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Biophysics of the Failing Heart pp 225–247Cite as

Sarcomeres and the Biophysics of Heart Failure

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Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Changes in the function of the sarcomere play a significant role in the development of cardiac dysfunction underlying heart failure. These changes in sarcomeric properties are the result of either alterations in isoform expression, post-translational modification of the sarcomeric proteins, or gene mutations linked to hypertrophic or dilated cardiomyopathy. These alterations act to modulate the contractile state of the heart via direct effects on the biophysical properties of the cardiac sarcomere. Coupling a deeper understanding of the primary biophysical causes of changes in contractile function to a more complete understanding of the resultant pathogenic ventricular remodeling that occurs over time will allow for both significant advances in disease management and new points of therapeutic intervention.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA

    Jillian N. Simon Ph.D

  2. University of Arizona, 1656 East Mabel Street, MRB 312, MS# 245217, Tucson, AZ, 85724-5217, USA

    Jil C. Tardiff M.D., Ph.D.

  3. Department of Medicine, Section of Cardiology and Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois, Chicago, IL, USA

    Beata M. Wolska Ph.D

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  3. Beata M. Wolska Ph.D
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Correspondence to Beata M. Wolska Ph.D .

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  1. Dept. of Physiology & Biophysics, University of Illinois at Chicago, Chicago, USA

    R. John Solaro

  2. University of Arizona, Tucson, Arizona, USA

    Jil C. Tardiff

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Simon, J.N., Tardiff, J.C., Wolska, B.M. (2013). Sarcomeres and the Biophysics of Heart Failure. In: Solaro, R., Tardiff, J. (eds) Biophysics of the Failing Heart. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7678-8_11

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