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MicroRNA SNPs in Cancer

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Abstract

MiRNAs could serve as the regulators of cell events, including such as differentiation, propagation, and apoptosis. MiRNAs could act as natural oncogenes or tumor suppressor genes. Whether a particular miRNA serves as either could almost be moot when the additional problems of SNPs enter the fray. A miRNA involved with SNPs (miR-SNPs) on any regulatory level, whether naturally cancer-inducing or not, could easily undergo an oncogenic transformation. This chapter reviews targets of miRNAs and the miRNAs themselves frequently containing SNPs reflecting different risks and markers of cancer with emphasis on familial groups and populations of shared heredity.

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  1. Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Yujing Li & Peng Jin

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  1. Yujing Li
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  1. Pediatrics and Molecular Microbiology &, University of Southern California Children's Hospital Los Angeles, Los Angeles, California, USA

    Muller Fabbri

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Li, Y., Jin, P. (2014). MicroRNA SNPs in Cancer. In: Fabbri, M. (eds) Non-coding RNAs and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8444-8_8

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