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Unraveling the Local Influence of Tumor-Surrounding Adipose Tissue on Tumor Progression: Cellular and Molecular Actors Involved

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Adipose Tissue and Cancer

Abstract

Cells that compose the tumor stroma are associated, if not obligate, partners in tumor progression. Among the different cell types frequently found at close proximity of evolving tumors, little attention has been given to cells that compose the adipose tissue (AT) although a growing interest can be noted in recent years. AT is mainly composed of mature adipocytes that are able to secrete a large panel of bioactive molecules (adipokines) and adipose progenitors. Emerging studies clearly indicate that a bidirectional crosstalk is established between all cellular components of AT and cancer cells and that the tumor-surrounding AT contributes to inflammation, extracellular matrix remodeling as well as energy supply within the tumors. In this chapter, we present evidences showing how AT locally affects tumor progression in given types of tumors and how these results might be attractive to explain the link between obesity and the poor prognosis of some cancers. This will be preceded by the overall description of AT composition and function with special emphasis on the specificity of adipose depots, key aspects that need to be taken in account when paracrine effects of AT on tumor progression is considered.

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Acknowledgments

Studies performed in our laboratories were supported by the French National Cancer Institute (INCA PL 2006–035 and INCA PL 2010–214 to PV and CM), the “Ligue Régionale contre le Cancer” (Comité du Lot, de la Haute-Garonne et du Gers to CM), the Fondation de France (to PV and CM), the Association pour la Recherche sur les Tumeurs Prostatiques ARTP (to CM), and the University of Toulouse (AO CS 2009 to CM). We would like to thank Dr Max Lafontan for critical reading of the manuscript.

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Authors and Affiliations

  1. Université de Toulouse, UPS, 31077, Toulouse, France

    Catherine Muller, Laurence Nieto & Philippe Valet

  2. Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, 64182, 31077, Toulouse Cedex, France

    Catherine Muller & Laurence Nieto

  3. Institut National de la Santé et de la Recherche Médicale, INSERM U1048, 31432, Toulouse, France

    Philippe Valet

Authors
  1. Catherine Muller
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  2. Laurence Nieto
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  3. Philippe Valet
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Correspondence to Catherine Muller .

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Editors and Affiliations

  1. Science Center at Houston, Inst. Molecular Medicine, University of Texas, Pressler Street 1825, Houston, 77030, Texas, USA

    Mikhail G. Kolonin

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Muller, C., Nieto, L., Valet, P. (2013). Unraveling the Local Influence of Tumor-Surrounding Adipose Tissue on Tumor Progression: Cellular and Molecular Actors Involved. In: Kolonin, M. (eds) Adipose Tissue and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7660-3_7

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