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Merlin and Angiomotin in Hippo-Yap Signaling

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Abstract

Merlin, encoded by the NF2 tumor-suppressive gene, has been ­established through genetic studies in both Drosophila and mice as an important upstream regulator of the Hippo-Yap pathway. Recently, biochemical studies have identified Angiomotin and Angiomotin-like proteins as major interacting partners for both Merlin and Yap. The exact mechanisms of how Merlin and Angiomotin regulate Hippo signaling remain undetermined. In this chapter, we will summarize past findings and discuss controversies and remaining questions regarding the roles of Merlin and Angiomotin in Hippo signaling and tumorigenesis.

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Authors and Affiliations

  1. Molecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA

    Chunling Yi

  2. Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL, USA

    Joseph Kissil

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  1. Chunling Yi
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  2. Joseph Kissil
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Correspondence to Chunling Yi or Joseph Kissil .

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Editors and Affiliations

  1. , Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel

    Moshe Oren

  2. , Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel

    Yael Aylon

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Yi, C., Kissil, J. (2013). Merlin and Angiomotin in Hippo-Yap Signaling. In: Oren, M., Aylon, Y. (eds) The Hippo Signaling Pathway and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6220-0_2

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