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Multi-Modality Atherosclerosis Imaging and Diagnosis pp 95–106Cite as

Carotid Plaque Stress Analysis: Issues on Patient-Specific Modeling

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Abstract

Plaque stress analysis has been widely studied for understanding the mechanism of plaque initiation, development, and rupture. With development of computational power and medical imaging technique, plaque stress analysis has evolved from simplified 2D idealized mathematical model to much more complex model with 3D patient-specific structure. In this chapter, two issues regarding patient-specific plaque stress analysis have been studied: (1) patient-specific geometry and (2) patient-specific material properties. By using multispectral carotid MRI, 3D plaque geometries were reconstructed for one symptomatic patient and one asymptomatic patient with multicomponents, the followed plaque stress analysis showed plaque stress in the symptomatic patient had much higher value than that in the asymptomatic patient. Furthermore by analyzing carotid artery motion in one cardiac cycle, an anisotropic material model was fitted to the motion pattern of the selected carotid artery section. Then the fitted patient-specific material model was successfully applied to plaque stress analysis for the corresponding plaque sample. It is believed that plaque stress analysis with patient-specific modeling will be helpful in the identification of high-rupture risk patients.

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Acknowledgments

This project is supported by the British Heart Foundation (FS/06/048). The authors like to thank Dr ZY Li, Dr M Graves, M.D. JH Gillard from Department of Radiology, Cambridge University, for their contributions to all MR images, and collaborations in the project.

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Authors and Affiliations

  1. School of Mathematics and Statistics, University of Glasgow, Glasgow, UK

    Hao Gao

  2. Brunel Institute for Bioengineering, Brunel University, London, UK

    Quan Long

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  1. Hao Gao
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Correspondence to Hao Gao .

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Editors and Affiliations

  1. Department of Radiology, A.O.U Cagliari - Polo di Monserrato, Bivio per Sestu, Italy

    Luca Saba

  2. Instituto Superior Técnico Institute for Systems and Robotics, Lisboa, Portugal

    João Miguel Sanches

  3. Hospital de Santa Maria, Lisboa, Portugal

    Luís Mendes Pedro

  4. Stroke Research and Monitoring Division, AtheroPoint(TM) LLC, Roseville, California, USA

    Jasjit S. Suri

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Gao, H., Long, Q. (2014). Carotid Plaque Stress Analysis: Issues on Patient-Specific Modeling. In: Saba, L., Sanches, J., Pedro, L., Suri, J. (eds) Multi-Modality Atherosclerosis Imaging and Diagnosis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7425-8_8

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  • DOI: https://doi.org/10.1007/978-1-4614-7425-8_8

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  • Online ISBN: 978-1-4614-7425-8

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