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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

Volume 507 of the series Advances in Experimental Medicine and Biology pp 123-126

Expression Of Cycloxygenase-2 In Human Bladder And Renal Cell Carcinoma

  • Shuntaro HaraAffiliated withSchool of Pharmaceutical Sciences, Kitasato University
  • , Yukihiro KondoAffiliated withNippon Medical School, Kitasato University
  • , Ichiro MatsuzawaAffiliated withNippon Medical School, Kitasato University
  • , Yoshitaka HashimotoAffiliated withNippon Medical School, Kitasato University
  • , Go KimuraAffiliated withNippon Medical School, Kitasato University
  • , Masaso AkimotoAffiliated withNippon Medical School, Kitasato University
  • , Nobumasa ImuraAffiliated withSchool of Pharmaceutical Sciences, Kitasato University

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Abstract

Cyclooxygenase (COX) catalyses the synthesis of prostaglandins from arachidonic acid. There are two isoforms of COX (DuBois et al., 1998; vane et al., 1998). One is constitutively expressed (COX-1) and the other is inducible (COX-2). The COX-2 gene is an immediate, early-response gene that is induced by growth factors, oncogenes, carcinogens, and tumor-promoting phorbol esters (Inoue et al., 1995; Nanayama et al., 1995; Herschman, 1996). The constitutive isoform, COX-1, is essentially unaffected by these factors.