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Japanese Encephalitis and Dengue Virus Infection: Neurology and Neurobiology

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Abstract

Japanese encephalitis (JE) and Dengue virus infections are the most important arboviral infections. JE spreads by Culex mosquitoes and causes encephalomyelitis. JE virus has affinity for thalamus, striatum, midbrain and anterior horn cells of spinal cord; however it does not produce any systemic manifestation. JE results in death of 40 % of the patients and half of the survivors have neurological sequelae. There is no antiviral therapy for JE and the management is symptomatic; however it can be prevented by vaccination, Dengue occasionally produces neurological manifestations, which include encephalopathy, encephalitis, immune-mediated syndromes and muscle dysfunctions. The underlying pathophysiology is increased vascular permeability and coagulopathy. The neurological complications of dengue are more common in severe dengue infection. Management of dengue is also supportive and vaccines are under evaluation.

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Authors and Affiliations

  1. Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow, 226014, Uttar Pradesh, India

    Usha K. Misra & Jayantee Kalita

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  1. Usha K. Misra
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  2. Jayantee Kalita
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Correspondence to Usha K. Misra .

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Editors and Affiliations

  1. Department of Neurological and Movement Sciences, University of Verona, Verona, Verona, Italy

    Marina Bentivoglio

  2. Department of Neurology and Neurosurgery, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, Brazil

    Esper A. Cavalheiro

  3. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden

    Krister Kristensson

  4. Department of Physiology School of MedicineCollege of Health Science, University of Nairobi, Nairobi, Kenya

    Nilesh B. Patel

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Misra, U.K., Kalita, J. (2014). Japanese Encephalitis and Dengue Virus Infection: Neurology and Neurobiology. In: Bentivoglio, M., Cavalheiro, E., Kristensson, K., Patel, N. (eds) Neglected Tropical Diseases and Conditions of the Nervous System. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8100-3_15

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