Abstract
Anxiety during childhood and adolescence is a highly prevalent problem that contributes to long-term dysfunction in adulthood. This chapter highlights research on the neurobiology of pediatric anxiety disorders aimed at understanding how anxiety takes hold in the brain and the mechanisms that fuel its developmental course. We present an overview of anatomical and functional brain-based differences in children and adolescents with and without anxiety disorders. With regard to work focused on brain function in pediatric anxiety, we discuss four key psychological processes that are highly relevant to clinical characteristics in anxiety: attention orienting, threat learning, social–emotional information processing, and reward processing. We also review recent work that delineates connections between and within neural regions that appear to be distinctly modulated by anxiety both in response to specific tasks and while at rest. We close the chapter with a summary of emerging work on neurobiological response to treatments for anxiety in children and adolescents, followed by conclusions and future directions for this course of work.
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Acknowledgements
Support for this work was provided by the National Institute of Mental Health Intramural Research Program and National Institutes of Health Career Development Award K99/R900 MH080076 to A.E.G. The authors wish to thank Jennifer Buser and Sarah Ruiz for assistance with literature reviews and table and figure creation.
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Guyer, A.E., Masten, C.L., Pine, D.S. (2013). Neurobiology of Pediatric Anxiety Disorders. In: Vasa, R., Roy, A. (eds) Pediatric Anxiety Disorders. Current Clinical Psychiatry. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-6599-7_2
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