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Lymphocytic Hypophysitis

  • Chapter
Pituitary Tumors in Pregnancy

Part of the book series: Endocrine Updates ((ENDO,volume 15))

Abstract

Lymphocytic hypophysitis is an unusual disorder of the pituitary gland that presents with a sellar mass and/or hypopituitarism, most often associated with pregnancy and the postpartum period. Goudie and Pinkerton described the first case in 1962 in a 22 year old woman who developed postpartum amenorrhea and hypothyroidism 1. Fourteen months after childbirth, she developed shock during an appendectomy and died. Postmortem examination revealed lymphocytic thyroiditis, atrophic adrenals, and a lymphocytic infiltration of the pars anterior and pars intermedia of the pituitary gland. Giant cells and granulomas were absent in the pathologic specimen, and there was no evidence of necrosis to implicate Sheehans’ syndrome as the cause. The concurrence of lymphocytic hypophysitis and thyroiditis led the authors to speculate that the two diseases could be related autoimmune disorders.

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References

  1. Goudie, R., Pinkerton, P. 1962. Anterior hypophysitis and Hashimoto’s disease in a young woman. JPathol Bacteriol. 83:584–85.

    Article  CAS  Google Scholar 

  2. Feigenbaum, S.L., Martin, M.C., Wilson, C.B., Jaffe, R.B. 1991. Lymphocytic adenohypophysitis: a pituitary mass lesion occurring in pregnancy. Proposal for medical treatment. Am J Obstet Gynecol 164(6 Pt 1):1549–55.

    PubMed  CAS  Google Scholar 

  3. Abe, T., Matsumoto, K., Sanno, N., Osamura, Y. 1995. Lymphocytic hypophysitis: case report. Neurosurgery. 36(5):1016–9.

    Article  PubMed  CAS  Google Scholar 

  4. Guay, A.T., Agnello, V., Tronic, B.C., Gresham, D.G., Freidberg, S.R. 1987. Lymphocytic hypophysitis in a man. Journal of Clinical Endocrinology & Metabolism. 64(3):631–4.

    Article  CAS  Google Scholar 

  5. Lee, J.H., Laws, E.R.Jr., Guthrie, B.L., Dina, T.S., Nochomovitz, L.E. 1994. Lymphocytic hypophysitis: occurrence in two men. Neurosurgery. 34(1):159–62; discussion 162–3.

    Article  PubMed  CAS  Google Scholar 

  6. Supler, M.L., Mickle, J.P. 1992. Lymphocytic hypophysitis: report of a case in a man with cavernous sinus involvement. Surgical Neurology. 37(6):472–6.

    Article  PubMed  CAS  Google Scholar 

  7. Thodou, E., Asa, L., Kontogeorgos, G., Kovacs, K., Horvath, E., Ezzat, S. 1995. Clinical case seminar: lymphocytic hypophysitis: clinicopathological findings. Journal of Clinical Endocrinology & Metabolism. 80(8):2302–11.

    Article  CAS  Google Scholar 

  8. Jenkins, P.J., Chew, S.L., Lowe, D.G., Afshart, F., Charlesworth, M., Besser, G.M., Wass, J.A. 1995. Lymphocytic hypophysitis: unusual features of a rare disorder [see comments]. Clinical Endocrinology. 42(5):529–34.

    Article  PubMed  CAS  Google Scholar 

  9. Nussbaum, C.E., Okawara, S.H., Jacobs, L.S. 1991. Lymphocytic hypophysitis with involvement of the cavernous sinus and hypothalamus. Neurosurgery. 28(3):440–4.

    Article  PubMed  CAS  Google Scholar 

  10. McCutcheon, I.E., Oldfield, E.H. 1991. Lymphocytic adenohypophysitis presenting as infertility. Case report. JNeurosurg. 74(5):821–6.

    Article  CAS  Google Scholar 

  11. Hartmann, I., Tallen, G., Graf, K.J., Unterberg, A., Lanksch, W.R., StoltenburgDidinger, G. 1996. Lymphocytic hypophysitis simulating a pituitary adenoma in a nonpregnant woman. Clinical Neuropathology. 15(4):234–9.

    PubMed  CAS  Google Scholar 

  12. Paja, M., Estrada, J., Ojeda, A., Ramon, Y., Cajal, S., Garcia-Uria, J., Lucas, T. 1994. Lymphocytic hypophysitis causing hypopituitarism and diabetes insipidus, and associated with autoimmune thyroiditis, in a non-pregnant woman. Postgraduate Medical Journal. 70(821):220–4.

