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Periodontitis and Liver Diseases

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Studies on Periodontal Disease

Abstract

Periodontitis, which is a chronic inflammatory disease caused by oral bacterial infection, is considered to be a risk factor for systemic disease. The liver is an important organ closely associated with lipid and glucose metabolism. Non-alcoholic fatty liver disease (NAFLD) is a major chronic liver disease. In this chapter, the relationship between periodontitis and liver diseases, focusing mainly on NAFLD progression, is summarized. Periodontitis increases the serum lipopolysaccharide level, contributing to liver injury. In addition, clinical and animal studies have shown that periodontal inflammation induces overproduction of lipid peroxide in the periodontal lesion, which is involved in progression of liver diseases. That liver abnormalities may indicate a risk for periodontitis and that periodontitis may be a risk factor for the progression of liver diseases are discussed.

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Authors and Affiliations

  1. Department of Preventive Dentistry and Dental Public Health, Aichi-Gakuin University, 1-100, Kusumoto-cho, Chikusa-ku, Nagoya, 464-8650, Japan

    Koichiro Irie, Daisuke Ekuni, Takaaki Tomofuji & Manabu Morita

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  1. Koichiro Irie
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  2. Daisuke Ekuni
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  3. Takaaki Tomofuji
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  4. Manabu Morita
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Correspondence to Koichiro Irie .

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Editors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine and Pharmaceutical Sciences, Okayama, Japan

    Daisuke Ekuni

  2. Dept of Science and Clinical Specialty Odontostomatology & Biochemistry, Polytechnical University of Marche Faculty of Medicine, Ancona, Italy

    Maurizio Battino

  3. Department of Preventive Dentistry, Okayama Univ Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Takaaki Tomofuji

  4. Dept of Oral Biological & Medical Scienc Laboratory of Periodontal Biology, University of British Columbia Faculty of Dentistry, Vancouver, British Columbia, Canada

    Edward E. Putnins

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Irie, K., Ekuni, D., Tomofuji, T., Morita, M. (2014). Periodontitis and Liver Diseases. In: Ekuni, D., Battino, M., Tomofuji, T., Putnins, E. (eds) Studies on Periodontal Disease. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9557-4_14

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