Skip to main content

Risk Factors for Candida infections in the Intensive Care Unit

European Perspective

  • Chapter

Part of the book series: Perspectives on Critical Care Infectious Diseases ((CCID,volume 6))

Abstract

Critically-ill patients are at risk of invasive fungal infections. Recent epidemiological surveys suggest that mycotic diseases represent one of the most rapidly growing infectious complications in the intensive care unit (ICU) setting.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Vincent JL, Anaissie E, Bruining Het al.Epidemiology, diagnosis and treatment of systemic Candida infection in surgical patients under intensive care. Intensive Care Med 1998;24:206–16.

    Article  PubMed  CAS  Google Scholar 

  2. Fraser VJ, Jones M, Dunkel Jet al.Candidemia in a tertiary care hospital: epidemiology, risk factors, and predictors of mortality. Clin Infect Dis 1992;15:414–21.

    Article  PubMed  CAS  Google Scholar 

  3. Jantunen E, Ruutu P, Niskanen Let al.Incidence and risk factors for invasive fungal infections in allogeneic BMT recipients. Bone Marrow Transplant 1997;19:801–8.

    Article  PubMed  CAS  Google Scholar 

  4. Collins LA, Samore MH, Roberts MSet al.Risk factors for invasive fungal infections complicating othotopic liver transplantation. J Infect Dis 1994;170:644–52.

    Article  CAS  Google Scholar 

  5. Huang YC, Li CC, Lin TYet al.Association of fungal colonization and invasive disease in very low birth weight infants. Pediatr Infect Dis J 1998;17:819–22.

    Article  PubMed  CAS  Google Scholar 

  6. Petri MG, Konig J, Moecke HPetal. Epidemiology of invasive mycosis in ICU patients: a prospective multicenter study in 435 non-neutropenic patients. Intensive Care Med 1997; 3:317–25.

    Article  Google Scholar 

  7. Calandra T, Bille J, Schneider R, Mossiman F, Francoli P. Clinical significance ofCandidaisolated from the peritoneum in surgical patients. Lancet 1989; ii;1437–40.

    Article  Google Scholar 

  8. Voss A, Hollis RJ, Pfaller MA, Wenzel RP, Doebbeling BN. Investigation of the sequence of colonization and candidemia in nonneutropenic patients. J Clin Microbiol 1994;32:975–80.

    PubMed  CAS  Google Scholar 

  9. Garbino J, Pittet D. Candida infections in the ICU. Clin Intensive Care 1997;8:187–200.

    Google Scholar 

  10. Pittet D, Monod M, Suter PM, Frenk E, Auckenthaler R. Candida colonization and subsequent infections in critically ill surgical patients. Ann Surg 1994;220:751–8.

    Article  PubMed  CAS  Google Scholar 

  11. Van Saene HKF, Damjanovic V, Pizer B, Petros AJ. Fungal infections in ICU J Hosp Infect 1999;41:337–8.

    Google Scholar 

  12. Sobel JD, Kauffman CA, McKinsey Det al.Candiduria: a randomized, double-blind study of treatment with fluconazole and placebo. Clin Infect Dis 2000;30:19–24.

    Article  PubMed  CAS  Google Scholar 

  13. Kauffman CA, Vazquez JA, Sobel JDet al.Prospective multicenter surveillance study of funguria in hospitalized patients. Clin Infect Dis 2000;30:14–8.

    Article  PubMed  CAS  Google Scholar 

  14. Ayeni O, Riederer KM, Wilson FM, Khatib R. Clinicians’reaction to positive urine culture forCandidaorganisms. Mycoses 1999;42;285–9.

    Article  PubMed  CAS  Google Scholar 

  15. Bauer TT, Torres A. Candida pneumonia. Clin Intensive Care 1999;10:33–9.

    Google Scholar 

  16. Munoz P, Burillo A, Bouza E. Criteria used when initiating antifungal therapy againstCandidaspecies in the intensive care unit. Int J Antimicrob Agents 2000;15:83–90.

    Article  PubMed  CAS  Google Scholar 

  17. Flanagan PG, Barnes RA. Fungal infections in the intensive care unit. J Hosp Infect 1998;38:163–77.

    Article  PubMed  CAS  Google Scholar 

  18. Alverdy JC, Ayos E, Moss GS. Total parenteral nutrition promotes bacterial translocation from the gut. Surgery 1988;104:185–90.

    PubMed  CAS  Google Scholar 

  19. Windsor AJC, Kanwar S, Li AJKet al.Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis. Gut 1998;42:431–5.

    Article  PubMed  CAS  Google Scholar 

  20. Kox WJ, Volk T, Kox SN, Volk H-D. Immunomodulatory therapy in sepsis. Intensive Care Med 2000;26:S124–8.

    Article  PubMed  Google Scholar 

  21. Romani L. Innate and adaptive immunity inCandida albicansinfections and saprophytism J Leuc Biol 2000;68:175–9.

    Google Scholar 

  22. Mencacci A, Cenci E, Bacci Aet al.Host immune reactivity determines the efficacy of combination immunotherapy and antifungal chemotherapy in candidiasis. J Infect Dis 2000;181;686–94

    Article  PubMed  CAS  Google Scholar 

  23. Romani L. Host immune reactivity and antifungal chemotherapy: the power of being together. J Chemother 2001;13:347–53.