    Article  PubMed  CAS  Google Scholar 

  13. Steup-Beekman, G.M., Zweers, E.J. 1998. Lymphocytic hypophysitis in a 43-yearold woman. Netherlands Journal of Medicine. 53(2):76–9.

    Article  PubMed  CAS  Google Scholar 

  14. Wild, R.A., Kepley, M. 1986. Lymphocytic hypophysitis in a patient with amenorrhea and hyperprolactinemia. A case report. Journal of Reproductive Medicine. 31(3):211–6.

    PubMed  CAS  Google Scholar 

  15. Cosman, F., Post, K.D., Holub, D.A., Wardlaw, S.L. 1989. Lymphocytic hypophysitis. Report of 3 new cases and review of the literature. Medicine. 68(4):240–56.

    Article  PubMed  CAS  Google Scholar 

  16. Gonzalez, J.G., Elizondo, G., Saldivar, D., Nanez, H., Todd, L.E., Villarreal, J.Z. 1988. Pituitary gland growth during normal pregnancy: an in vivo study using magnetic resonance imaging. American Journal of Medicine. 85(2):217–20.

    Article  PubMed  CAS  Google Scholar 

  17. Scheithauer, B.W., Kovacs, K.T., Young, W.F. Jr., Randall, R.V. 1992. The pituitary gland in hyperthyroidism. Mayo Clinic Proceedings. 67(1):22–6.

    PubMed  CAS  Google Scholar 

  18. Shanklin, W. 1951. Lymphoid tissue in the human pituitary. Anat Rec. 111:177–91.

    Article  PubMed  CAS  Google Scholar 

  19. Asa, S.L., Bilbao, J.M., Kovacs, K., Josse, R.G., Kreines, K. 1981. Lymphocytic hypophysitis of pregnancy resulting in hypopituitarism: a distinct clinicopathologic entity. Annals of Internal Medicine. 95(2):166–71.

    PubMed  CAS  Google Scholar 

  20. Bevan, J.S., Othman, S., Lazarus, J.H., Parkes, A.B., Hall, R. 1992. Reversible adrenocorticotropin deficiency due to probable autoimmune hypophysitis in a woman with postpartum thyroiditis. Journal of Clinical Endocrinology & Metabolism. 74(3):548–52.

    Article  CAS  Google Scholar 

  21. Ishihara, T., Hino, M., Kurahachi, H., Kobayashi, H., Kajikawa, M., Moridera, K., Ikekubo, K., Hattori, N. 1996. Long-term clinical course of two cases of lymphocytic adenohypophysitis. Endocr J. 43(4):433–40.

    Article  PubMed  CAS  Google Scholar 

  22. Jensen, M.D., Handwerger, B.S., Scheithauer, B.W., Carpenter, P.C., Mirakian, R., Banks, P.M. 1986. Lymphocytic hypophysitis with isolated corticotropin deficiency. Annals of Internal Medicine. 105(2):200–3.

    PubMed  CAS  Google Scholar 

  23. Ozawa, Y., Shishiba, Y. 1993. Recovery from lymphocytic hypophysitis associated with painless thyroiditis: clinical implications of circulating antipituitary antibodies. Acta Endocrinologica. 128(6):493–8.

    PubMed  CAS  Google Scholar 

  24. Richtsmeier, A.J., Henry, R.A., Bloodworth, J.M.Jr., Ehrlich, E.N. 1980. Lymphoid hypophysitis with selective adrenocorticotropic hormone deficiency. Archives of Internal Medicine. 140(9):1243–5.

    Article  PubMed  CAS  Google Scholar 

  25. Sobrinho-Simoes, M., Brandao, A., Paiva, M.E., Vilela, B., Fernandes, E., CarneiroChaves, F. 1985. Lymphoid hypophysitis in a patient with lymphoid thyroiditis, lymphoid adrenalitis, and idiopathic retroperitoneal fibrosis. Archives of Pathology & Laboratory Medicine. 109(3):230–3.

    CAS  Google Scholar 

  26. Lack, E.E. 1975. Lymphoid “hypophysitis” with end organ insufficiency. Archives of Pathology & Laboratory Medicine. 99(4):215–9.

    CAS  Google Scholar 

  27. Hume, R., Roberts, G.H. 1967. Hypophysitis and hypopituitarism: report of a case. British Medical Journal. 2(551):548–50.

