Abstract
Extracellular signal transduction pathways in blood are often composed of cascades of serine proteinases to amplify rapidly a response to wounding or infection. The vertebrate blood coagulation and complement pathways are the most fully characterized of such proteinase cascades. Serine proteinases also play important roles in defensive responses in hemolymph of arthropods. The hemolymph coagulation system of horseshoe crabs has been very nicely elucidated to function as a complex and intricately regulated proteinase cascade for protection against microbial infection (Kawabata et al., 1996).
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Kanost, M.R., Jiang, H., Wang, Y., Yu, XQ., Ma, C., Zhu, Y. (2001). Hemolymph Proteinases in Immune Responses of Manduca sexta. In: Beck, G., Sugumaran, M., Cooper, E.L. (eds) Phylogenetic Perspectives on the Vertebrate Immune System. Advances in Experimental Medicine and Biology, vol 484. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1291-2_32
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DOI: https://doi.org/10.1007/978-1-4615-1291-2_32
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