    PubMed  CAS  Google Scholar 

  24. Rex JH, Sobel JD. Preventing intra-abdominal candidiasis in surgical patients. Crit Care Med 1999:27:1033–4.

    Article  PubMed  CAS  Google Scholar 

  25. Eggimann P, Francioli P, Bille Jet al.Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients. Crit Care Med 1999:27:1066–72.

    Article  PubMed  CAS  Google Scholar 

  26. Grewe M, Tsiotos GG, de-Leon EL, Sarr MG. Fungal infection in acute necrotizing pancreatitis. J Am Coll Surg 1999;188:408–14.

    Article  PubMed  CAS  Google Scholar 

  27. Beger HG, Bittner R, Block S, Buchler M. Bacterial contamination of pancreatic necrosis: a prospective clinical study. Gastroenterology 1986;91:433–8.

    PubMed  CAS  Google Scholar 

  28. Bassi C. Infected pancreatic necrosis. Int J Pancreatol 1994;16:1–10.

    PubMed  CAS  Google Scholar 

  29. Gotzinger P, Wamser P, Barlan Met al.Candida infection of local necrosis in severe acute pancreatitis is associated with increased mortality. Shock 2000;14:320–3.

    Article  PubMed  CAS  Google Scholar 

  30. Hennequin C. Endogenous candidal peritonitis. J Mycol Med 2000;10:21–6.

    Google Scholar 

  31. Hoerauf A, Hammer S, Muller-Myhsok B, Rupprecht H. Intra-abdominal Candida infection during acute necrotizing pancreatitis has a high prevalence and is associated with increased mortality. Crit Care Med 1998;26:2010–5.

    Article  PubMed  CAS  Google Scholar 

  32. Gotzinger P, Sautner T, Spittler A. Severe acute pancreatitis causes alterations in HLADR and CD 14 expression on peripheral blood monocytes independently of surgical treatment. Eur J Surg 2000;166:628–32.

    Article  PubMed  CAS  Google Scholar 

  33. Butturini G, Salvia R, Bettini Ret al.Infection prophylaxis in necrotising pancreatitis: an old challenge with new perspectives. J Hosp Infect 2001;49:4–8.

    Article  PubMed  CAS  Google Scholar 

  34. Shrikhande S, Friess H, Issenegger Cet al.Fluconazole penetration into the pancreas. Antimicrob Agents Chemother 2000;44:2569–71.

    Article  PubMed  CAS  Google Scholar 

  35. Bassi C, Falconi M, Talamini Get al.Controlled clinical trial of perfloxacin versus imipenem in severe acute pancreatitis. Gastroenterology 1998;115:1513–7.

    Article  PubMed  CAS  Google Scholar 

  36. Saiman L, Ludington E, Pfaller Met al.Risk factors for candidemia in neonatal intensive care unit patients. Pediatr Infect Dis J 2000;19:319–24.

    Article  PubMed  CAS  Google Scholar 

  37. Bryant K, Maxfield C, Rabalais G. Renal candidiasis in neonates with candiduria. Pediatr Infect Dis J 1999;18:959–63.

    Article  PubMed  CAS  Google Scholar 

  38. Eubanks Pi, Devirgilio C, Klein S, Bongard F. Candida sepsis in surgical patients. Am J Surg 1993;166:617–20.

    Article  Google Scholar 

  39. Blot S, Vandewoude K, Hoste E, Poelaert J, Colardyn F. Outcome in critically ill patients with candidal fungaemia:Candida albicansvs.Candida glabrata.J Hosp Infect 2001;47:308–13.

    Article  PubMed  CAS  Google Scholar 

  40. Ensari C, Ekim M, Ikinciogullari A, Turner N, Ensari A. Are uraemic children immunologically compromised? Nephron 2001;88:379–81.

    Article  PubMed  CAS  Google Scholar 

  41. Heidenreich S, Schmidt M, Bachmann J, Harrach B. Apoptosis of monocytes cultured from long-term hemodialysis patients. Kidney Internat 1996;49:792–9.

    Article  CAS  Google Scholar 

  42. DiScipio AW, Burchard KW. Continuous arteriovenous hemofiltration attenuates polymorphonuclear leukocyte phagocytosis in porcine intra-abdominal sepsis. Am J Surg 1997;173:174–80.

    Article  PubMed  CAS  Google Scholar 

  43. Rolando N, Harvey F, Brahm Jet al.Fungal infection: a common, unrecognized complication of acute liver-failure. J Hepatol 1991;12:1–9.

    Article  PubMed  CAS  Google Scholar 

  44. Bauer TM, Dupont V, Zimmerli W. Invasive candidiasis complicating spontaneous esophageal perforation (Boerhaave syndrome). Am J Gastroenterol 1996;91:1248–50.

    PubMed  CAS  Google Scholar 

  45. van Saene HKF, Damjanovic V, Pizer B, Petros AJ. Fungal infections in ICU. J Hosp Infect 1999;41:337–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Science+Business Media New York

About this chapter

Cite this chapter

Barnes, R.A. (2002). Risk Factors for Candida infections in the Intensive Care Unit. In: Barnes, R.A., Warnock, D.W. (eds) Fungal Infection in the Intensive Care Unit. Perspectives on Critical Care Infectious Diseases, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0977-6_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0977-6_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5333-1

  • Online ISBN: 978-1-4615-0977-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics