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Abdomen and Thoracic Imaging pp 253–278Cite as

Diffusion-Weighted Imaging of the Liver

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Abstract

Diffusion-weighted imaging (DWI) has been more frequently used in abdominal imaging after recent advances in technology including parallel imaging and EPI, particularly for assessment of liver. These advances in technology have reduced examination time and artifacts. DWI is quick and can be performed in a single breath-hold. It can be easily incorporated to the conventional MRI sequences. It is useful for the evaluation of focal and diffuse liver disease and has the potential for evaluation of tumor response to treatment.

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References

  1. Kwee TC, Takahara T, Niwa T, Ivancevic MK, Herigault G, Van Cauteren M, Luijten PR (2009) Influence of cardiac motion on diffusion-weighted magnetic resonance imaging of the liver. MAGMA 22(5):319–325

    Article  PubMed  CAS  Google Scholar 

  2. Guiu B, Cercueil JP (2011) Liver diffusion-weighted MR imaging: the tower of Babel? Eur Radiol 21(3):463–467

    Article  PubMed  Google Scholar 

  3. Gourtsoyianni S, Papanikolaou N, Yarmenitis S, Maris T, Karantanas A, Gourtsoyiannis N (2008) Respiratory gated diffusion-weighted imaging of the liver: value of apparent diffusion coefficient measurements in the differentiation between most commonly encountered benign and malignant focal liver lesions. Eur Radiol 18:486–492

    Article  PubMed  Google Scholar 

  4. Bruegel M, Holzapfel K, Gaa J et al (2008) Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echoplanar MR imaging technique. Eur Radiol 18:477–485

    Article  PubMed  Google Scholar 

  5. Kandpal H, Sharma R, Madhusudhan KS, Kapoor KS (2009) Respiratory-triggered versus breath-hold diffusion-weighted MRI of liver lesions: comparison of image quality and apparent diffusion coefficient values. AJR Am J Roentgenol 192:915–922

    Article  PubMed  Google Scholar 

  6. Feuerlein S, Pauls S, Juchems MS et al (2009) Pitfalls in abdominal diffusion weighted imaging: how predictive is restricted water diffusion for malignancy. AJR Am J Roentgenol 193:1070–1076

    Article  PubMed  Google Scholar 

  7. Goshima S, Kanematsu M, Kondo H et al (2008) Diffusion-weighted imaging of the liver: optimizing b value for the detection and characterization of benign and malignant hepatic lesions. J Magn Reson Imaging 28:691–697

    Article  PubMed  Google Scholar 

  8. Low RN, Gurney J (2007) Diffusion-weighted MRI (DWI) in the oncology patient: value of breathhold DWI compared to unenhanced and gadolinium-enhanced MRI. J Magn Reson Imaging 25:848–858

    Article  PubMed  Google Scholar 

  9. Lichy MP, Aschoff P, Plathow C et al (2007) Tumor detection by diffusion-weighted MRI and ADC mapping: initial clinical experiences in comparison to PETCT. Invest Radiol 42:605–613

    Article  PubMed  Google Scholar 

  10. Coenegrachts K, Matos C, Ter Beek L et al (2009) Focal liver lesion detection and characterization: comparison of non-contrast enhanced and SPIO-enhanced diffusion-weighted single-shot spin echo echo planar and turbo spin echo T2-weighted imaging. Eur J Radiol 72:432–439

    Article  PubMed  Google Scholar 

  11. Holzapfel K, Bruegel M, Eiber M et al (2010) Characterization of small (</=10mm) focal liver lesions: value of respiratory triggered echo-planar diffusion-weighted MR imaging. Eur J Radiol 76:89–95

    Article  PubMed  Google Scholar 

  12. Coenegrachts K, Delanote J, Ter Beek L et al (2007) Improved focal liver lesion detection: comparison of single-shot diffusion-weighted echoplanar and single-shot T2 weighted turbo spin echo techniques. Br J Radiol 80:524–531

