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Mouse Models of Pancreatic Ductal Adenocarcinoma

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Abstract

In the past several years, numerous genetically engineered mice have been used to model pancreatic cancer. These models differed based on the approach used (some use transgenes while others used homologous recombination), as well as on the oncogene or combination of oncogenes. The expression of an oncogenic form of Kras in the mouse pancreas at physiological levels has led to models that not only develop pancreatic ductal adenocarcinoma (PDA), but that mimic the progression of the human disease, including pre-carcinogenic stages, such as Pancreatic Intraepithelial Neoplasia (PanIN), and activation of specific signaling pathways. Thanks to genetically engineered mouse models we have started to discern the contribution of different signaling pathways to initiation and progression, and in some cases maintenance, of pancreatic cancers. We have also started dissecting the importance of the interactions between the tumor cells and their surrounding microenvironment. Notwithstanding the sophistication of the current models, further modification of the approaches used could be implemented, for example to develop mice with clonal tumors, such as seen in human patients. Moreover, applying genomic approaches to the study of the mouse models might shed light on their ability to recapitulate specific subsets of human tumors.

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Authors and Affiliations

  1. Department of Surgery, University of Michigan, Ann Arbor, MI, USA

    Filip Bednar & Marina Pasca di Magliano Ph.D.

  2. Department of Cell and Developmental Biology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5936, USA

    Marina Pasca di Magliano Ph.D.

  3. Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA

    Marina Pasca di Magliano Ph.D.

  4. Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA

    Marina Pasca di Magliano Ph.D.

Authors
  1. Filip Bednar
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  2. Marina Pasca di Magliano Ph.D.
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Corresponding author

Correspondence to Marina Pasca di Magliano Ph.D. .

Editor information

Editors and Affiliations

  1. MED CTR ROOM 2922D, TC, University of Michigan, E Medical CTR Drive 1500, Ann Arbor, 48109-0999, Michigan, USA

    Diane M. Simeone

  2. CRB 2/STE 345, Johns Hopkins University, Orleans Street 1550, Baltimore, 21231, Maryland, USA

    Anirban Maitra

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© 2013 Springer Science+Business Media, LLC

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Bednar, F., di Magliano, M.P. (2013). Mouse Models of Pancreatic Ductal Adenocarcinoma. In: Simeone, D., Maitra, A. (eds) Molecular Genetics of Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6549-2_7

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