JN. The validity of atypical depression in DSM-IV. Comprehensive Psychiatry 1996; 37: 375–383.

    Article  PubMed  CAS  Google Scholar 

  89. American Psychiatric Association: Diagnostic and Statistic Manual of Psychiatric Disorders, 4th ed., American Psychiatric Association, Washington, 1994: 384–6.

    Google Scholar 

  90. Cincotta AH, Schiller BC, Meier AH. Bromocriptine inhibits the seasonally occurring obesity, hyperinsulinemia, insulin resistance and impaired glucose tolerance in the Syrian Hamster, Mesocricetus auratus. Metabolism 1991; 40: 639–44.

    Article  PubMed  CAS  Google Scholar 

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Sobrinho, L.G. (2001). The Psychosomatic Interface: Hyperprolactinemia. In: Horseman, N.D. (eds) Prolactin. Endocrine Updates, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1683-5_6

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  • DOI: https://doi.org/10.1007/978-1-4615-1683-5_6

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