    Article  PubMed  CAS  Google Scholar 

  13. Asbach P, Hein PA, Stemmer A et al (2008) Free-breathing echo-planar imaging based diffusion-weighted magnetic resonance imaging of the liver with prospective acquisition correction. J Comput Assist Tomogr 32:372–378

    Article  PubMed  Google Scholar 

  14. Sandrasegaran K, Akisik FM, Lin C, Tahir B, Rajan J, Aisen AM (2009) The value of diffusion-weighted imaging in characterizing focal liver masses. Acad Radiol 16:1208–1214

    Article  PubMed  Google Scholar 

  15. Demir OI, Obuz F, Sağol O, Dicle O (2007) Contribution of diffusion-weighted MRI to the differential diagnosis of hepatic masses. Diagn Interv Radiol 13:81–86

    PubMed  Google Scholar 

  16. Miller FH, Hammond N, Siddiqi AJ et al (2010) Utility of diffusion-weighted MRI in distinguishing benign and malignant hepatic lesions. J Magn Reson Imaging 32(1):138–147

    Article  PubMed  Google Scholar 

  17. Haradome H, Grazioli L, Morone M et al (2012) T2-weighted and diffusion-weighted MRI for discriminating benign from malignant focal liver lesions: diagnostic abilities of single versus combined interpretations. J Magn Reson Imaging 35(6):1388–1396

    Article  PubMed  Google Scholar 

  18. Yang DM, Jahng GH, Kim HC et al (2011) The detection and discrimination of malignant and benign focal hepatic lesions: T2 weighted vs diffusion-weighted MRI. Br J Radiol 84(1000):319–326

    Article  PubMed  CAS  Google Scholar 

  19. Inan N, Arslan A, Akansel G et al (2007) Diffusion-weighted imaging in the differential diagnosis of simple and hydatid cysts of the liver. AJR Am J Roentgenol 189(5):1031–1036

    Article  PubMed  Google Scholar 

  20. Fruehwald-Pallamar J, Bastati-Huber N, Fakhrai N et al (2012) Confident non-invasive diagnosis of pseudolesions of the liver using diffusion-weighted imaging at 3T MRI. Eur J Radiol 81(6):1353–1359

    Article  PubMed  Google Scholar 

  21. Piana G, Trinquart L, Meskine N, Barrau V, Beers BV, Vilgrain V (2011) New MR imaging criteria with a diffusion-weighted sequence for the diagnosis of hepatocellular carcinoma in chronic liver diseases. J Hepatol 55(1):126–132

    Article  PubMed  Google Scholar 

  22. Muhi A, Ichikawa T, Motosugi U et al (2009) High-b-value diffusion-weighted MR imaging of hepatocellular lesions: estimation of grade of malignancy of hepatocellular carcinoma. J Magn Reson Imaging 30(5):1005–1011

    Article  PubMed  Google Scholar 

  23. Ahn JH, Yu JS, Hwang SH, Chung JJ, Kim JH, Kim KW (2010) Nontumorous arterioportal shunts in the liver: CT and MRI findings considering mechanisms and fate. Eur Radiol 20(2):385–394

    Article  PubMed  Google Scholar 

  24. Lee MH, Kim SH, Park MJ, Park CK, Rhim H (2011) Gadoxetic acid-enhanced hepatobiliary phase MRI and high-b-value diffusion-weighted imaging to distinguish well-differentiated hepatocellular carcinomas from benign nodules in patients with chronic liver disease. AJR Am J Roentgenol 197(5):W868–W875

    Article  PubMed  Google Scholar 

  25. Xu PJ, Yan FH, Wang JH, Shan Y, Ji Y, Chen CZ (2010) Contribution of diffusion-weighted magnetic resonance imaging in the characterization of hepatocellular carcinomas and dysplastic nodules in cirrhotic liver. J Comput Assist Tomogr 34(4):506–512

    Article  PubMed  Google Scholar 

  26. Heo SH, Jeong YY, Shin SS et al (2010) Apparent diffusion coefficient value of diffusion-weighted imaging for hepatocellular carcinoma: correlation with the histologic differentiation and the expression of vascular endothelial growth factor. Korean J Radiol 11(3):295–303

    Article  PubMed  Google Scholar 

  27. Nasu K, Kuroki Y, Tsukamoto T, Nakajima H, Mori K, Minami M (2009) Diffusion-weighted imaging of surgically resected hepatocellular carcinoma: imaging characteristics and relationship among signal intensity, apparent diffusion coefficient, and histopathologic grade. AJR Am J Roentgenol 193(2):438–444

    Article  PubMed  Google Scholar 

  28. Le Moigne F, Durieux M, Bancel B et al (2012) Impact of diffusion-weighted MR imaging on the characterization of small hepatocellular carcinoma in the cirrhotic liver. Magn Reson Imaging 30(5):656–665

    Article  PubMed  Google Scholar 

  29. Xu PJ, Yan FH, Wang JH, Lin J, Ji Y (2009) Added value of breathhold diffusion-weighted MRI in detection of small hepatocellular carcinoma lesions compared with dynamic contrast-enhanced MRI alone using receiver operating characteristic curve analysis. J Magn Reson Imaging 29(2):341–349

    Article  PubMed  Google Scholar 

  30. Chung J, Yu JS, Kim DJ, Chung JJ, Kim JH, Kim KW (2011) Hypervascular hepatocellular carcinoma in the cirrhotic liver: diffusion-weighted imaging versus superparamagnetic iron oxide-enhanced MRI. Magn Reson Imaging 29(9):1235–1243

    Article  PubMed  Google Scholar 

  31. Kim YK, Kim CS, Han YM, Lee YH (2011 Jun) Detection of liver malignancy with gadoxeticacid-enhanced MRI: is addition of diffusion-weighted MRI beneficial? Clin Radiol 66(6):489–496

    Google Scholar 

  32. Koh DM, Brown G, Riddell AM et al (2008) Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination. Eur Radiol 18(5):903–910

    Article  PubMed  CAS  Google Scholar 

  33. Kim YK, Lee MW, Lee WJ, Kim SH, Rhim H, Lim JH, Choi D, Kim YS, Jang KM, Lee SJ, Lim HK (2012) Diagnostic accuracy and sensitivity of diffusion-weighted and of gadoxetic acid-enhanced 3-T MR imaging alone or in combination in the detection of small liver metastasis (≤ 1.5 cm in diameter). Invest Radiol 47(3):159–166

    PubMed  CAS  Google Scholar 

  34. Chung WS, Kim MJ, Chung YE et al (2011) Comparison of gadoxetic acid-enhanced dynamic imaging and diffusion-weighted imaging for the preoperative evaluation of colorectal liver metastases. J Magn Reson Imaging 34(2):345–353

    Article  PubMed  Google Scholar 

  35. Löwenthal D, Zeile M, Lim WY et al (2011) Detection and characterisation of focal liver lesions in colorectal carcinoma patients: comparison of diffusion-weighted and Gd-EOB-DTPA enhanced MR imaging. Eur Radiol 21(4):832–840

    Article  PubMed  Google Scholar 

  36. Shimada K, Isoda H, Hirokawa Y, Arizono S, Shibata T, Togashi K (2010) Comparison of gadolinium-EOB-DTPA-enhanced and diffusion-weighted liver MRI for detection of small hepatic metastases. Eur Radiol 20(11):2690–2698

    Article  PubMed  Google Scholar 

  37. Eiber M, Fingerle AA, Brügel M, Gaa J, Rummeny EJ, Holzapfel K (2012) Detection and classification of focal liver lesions in patients with colorectal cancer: retrospective comparison of diffusion-weighted MR imaging and multi-slice CT. Eur J Radiol 81(4):683–691

    Article  PubMed  Google Scholar 

  38. Muhi A, Ichikawa T, Motosugi U et al (2010) Diagnosis of colorectal hepatic metastases: contrast-enhanced ultrasonography versus contrast-enhanced computed tomography versus superparamagnetic iron oxide-enhanced magnetic resonance imaging with diffusion-weighted imaging. J Magn Reson Imaging 32(5):1132–1140

    Article  PubMed  Google Scholar 

  39. Koinuma M, Ohashi I, Hanafusa K, Shibuya H (2005) Apparent diffusion coefficient measurements with diffusion-weighted magnetic resonance imaging for evaluation of hepatic fibrosis. J Magn Reson Imaging 22:80–85

    Article  PubMed  Google Scholar 

  40. Lewin M, Poujol-Robert A, Boelle PY et al (2007) Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C. Hepatology 46:658–665

    Article  PubMed  CAS  Google Scholar 

  41. Taouli B, Tolia AJ, Losada M et al (2007) Diffusion-weighted MRI for quantification of liver fibrosis: preliminary experience. AJR Am J Roentgenol 189:799–806

    Article  PubMed  Google Scholar 

  42. Taouli B, Chouli M, Martin AJ, Qayyum A, Coakley FV, Vilgrain V (2008) Chronic hepatitis: role of diffusion-weighted imaging and diffusion tensor imaging for the diagnosis of liver fibrosis and inflammation. J Magn Reson Imaging 28:89–95

    Article  PubMed  Google Scholar 

  43. Girometti R, Furlan A, Bazzocchi M et al (2007) Diffusion-weighted MRI in evaluating liver fibrosis: a feasibility study in cirrhotic patients. Radiol Med 112:394–408

    Article  PubMed  CAS  Google Scholar 

  44. Girometti R, Furlan A, Esposito G et al (2008) Relevance of b-values in evaluating liver fibrosis: a study in healthy and cirrhotic subjects using two single-shot spin-echo echo-planar diffusion-weighted sequences. J Magn Reson Imaging 28:411–419

    Article  PubMed  Google Scholar 

  45. Sandrasegaran K, Akisik FM, Lin C et al (2009) Value of diffusion-weighted MRI for assessing liver fibrosis and cirrhosis. AJR Am J Roentgenol 193(6):1556–1560

    Article  PubMed  Google Scholar 

  46. Do RK, Chandarana H, Felker E et al (2010) Diagnosis of liver fibrosis and cirrhosis with diffusion-weighted imaging: value of normalized apparent diffusion coefficient using the spleen as reference organ. AJR Am J Roentgenol 195(3):671–676

    Article  PubMed  Google Scholar 

  47. Wang Y, Ganger DR, Levitsky J et al (2011) Assessment of chronic hepatitis and fibrosis: comparison of MR elastography and diffusion-weighted imaging. AJR Am J Roentgenol 196(3):553–561

    Article  PubMed  Google Scholar 

  48. Bonekamp S, Torbenson MS, Kamel IR (2011) Diffusion-weighted magnetic resonance imaging for the staging of liver fibrosis. J Clin Gastroenterol 45(10):885–892

    Article  PubMed  Google Scholar 

  49. Watanabe H, Kanematsu M, Goshima S et al (2011) Staging hepatic fibrosis: comparison of gadoxetate disodium-enhanced and diffusion-weighted MR imaging–preliminary observations. Radiology 259(1):142–150

    Article  PubMed  Google Scholar 

  50. Bakan AA, Inci E, Bakan S, Gokturk S, Cimilli T (2012) Utility of diffusion-weighted imaging in the evaluation of liver fibrosis. Eur Radiol 22(3):682–687

    Article  PubMed  Google Scholar 

  51. Kovač JD, Daković M, Stanisavljević D et al (2012) Diffusion-weighted MRI versus transient elastography in quantification of liver fibrosis in patients with chronic cholestatic liver diseases. Eur J Radiol 81(10):2500–2506

    Article  PubMed  Google Scholar 

  52. Luciani A, Vignaud A, Cavet M et al (2008) Liver cirrhosis: intravoxel incoherent motion MR imaging–pilot study. Radiology 249(3):891–899

    Article  PubMed  Google Scholar 

  53. Patel J, Sigmund EE, Rusinek H, Oei M, Babb JS, Taouli B (2010) Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience. J Magn Reson Imaging 31(3):589–600

