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Chemotherapy

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Pediatric Head and Neck Tumors

Abstract

Treatment of pediatric head and neck tumors requires a multimodal approach, with integration of surgical specialties, radiation therapy, pediatric oncology, and supportive care. For benign and low-grade tumors, local control with surgery is the treatment of choice, and conservative approaches that minimize disfiguration and protect function are the cornerstone of their management. However, high-grade malignancies require a more aggressive approach in order to guarantee complete local control; moreover, most pediatric cancer patients are considered to have micrometastatic disease at the time of diagnosis. For those reasons, chemotherapy is a key element in the management of pediatric head and neck malignancies.

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References

  1. Widemann BC, Adamson PC. Fundamentals of cancer chemotherapy. In: Carroll WL, Finlay JL, editors. Cancer in children and adolescents. Boston: Jones and Bartlett; 2010. pp. 95–112.

    Google Scholar 

  2. Yu AL, Gilman AL, Ozkaynak MF, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363:1324–34.

    Article  PubMed  CAS  Google Scholar 

  3. Pappo AS, Patel SR, Crowley J, et al. R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II sarcoma alliance for research through collaboration study. J Clin Oncol. 2011;29:4541–7.

    Article  PubMed  CAS  Google Scholar 

  4. Hodi FS, O’Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711–23.

    Article  PubMed  CAS  Google Scholar 

  5. Carpenter EL, Mosse YP. Targeting ALK in neuroblastoma-preclinical and clinical advancements. Nat Rev Clin Oncol. 2012;9:391–9.

    Article  PubMed  CAS  Google Scholar 

  6. Gild ML, Bullock M, Robinson BG, Clifton-Bligh R. Multikinase inhibitors: a new option for the treatment of thyroid cancer. Nat Rev Endocrinol. 2011;7:617–24.

    Article  PubMed  CAS  Google Scholar 

  7. Bollag G, Tsai J, Zhang J, et al. Vemurafenib: the first drug approved for BRAF-mutant cancer. Nat Rev Drug Discov. 2012;11:873–86.

    Article  PubMed  CAS  Google Scholar 

  8. Haidar C, Jeha S. Drug interactions in childhood cancer. Lancet Oncol. 2011;12:92–9.

    Article  PubMed  CAS  Google Scholar 

  9. Kremer LCM, Mulder RL, Oeffinger KC, et al. A worldwide collaboration to harmonize guidelines for the long-term follow-up of childhood and young adult cancer survivors: a report from the international late effects of Childhood Cancer Guideline Harmonization Group. Pediatr Blood Cancer. 2013;60:543–9.

    Article  PubMed  Google Scholar 

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Correspondence to Carlos Rodriguez-Galindo MD .

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Rodriguez-Galindo, C. (2014). Chemotherapy. In: Rahbar, R., Rodriguez-Galindo, C., Meara, J., Smith, E., Perez-Atayde, A. (eds) Pediatric Head and Neck Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8755-5_3

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  • DOI: https://doi.org/10.1007/978-1-4614-8755-5_3

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8754-8

  • Online ISBN: 978-1-4614-8755-5

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