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Celiac Disease pp 209–243Cite as

Morbidity and Mortality Associated with Celiac Disease

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Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Since celiac disease (CD) is common, with a serological prevalence of about 1 % in the Western world, comorbidity will occur by chance, as associations or as complications. Recent epidemiological studies designed to address the frequency of these occurrences have tried to minimize problems with earlier investigations which have been limited by factors such as the source and number of patients considered, choice of control groups, and ascertainment bias. Autoimmune diseases constitute clinically important associations, of which type 1 diabetes mellitus and thyroid disorders are the best studied. The frequency of malignant complications is lower than earlier studies have indicated, with lymphoma increased about fivefold. The absolute number of tumors is small. The increase in fracture risk is modest. Neurological and psychiatric conditions occur, but no disorder specifically associated with CD has been identified. Infertility associated with CD has been overexaggerated. It is important that comorbidities are identified; otherwise, symptoms may be falsely attributed to CD in relapse rather than prompt a search for another diagnosis. Furthermore, in a patient with an established diagnosis that appears to account for the whole clinical picture, CD may be overlooked.

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Authors and Affiliations

  1. Nottingham Digestive Diseases Centre, Queen’s Medical Centre, Nottingham University Hospital, Nottingham, Nottinghamshire, UK

    Nina Ruth Lewis B.Med. Sci, B.M.B.S., M.R.C.P., M.Sc., Ph.D.

  2. Department of Gastroenterology, Royal Derby Hospital, Uttoxeter Road, Derby, Derbyshire, DE22 3NE, UK

    Geoffrey K. T. Holmes M.D., Ph.D., F.R.C.P.

  3. 25 Whitaker Road, Derby, Derbyshire, DE23 6AQ, UK

    Geoffrey K. T. Holmes M.D., Ph.D., F.R.C.P.

Authors
  1. Nina Ruth Lewis B.Med. Sci, B.M.B.S., M.R.C.P., M.Sc., Ph.D.
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  2. Geoffrey K. T. Holmes M.D., Ph.D., F.R.C.P.
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Correspondence to Geoffrey K. T. Holmes M.D., Ph.D., F.R.C.P. .

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Editors and Affiliations

  1. Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

    S. Devi Rampertab

  2. Department of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerard E. Mullin

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Lewis, N.R., Holmes, G.K.T. (2014). Morbidity and Mortality Associated with Celiac Disease. In: Rampertab, S., Mullin, G. (eds) Celiac Disease. Clinical Gastroenterology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8560-5_15

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