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Prolactin Receptors

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Prolactin

Part of the book series: Endocrine Updates ((ENDO,volume 12))

Abstract

The initial step in the mechanism of action of prolactin (PRL) is the binding to a cell surface receptor. Binding of PRL to its receptor occurs with a high affinity (association constants range from 107 to 1010 M-1) and a structural specificity. PRL receptors (PRLR) have been identified in a number of cell types and tissues in several species including non-mammalian vertebrates. PRLR belongs to the class I cytokine receptor superfamily. Signal transduction by the PRLR is mainly mediated by two families of signaling molecules; the Janus tyrosine kinases and the signal transducers and activators of transcription (STATs). Disruption of the PRLR gene has provided a new mouse model with which to identify functions directly associated with PRL. Several phenotypes have been analyzed which are described in this review. Applied to the SAGE technology, the PRLR knock-out model allows the quantitative and qualitative evaluation of the expression patterns of hepatic genes in two physiological situations: transcriptomes corresponding to livers from both wild type and PRLR KO mice are being compared, and following statistical analyses, candidate genes presenting a differential profile will be further characterized.

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References

  1. Bergeron JM, Searle N, Khan MN, Posner BI. Differential and analytical subfractionation of rat liver components internalizing insulin and prolactin. Biochemistry 1986;25:1756–64.

    Article  PubMed  CAS  Google Scholar 

  2. Bergeron JM, Posner BI, Josefszberg Z, Sikstrom R. Intracellular polypeptide hormone receptors. The demonstration of specific binding sites for insulin and human growth hormone in Golgi fractions isolated from the liver of female rats. J Biol Chem 1978;253:4058–66

    PubMed  CAS  Google Scholar 

  3. Djiane J, Delouis C, Kelly PA. Prolactin receptor turnover in explants of pseudopregnant rabbit mammary gland. Mol Cell Endocrinol 1982;25;163–70

    Article  PubMed  CAS  Google Scholar 

  4. Ymer SI, Kelly PA, Herington AC, Djiane J. Immunological relationship and binding capacity of prolactin receptors in cytosolic and membrane fractions of rabbit mammary gland. Mol Cell Endocrinol 1987;53;67–73

    Article  PubMed  CAS  Google Scholar 

  5. Postel-Vinay MC, Belair L, Kaiser C, Kelly PA, Djiane J. Identification of prolactin and growth hormone binding proteins in milk. Proc Natl Acad Sci USA 1991;88;6687–90

    Article  Google Scholar 

  6. Buckley AR, Crowe PD, Russel DI-1. Rapid activation of a protein kinase C in isolated rat liver nuclei by prolactin, a known hepatic mitogen. Proc Natl Acad Sci USA 1988;85;8649–53

    Article  PubMed  CAS  Google Scholar 

  7. Perrot-Applanat M, Gualillo O, Buteau H, Edery M, Kelly PA. Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation. J Cell Sci 1997;110;123–132

    Google Scholar 

  8. Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor: Actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev 1998;19;225–68

    Article  PubMed  CAS  Google Scholar 

  9. Djiane J, Durand P, Kelly PA. Evolution of prolactin receptors in rabbit mammary gland during pregnancy and lactation. Endocrinology 1977;100;1348–56

    Article  PubMed  CAS  Google Scholar 

  10. Djiane J, Clauser H, Kelly PA. Rapid down-regulation of prolactin receptors in mammary gland and liver. Biochem Biophys Res Commun 1979;90;1371–78

    Article  PubMed  CAS  Google Scholar 

  11. Posner BI, Kelly PA, Friesen HG. Prolactin receptors in rat liver: possible induction by prolactin. Science 1975;188;57–9

    Article  PubMed  CAS  Google Scholar 

  12. Norstedt G, Husman B, Mode A, Eneroth P, Lewis UJ, Gustafsson JA. Induction of prolactin receptors in the liver is more closely related to the growth-promoting than to the lactogenic potency of peptides. Acta Endocrinol (Copenh) 1987;114;350–6

    CAS  Google Scholar 

  13. Djiane J, Kelly PA, Katoh M, Dusanter-Fourt I. Prolactin receptor: identification of the binding unit by affinity labelling and characterization of poly and monoclonal antibodies. Horm Res 1985;22;179–88