    Article  PubMed  CAS  Google Scholar 

  28. Mazzone, T., Kelly, W., Ensinck, J. 1983. Lymphocytic hypophysitis. Associated with antiparietal cell antibodies and vitamin B12 deficiency. Archives of Internal Medicine. 143(9):1794–5.

    Article  PubMed  CAS  Google Scholar 

  29. Barkan, A.L., Kelch, R.P., Marshall, J.C. 1985. Isolated gonadotrope failure in the polyglandular autoimmune syndrome. New England Journal of Medicine. 312(24):1535–40.

    Article  PubMed  CAS  Google Scholar 

  30. Kojima, I., Nejima, I., Ogata, E. 1982. Isolated adrenocorticotropin deficiency associated with polyglandular failure. J Clin Endocrinol Metab. 54(1):182–6.

    Article  PubMed  CAS  Google Scholar 

  31. Muir, A., Maclaren, N.K. 1991. Autoimmune diseases of the adrenal glands, parathyroid glands, gonads, and hypothalamic-pituitary axis. Endocrinol Metab Clin North Am. 20(3):619–44.

    PubMed  CAS  Google Scholar 

  32. Bottazzo, G.F., Pouplard, A., Florin-Christensen, A., Doniach, D. 1975. Autoantibodies to prolactin-secreting cells of human pituitary. Lancet. 2(7925):97–101.

    Article  PubMed  CAS  Google Scholar 

  33. Castle, D., de Villiers, J.C., Melvill, R. 1988. Lymphocytic adenohypophysitis. Report of a case with demonstration of spontaneous tumour regression and a review of the literature. Br J Neurosurg. 2(3):401–5.

    Article  PubMed  CAS  Google Scholar 

  34. Levine, S. 1967. Allergic adenohypophysitis: new experimental disease of the pituitary gland. Science. 158(805):1190–1.

    Article  PubMed  CAS  Google Scholar 

  35. Levine, S. 1969. Allergic adrenalitis and adenohypophysitis: further observations on production and passive transfer. Endocrinology. 84(3):469–75.

    Article  PubMed  CAS  Google Scholar 

  36. Klein, I., Kraus, K.E., Martines, A.J., Weber, S. 1982. Evidence for cellular mediated immunity in an animal model of autoimmune pituitary disease. Endocr Res Commun. 9(2):145–53.

    Article  PubMed  CAS  Google Scholar 

  37. Yoon, J.W., Choi, D.S., Liang, H.C., Back, H.S., Ko, I.Y., Jun, H.S., Gillam, S. 1992. Induction of an organ-specific autoimmune disease, lymphocytic hypophysitis, in hamsters by recombinant rubella virus glycoprotein and prevention of disease by neonatal thymectomy. Journal of Virology. 66(2):1210–4.

    PubMed  CAS  Google Scholar 

  38. Mayfield, R.K., Levine, J.H., Gordon, L., Powers, J., Galbraith, R.M., Rawe, S.E. 1980. Lymphoid adenohypophysitis presenting as a pituitary tumor. Am J Med. 69(4):619–23.

    PubMed  CAS  Google Scholar 

  39. Bottazzo, G.F., Doniach, D. 1978. Pituitary autoimmunity: a review. J R Soc Med. 71(6):433–6.

    PubMed  CAS  Google Scholar 

  40. Bottazzo, G.F., McIntosh, C., Stanford, W., Preece, M. 1980. Growth hormone cell antibodies and partial growth hormone deficiency in a girl with Turner’s syndrome. Clin Endocrinol (Oxf). 12(1):1–9.

    Article  CAS  Google Scholar 

  41. Crock, P., Salvi, M., Miller, A., Wall, J., Guyda, H. 1993. Detection of anti-pituitary autoantibodies by immunoblotting. Jlmmunol Methods. 162(1):31–40.

    Article  CAS  Google Scholar 

  42. Crock, P.A. 1998. Cytosolic autoantigens in lymphocytic hypophysitis. Journal of Clinical Endocrinology & Metabolism. 83(2):609–18.

    Article  CAS  Google Scholar 

  43. Komatsu, M., Kondo, T., Yamauchi, K., Yokokawa, N., Ichikawa, K., Ishihara, M., Aizawa, T., Yamada, T., Imai, Y., Tanaka, K and others. 1988. Antipituitary antibodies in patients with the primary empty sella syndrome. J Clin Endocrinol Metab. 67(4):633–8.

