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Effects of Periodontal Therapy on Circulating Oxidative Stress

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Studies on Periodontal Disease

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Abstract

Periodontitis is a chronic inflammatory disease characterized by oral bacterial infection that can lead to tooth loss in adults. In the periodontal tissue, host cells produce reactive oxygen species (ROS) as the initial defense against bacterial pathogens. However, when periodontitis develops, ROS produced in the periodontal lesion diffuse into the bloodstream, which alters the oxidative/anti-oxidative balance (oxidative stress) in blood, and this may damage multiple organs. Thus, systemic increases in oxidative stress following periodontitis are detrimental to systemic health. Furthermore, studies have demonstrated that periodontal therapy decreases oxidative stress within the oral cavity. Therefore, it is possible that periodontal therapy offers beneficial effects on both periodontal and systemic health by decreasing oxidative stress. In this chapter, we summarize the effects of periodontal therapy on circulating oxidative stress levels. We also discuss the possibility of periodontal therapy decreasing the risk of systemic diseases in periodontitis patients.

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Acknowledgments

This work was supported by Grants-in-Aid for Scientific Research (24593153) from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan.

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Authors and Affiliations

  1. Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Takaaki Tomofuji, Daisuke Ekuni & Manabu Morita

Authors
  1. Takaaki Tomofuji
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  2. Daisuke Ekuni
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  3. Manabu Morita
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Correspondence to Takaaki Tomofuji .

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Editors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine and Pharmaceutical Sciences, Okayama, Japan

    Daisuke Ekuni

  2. Dept of Science and Clinical Specialty Odontostomatology & Biochemistry, Polytechnical University of Marche Faculty of Medicine, Ancona, Italy

    Maurizio Battino

  3. Department of Preventive Dentistry, Okayama Univ Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Takaaki Tomofuji

  4. Dept of Oral Biological & Medical Scienc Laboratory of Periodontal Biology, University of British Columbia Faculty of Dentistry, Vancouver, British Columbia, Canada

    Edward E. Putnins

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Tomofuji, T., Ekuni, D., Morita, M. (2014). Effects of Periodontal Therapy on Circulating Oxidative Stress. In: Ekuni, D., Battino, M., Tomofuji, T., Putnins, E. (eds) Studies on Periodontal Disease. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9557-4_10

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