    Article  PubMed  CAS  Google Scholar 

  14. Boutin JM, Jolicoeur C, Okamura H, Gagnon J, Edery M, Shirota M, Banville D, Dusanter-Fourt I, Djiane J, Kelly PA. Cloning and expression of the rat prolactin receptor, a member of the growth hormone/ prolactin receptor gene family. Cell 1988;53;69–77

    Article  PubMed  CAS  Google Scholar 

  15. Bazan F. A novel family of growth factor receptors: a commonn binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and p75 IL-2 receptor b-chain. Biochem Biophys Res Commun 1989;164;788–95

    Article  PubMed  CAS  Google Scholar 

  16. Wells JA, De Vos AM. Hematopoietic receptor complexes. Annu Rev Biochem 1996;65;609–34

    Article  PubMed  CAS  Google Scholar 

  17. Arden KC, Boutin J-M, Djiane J, Kelly PA, Cavenee WK. The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5. Cytogenet Cell Genet 1990;53;161–5

    Article  PubMed  CAS  Google Scholar 

  18. Davis JA, Linzer DJH. Expression of multiple forms of the prolactin receptor. Mol Endocrinol 1989;3;674–80

    Article  PubMed  CAS  Google Scholar 

  19. Somers W, Ultsch M, De Vos AM, Kossiakoff AA. The X-ray structure of the growth hormone-prolactin receptor complex. Nature 1994;372;478–81

    Article  PubMed  CAS  Google Scholar 

  20. Royster M, Driscoll P, Kelly PA, Freemark M. The prolactin receptor in the fetal rat: cellular localization of messenger RNA, immunoreactive protein, and ligand binding activity and induction of expression in late gestation. Endocrinology 1995;136;3892–900

    Article  PubMed  CAS  Google Scholar 

  21. Gertler A, Petridou B, Kriwi GG, Djiane J. Interaction of lactogenic hormones with purified recombinant extracellular domain of rabbit prolactin receptor expressed in insect cells. FEBS Lett 1993;319;277–81

    Article  PubMed  CAS  Google Scholar 

  22. Hooper KP, Padmanabhan R, Ebner KE. Expression of the extracellular domain of the rat liver prolactin receptor and its interaction with ovine prolactin. 1993 J Biol Chem;268;22347–52

    PubMed  CAS  Google Scholar 

  23. Goffin V, Shivericck KT„ Kelly PA, Martial JA. Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen and related proteins in mammals. Endocr Rev 1996;17;385–410

    PubMed  CAS  Google Scholar 

  24. Goffin V, Kinet S, Ferrag F, Binart N, Martial JA, Kelly PA. Antagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassay. J Biol Chem 1996;271;16573–9

    Article  PubMed  CAS  Google Scholar 

  25. Fuh G, Wells JA. Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. J Biol Chem 1995;270;13133–7

    Article  PubMed  CAS  Google Scholar 

  26. Nicoll CS, Bern H. On the actions of PRL among the vertebrates: is there a common denominator ? In: Wolstenholme G, Knight J editors. Lactogenic Hormone. London: Churchill Livingstone 1972;299–327

    Google Scholar 

  27. Ormandy CJ, Camus A, Barra J, Damotte D, Lucas BK, Buteau H, Edery M, Brousse N, Babinet C, Binart N, Kelly PA. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 1997; 11;167–78

    Article  PubMed  CAS  Google Scholar 

  28. Horseman ND, Zhao W, Montecino-Rodriguez E, Tanaka M, Nakashima K, Engle SJ, Smith F, Markoff E, Dorshkind K. Defective mammopoiesis, but normal hematopoiesis, in mice with atargeted disruption of the prolactin gene. EMBO J 1997;16 ;6926–35

    Article  PubMed  CAS  Google Scholar 

  29. Roblero L.,Garavagno A. Effect of estradio117-beta and progesterone on oviductal transport and early development of mouse embryos. J Reprod Fertil 1979 ;57 ;91–5

    Article  PubMed  CAS  Google Scholar 

  30. Galosy S, Talamantes F. Luteotropic action of placental lactogens at mid pregnancy in the mouse. Endocrinology 1995 ;136 ;3993–4003

    Article  PubMed  CAS  Google Scholar 

  31. O’Neill C, Quinn P. Interaction of uterine flushings with mouse blastocysts in vitro as assessed by the incorporation of [3H] uridine. J Reprod Fertil 1981 ;62 ;257–62