    Article  PubMed  CAS  Google Scholar 

  44. Scherbaum, W.A., Schrell, U., Gluck, M., Fahlbusch, R., Pfeiffer, E.F. 1987. Autoantibodies to pituitary corticotropin-producing cells: possible marker for unfavourable outcome after pituitary microsurgery for Cushing’s disease. Lancet. 1 (8547):1394–8.

    Article  PubMed  CAS  Google Scholar 

  45. Engelberth, O., Jezkova, Z., Bleha, O., Malek, J., Bendl, J. 1965. [Autoantibodies in Sheehan’s syndrome]. Vnitr Lek. 11(8):737–41.

    PubMed  CAS  Google Scholar 

  46. Powrie, J.K., Powell, M., Ayers, A.B., Lowy, C., Sonksen, P.H. 1995. Lymphocytic adenohypophysitis: magnetic resonance imaging features of two new cases and a review of the literature. Clin Endocrinol (Oxf);42(3):315–22.

    Article  CAS  Google Scholar 

  47. Beressi, N., Beressi, J.P., Cohen, R., Modigliani, E. 1999. Lymphocytic hypophysitis. A review of 145 cases. Annales de Medecine Interne. 150(4):327–41.

    PubMed  CAS  Google Scholar 

  48. Vanneste, J.A., Kamphorst, W. 1987. Lymphocytic hypophysitis. Surgical Neurology. 28(2):145–9.

    Article  PubMed  CAS  Google Scholar 

  49. Ikeda, J., Kuratsu, J., Miura, M., Kai, Y., Ushio, Y. 1990. Lymphocytic adenohypophysitis accompanying occlusion of bilateral internal carotid arteries--case report. Neurol Med Chir (Tokyo). 30(5):346–9.

    Article  CAS  Google Scholar 

  50. Burke, C.W., Moore, R.A., Rees, L.H., Bottazzo, G.F., Mashiter, K., Bitensky, L. 1979. Isolated ACTH deficiency and TSH deficiency in the adult. J R Soc Med. 72(5):328–35.

    PubMed  CAS  Google Scholar 

  51. Goluboff, L.G., Ezrin, C. 1969. Effect of pregnancy on the somatotroph and the prolactin cell of the human adenohypophysis. J Clin Endocrinol Metab. 29(12):1533–8.

    Article  PubMed  CAS  Google Scholar 

  52. Masana, Y., Ikeda, H., Fujimoto, Y., Matsumura, I., Kawakami, F., Mori, S., Arita, N., Ushio, Y. 1990. [Lymphocytic adenohypophysitis. Case report]. Neurol Med Chir (Tokyo). 30(11):853–7.

    Article  CAS  Google Scholar 

  53. McConnon, J.K., Smyth, H.S., Horvath, E. 1991. A case of sparsely granulated growth hormone cell adenoma associated with lymphocytic hypophysitis. Journal of Endocrinological Investigation. 14(8):691–6.

    PubMed  CAS  Google Scholar 

  54. Cebelin, M.S., Velasco, M.E., de las Mulas, J.M., Druet, R.L. 1981. Galactorrhea associated with lymphocytic adenohypophysitis. Case report. Br J Obstet Gynaecol. 88(6):675–80.

    Article  PubMed  CAS  Google Scholar 

  55. Portocarrero, C.J., Robinson, A.G., Taylor, A.L., Klein, I. 1981. Lymphoid hypophysitis. An unusual cause of hyperprolactinemia and enlarged sella turcica. JAMA. 246(16):1811–2.

    Article  PubMed  CAS  Google Scholar 

  56. Lees, P.D., Pickard, J.D. 1987. Hyperprolactinemia, intrasellar pituitary tissue pressure, and the pituitary stalk compression syndrome. JNeurosurg. 67(2):192–6.

    Article  CAS  Google Scholar 

  57. Pressman, E.K., Zeidman, S.M., Reddy, U.M., Epstein, J.I., Brem, H. 1995. Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient. J Reprod Med. 40(4):251–9.

    PubMed  CAS  Google Scholar 

  58. Saiwai, S., Inoue, Y., Ishihara, T., Matsumoto, S., Nemoto, Y., Tashiro, T., Hakuba, A., Miyamoto, T. 1998. Lymphocytic adenohypophysitis: skull radiographs and MRI. Neuroradiology. 40(2):114–20.

    Article  PubMed  CAS  Google Scholar 

  59. Ahmadi, J., Meyers, G.S., Segall, H.D., Sharma, O.P., Hinton, D.R. 1995. Lymphocytic adenohypophysitis: contrast-enhanced MR imaging in five cases. Radiology. 195(1):30–4.