    Article  PubMed  Google Scholar 

  54. Kamel IR, Bluemke DA, Ramsey D et al (2003) Role of diffusion-weighted imaging in estimating tumor necrosis after chemoembolization of hepatocellular carcinoma. AJR Am J Roentgenol 181(3):708–710

    Article  PubMed  Google Scholar 

  55. Mannelli L, Kim S, Hajdu CH, Babb JS, Clark TW, Taouli B (2009) Assessment of tumor necrosis of hepatocellular carcinoma after chemoembolization: diffusion-weighted and contrast-enhanced MRI with histopathologic correlation of the explanted liver. AJR Am J Roentgenol 193(4):1044–1052

    Article  PubMed  Google Scholar 

  56. Braren R, Altomonte J, Settles M et al (2011) Validation of preclinical multiparametric imaging for prediction of necrosis in hepatocellular carcinoma after embolization. J Hepatol 55(5):1034–1040

    Article  PubMed  Google Scholar 

  57. Schraml C, Schwenzer NF, Clasen S et al (2009) Navigator respiratory-triggered diffusion-weighted imaging in the follow-up after hepatic radiofrequency ablation-initial results. J Magn Reson Imaging 29(6):1308–1316

    Article  PubMed  Google Scholar 

  58. Kubota K, Yamanishi T, Itoh S et al (2010) Role of diffusion-weighted imaging in evaluating therapeutic efficacy after transcatheter arterial chemoembolization for hepatocellular carcinoma. Oncol Rep 24:727–732

    Article  PubMed  Google Scholar 

  59. Goshima S, Kanematsu M, Kondo H et al (2008) Evaluating local hepatocellular carcinoma recurrence post-transcatheter arterial chemoembolization: is diffusion-weighted MRI reliable as an indicator? J Magn Reson Imaging 27(4):834–839

    Article  PubMed  Google Scholar 

  60. Koh DM, Scurr E, Collins D et al (2007) Predicting response of colorectal hepatic metastasis: value of pretreatment apparent diffusion coefficients. AJR Am J Roentgenol 188(4):1001–1008

    Article  PubMed  Google Scholar 

  61. Cui Y, Zhang XP, Sun YS, Tang L, Shen L (2008) Apparent diffusion coefficient: potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases. Radiology 248(3):894–900

    Article  PubMed  Google Scholar 

  62. Anzidei M, Napoli A, Zaccagna F et al (2011) Liver metastases from colorectal cancer treated with conventional and antiangiogenetic chemotherapy: evaluation with liver computed tomography perfusion and magnetic resonance diffusion-weighted imaging. J Comput Assist Tomogr 35(6):690–696

    Article  PubMed  Google Scholar 

  63. Marugami N, Tanaka T, Kitano S et al (2009) Early detection of therapeutic response to hepatic arterial infusion chemotherapy of liver metastases from colorectal cancer using diffusion-weighted MR imaging. Cardiovasc Intervent Radiol 32(4):638–646

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiology, Muthanna University, Muthanna, Iraq

    Ali Muhi M.B.Ch.B., Ph.D.

  2. Department of Radiology, University of Yamanashi, Yamanshi, Japan

    Tomoaki Ichikawa M.D., Ph.D. & Utaroh Motosugi M.D., Ph.D.

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  1. Ali Muhi M.B.Ch.B., Ph.D.
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  2. Tomoaki Ichikawa M.D., Ph.D.
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  3. Utaroh Motosugi M.D., Ph.D.
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Correspondence to Ali Muhi M.B.Ch.B., Ph.D. .

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Editors and Affiliations

  1. Department of Bioengineering, University of Louisville, Louisville, Kentucky, USA

    Ayman S. El-Baz

  2. University of Cagliari, Cagliari, Italy

    Luca Saba

  3. Biomedical Technologies, Inc Idaho State University (Affiliated), Roseville, California, USA

    Jasjit Suri

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Muhi, A., Ichikawa, T., Motosugi, U. (2014). Diffusion-Weighted Imaging of the Liver. In: El-Baz, A., Saba, L., Suri, J. (eds) Abdomen and Thoracic Imaging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-8498-1_10

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