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Biophysics of the Failing Heart pp 63–90Cite as

Biophysics of Membrane Currents in Heart Failure

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Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Heart failure (HF) is associated with an increased risk of sudden death and multiple ion channel changes. These ion channel changes that are thought to underlie the increased arrhythmic risk. Understanding these changes and their origins should allow for more effective therapeutic strategies free from the proarrhythmic effects limiting current ion channel-blocking drugs. This review summarizes some of the recent findings about ion channel biophysical changes during HF with an eye to the new therapeutic possibilities suggested by the data.

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Authors and Affiliations

  1. Section of Cardiology, University of Illinois at Chicago, Chicago, IL, USA

    Man Liu & Vikram Maddikunta Brahmanandam

  2. The Jesse Brown VA Medical Center, Chicago, IL, USA

    Man Liu

  3. Section of Cardiology, University of Illinois at Chicago/Jesse Brown VA Medical Center, 840 S. Wood Street, MC715, Chicago, IL, 60612, USA

    Samuel C. Dudley Jr.

Authors
  1. Man Liu
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  2. Vikram Maddikunta Brahmanandam
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  3. Samuel C. Dudley Jr.
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Correspondence to Samuel C. Dudley Jr. .

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Editors and Affiliations

  1. Dept. of Physiology & Biophysics, University of Illinois at Chicago, Chicago, USA

    R. John Solaro

  2. University of Arizona, Tucson, Arizona, USA

    Jil C. Tardiff

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Liu, M., Brahmanandam, V.M., Dudley, S.C. (2013). Biophysics of Membrane Currents in Heart Failure. In: Solaro, R., Tardiff, J. (eds) Biophysics of the Failing Heart. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7678-8_4

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