    PubMed  CAS  Google Scholar 

  60. Prasad, A., Madan, V.S., Sethi, P.K., Prasad, M.L., Buxi, T.B., Kanwar, C.K. 1991. Lymphocytic hypophysitis: can open exploration of the sella be avoided? British Journal of Neurosurgery. 5(6):639–42.

    Article  PubMed  CAS  Google Scholar 

  61. Divers, W.A.Jr., Yen, S.S. 1983. Prolactin-producing microadenomas in pregnancy. Obstet Gynecol. 62(4):425–9.

    PubMed  Google Scholar 

  62. Molitch, M.E. 1985. Pregnancy and the hyperprolactinemic woman. N Engl J Med. 312(21):1364–70.

    Article  PubMed  CAS  Google Scholar 

  63. Molitch, M.E. 1997. Pituitary incidentalomas. Endocrino! Metab Clin North Am. 26(4):725–40.

    Article  CAS  Google Scholar 

  64. Heinze, H.J., Bercu, B.B. 1997. Acquired hypophysitis in adolescence. Journal of Pediatric Endocrinology & Metabolism. 10(3):315–21.

    Article  CAS  Google Scholar 

  65. Miyamoto, M., Sugawa, H., Mori, T., Hashimoto, N., Imura, H. 1988. A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis. Endocrinol J pn;35(4):607–16.

    CAS  Google Scholar 

  66. Honegger, J., Fahlbusch, R., Bornemann, A., Hensen, J., Buchfelder, M., Muller, M., Nomikos, P. 1997. Lymphocytic and granulomatous hypophysitis: experience with nine cases [see comments]. Neurosurgery. 40(4):713–22; discussion 722–3.

    Article  PubMed  CAS  Google Scholar 

  67. Nishioka, H., Ito, H., Sano, T., Ito, Y. 1996. Two cases of lymphocytic hypophysitis presenting with diabetes insipidus: a variant of lymphocytic infundibuloneurohypophysitis. Surgical Neurology. 46(3):285–90; discussion 290–1.

    Article  PubMed  CAS  Google Scholar 

  68. Imura, H., Nakao, K., Shimatsu, A., Ogawa, Y., Sando, T., Fujisawa, I., Yamabe, H. 1993. Lymphocytic infundibuloneurohypophysitis as a cause of central diabetes insipidus. N Eng! J Med. 329(10):683–9.

    Article  CAS  Google Scholar 

  69. Reusch, J.E., Kleinschmidt-DeMasters, B.K., Lillehei, K.O., Rappe, D., Gutierrez-Hartmann, A. 1992. Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamethasone: case report. Neurosurgery. 30(2):268–72.

    Article  PubMed  CAS  Google Scholar 

  70. Pestell R.G., Best J.D., Alford F.P. 1990. Lymphocytic hypophysitis. The clinical spectrum of the disorder and evidence for an autoimmune pathogenesis [see comments]. Clinical Endocrinolog. 33(4):457–66.

    CAS  Google Scholar 

  71. Nishioka, H., Ito, H., Fukushima, C. 1997. Recurrent lymphocytic hypophysitis: case report. Neurosurgery. 41(3):684–6; discussion 686–7.

    PubMed  CAS  Google Scholar 

  72. Zeller, J.R, Cerletty, J.M., Rabinovitch, R.A., Daniels, D. 1982. Spontaneous regression of a postpartum pituitary mass demonstrated by computed tomography. Arch Intern Med. 142(2):373–4.

    Article  PubMed  CAS  Google Scholar 

  73. Leiba, S., Schindel, B., Weinstein, R., Lidor, I., Friedman, S., Matz, S. 1986. Spontaneous postpartum regression of pituitary mass with return of function. Jama. 255(2):230–2.

    Article  PubMed  CAS  Google Scholar 

  74. Bitton, R.N., Slavin, M., Decker, R.E., Zito, J., Schneider, B.S. 1991. The course of lymphocytic hypophysitis [see comments]. Surgical Neurology. 36(1):40–3.

    Article  PubMed  CAS  Google Scholar 

  75. Stelmach, M., O’Day, J. 1991. Rapid change in visual fields associated with suprasellar lymphocytic hypophysitis. Journal of Clinical Neuro-Ophthalmology. 11(1):19–24.

    Article  PubMed  CAS  Google Scholar 

  76. Kristof, R.A., Van Roost, D., Klingmuller, D., Springer, W., Schramm J. 1999. Lymphocytic hypophysitis: non-invasive diagnosis and treatment by high dose methylprednisolone pulse therapy? Journal of Neurology, Neurosurgery & Psychiatry. 67(3):398–402.