    Article  PubMed  Google Scholar 

  32. Reese J, Binart N, Brown N, Ma WG, Paria BC, Das SK, Kelly PA, Dey SK. Implantation and decidualisation defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR. Endocrinology 2000 ;141 ;1872–81

    Article  PubMed  CAS  Google Scholar 

  33. Hogan BL. Bone morphogenetic protein: multifunctional regulators of vertebrate development. Genes Dev 1996 ;10 ;1580–94

    Article  PubMed  CAS  Google Scholar 

  34. Cross NA, Hillman LS, Allen SH, Krause GF. Changes in bone mineral density and markers of bone remodeling during lactation and post weaning in women consuming high amounts of calcium. J Bone Miner Res 1995 ;10 ;1312–20

    Article  PubMed  CAS  Google Scholar 

  35. Schlechte JA. Clinical impact of hyperprolactinemia. Baillere Clin Endocrinol Metab 1995 ;9 ;359–66

    Article  CAS  Google Scholar 

  36. Sowers MF, Hollis BW, Shapiro B, Randolph J, Janney CA, Zhang D, Schork A, Crutchfield M, Syanczyk F, Russel-Aulet M. Elevated levels of parathyroid hormone-related peptide associated with lactation and bone density loss. JAMA 1996 ;276 ;549–54

    Article  PubMed  CAS  Google Scholar 

  37. Lopez JM, Gonzalez G, Reyes V, Campino C, Diaz S. Bone turnover and density in healthy women during breastfeeding and after weaning. Osteoporos Int 1997 ;6 ;153–9

    Article  Google Scholar 

  38. Freemark M, Driscoll P, Maaskant R, Petryk A, Kelly PA. Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differntiation and development. J Clin Invest 1997 ;99 ;1107–17

    Article  PubMed  CAS  Google Scholar 

  39. Bataille-Simoneau N, Gerland K, Chappard D, Basle MF.,Mercier L. Expression of prolactin receptors in human osteosarcoma cells. Biochem Biophys Res Commun 1996 ;229 ;323–8

    Article  PubMed  CAS  Google Scholar 

  40. Clement-Lacroix P, Ormandy C, Lepescheux L, Ammann P, Damotte D, Goffin V, Bouchard B, Amling M, Gaillard-Kelly M, Binart N, Baron R, Kelly PA. Osteoblasts are a new target for prolactin/analysis of bone formation in prolactin receptor knockout mice. Endocrinology 1999 ;140 ;96–105

    Article  PubMed  CAS  Google Scholar 

  41. Bridges RS, Numan M, Ronsheim PM, Mann PE, Lupini CE. Central prolactin infusions stimulate maternal behavior in steroid-treated,nulliparous female rats. Proc Natl Acad Sci USA 1990 ;87 ;8003–7

    Article  PubMed  CAS  Google Scholar 

  42. Bridges RS Dibiase R, Loundes DD, Doherty PC. Prolactin stimulation of maternal behavior in female rats. Science 1985 ;227 ;782–4

    Article  PubMed  CAS  Google Scholar 

  43. Lucas BK.,Ormandy C.,Binart N.,Bridges RS.,Kelly PA. Null mutation of the prolactin receptor gene produces a defect in maternal behavior. Endocrinology 1998 ;139 ;4102–7

    Article  PubMed  CAS  Google Scholar 

  44. Crawley JN, Paylor R. Aproposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Horm Behav 1997 ;31 ;197–211

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. INSERM U344, Faculte de Medecine Necker, Paris, France

    Marc Edery, Nadine Binart, Brigitte Bouchard, Vincent Goffin & Paul A. Kelly

Authors
  1. Marc Edery
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  2. Nadine Binart
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  3. Brigitte Bouchard
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  4. Vincent Goffin
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  5. Paul A. Kelly
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Editor information

Editors and Affiliations

  1. University of Cincinnati, USA

    Nelson D. Horseman

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© 2001 Springer Science+Business Media New York

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Edery, M., Binart, N., Bouchard, B., Goffin, V., Kelly, P.A. (2001). Prolactin Receptors. In: Horseman, N.D. (eds) Prolactin. Endocrine Updates, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1683-5_17

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  • DOI: https://doi.org/10.1007/978-1-4615-1683-5_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5676-9

  • Online ISBN: 978-1-4615-1683-5

  • eBook Packages: Springer Book Archive

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