    Article  CAS  Google Scholar 

  77. Tsur, A., Leibowitz, G., Samueloff, A., Gross, D.J. 1996. Successful pregnancy in a patient with pre-existing lymphocytic hypophysitis. Acta Obstetricia et Gynecologica Scandinavica. 75(8):772–4.

    Article  PubMed  CAS  Google Scholar 

  78. Nishioka, H., Ito, H., Miki, T., Akada, K. 1994. A case of lymphocytic hypophysitis with massive fibrosis and the role of surgical intervention. Surgical Neurology. 42(1):74–8.

    Article  PubMed  CAS  Google Scholar 

  79. Parent, A.D. 1992. The course of lymphocytic hypophysitis [letter; comment]. Surgical Neurology. 37(1):71.

    Article  PubMed  CAS  Google Scholar 

  80. Beressi, N., Cohen, R., Beressi, J.P., Dumas, J.L., Legrand, M., Iba-Zizen, M.T. 1994. Modigliani E. Pseudotumoral lymphocytic hypophysitis successfully treated by corticosteroid alone: first case report. Neurosurgery.35(3):505–8; discussion 508.

    Article  PubMed  CAS  Google Scholar 

  81. Gagneja, H., Arafah, B., Taylor, H.C. 1999. Histologically proven lymphocytic hypophysitis: spontaneous resolution and subsequent pregnancy. Mayo Clinic Proceedings. 74(2):150–4.

    Article  PubMed  CAS  Google Scholar 

  82. McDermott, M.W., Griesdale, D.E., Berry, K., Wilkins, E. 1988. Lymphocytic adenohypophysitis. Can J Neurol Sci. 15(1):38–43.

    PubMed  CAS  Google Scholar 

  83. Ikeda, H., Okudaira, Y. 1987. Spontaneous regression of pituitary mass in temporal association with pregnancy. Neuroradiology. 29(5):488–92.

    Article  PubMed  CAS  Google Scholar 

  84. Grimes, H.G., Brooks, M.H. 1980. Pregnancy in Sheehan’s syndrome. Report of a case and review. Obstet Gynecol Surv. 35(8):481–8.

    Article  PubMed  CAS  Google Scholar 

  85. Verdu, L.I., Martin-Caballero, C., Garcia-Lopez, G., Cueto, M.J. 1998. Ovulation induction and normal pregnancy after panhypopituitarism due to lymphocytic hypophysitis. Obstetrics & Gynecology. 91(5 Pt 2):850–2.

    Article  CAS  Google Scholar 

  86. Nishioka, H., Ito, H., Haraoka, J., Takahashi, M., Shinmura, F. 1998. Idiopathic hypertrophie cranial pachymeningitis of the cavernous sinus mimicking lymphocytic hypophysitis. Neurol Med Chir (Tokyo) 38(6):377–82

    Article  CAS  Google Scholar 

  87. Van Havenbergh, T., Robberecht, W., Wilms, G., Van Calenbergh, F., Goffin, J., Dom, R., Bouillon, R., Plets, C. 1996. Lymphocytic infundibulohypophysitis presenting in the postpartum period: case report. Surg Neurol 46 (3):280–4

    Article  PubMed  Google Scholar 

  88. Kojima, H., Nojima, T., Nagashima, K., Ono, Y., Kudo, M., Ishikura, M. 1989. Diabetes insipidus caused by lymphocytic infundibuloneurohypophysitis. Arch Pathol Lab Med 113(l2):1399–401

    PubMed  CAS  Google Scholar 

  89. Shimono, T., Yamaoka, T., Nishimura, K., Koshiyama, H., Sakamoto, M., Koh, T., Hayakawa, K. 1999. Lymphocytic hypophysitis presenting with diabetes insipidus: MR findings. Eur Radio! 9(7):1397–400

    Article  CAS  Google Scholar 

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  1. Metabolism, and Molecular Medicine, Northwestern University Medical School Center for Endocrinology, Chicago, Illinois, 60611

    Mary P. Gillam & Mark E. Molitch

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  1. Hospital das Clinicas, University of SĂŁo Paulo Medical School, Brazil

    Marcello D. Bronstein

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Gillam, M.P., Molitch, M.E. (2001). Lymphocytic Hypophysitis. In: Bronstein, M.D. (eds) Pituitary Tumors in Pregnancy. Endocrine Updates, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1435-0_7

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